Ok so I had no luck with disulfiram. Was on it 5 days - did nothing but give me a peripheral neuropathy which i have recovered from in full. Don’t think its demethylating effect was strong enough and the literature agrees with me.
So at the moment that only really leaves procaine, and azacitadine.
The side effects of the latter are:
Azacitidine appears to be well tolerated, with the most com- mon grade 3 or 4 events being peripheral blood cytopenias.6 Injection site complications are the most common treatment- related non-hematological complications in subcutaneous azacitidine dosing, followed by nausea and vomiting. Although sometimes severe, myelosuppression is usually tran- sient, with most patients recovering before their next treatment or usually managed with dosing delays (23%–29%).
The highest proportion of adverse events occurs during the first two cycles, and the drug’s tolerability improves sub- sequently. The infection rates were not statistically different when comparing with basic support (RR = 1.00 [95% CI: 0.81, 1.22], P = 1.00]. The administration-related events such as nausea and vomiting occurred typically in the first week of drug delivery, resolved with antiemetics during the studies. The majority of injection site complications are typically mild erythema, and most improve after the application of warm or cold compresses to the affected area for a couple of hours.
IF DNA methylation is the issue this is at the moment probably our only hope.
