Info on GABA levels and relationship to depression:
So what r u saying most people with low Gaba are mentally ill
It’s just interesting to note that based on this study, they conclude that low GABA levels may pre-dispose someone to depressive or other mood disorders.
Abstract:
y-Aminobutyric acid b, an inhibitory neurotransminer
that serves about one-third of brain neurons, is
involved in the development of depression and in the
treatment of depression and mania with pharmacological
therapy. [/b]
Brain activity of GABA may be conveniently measured
in plasma, and changes in plasma concentrations
of GABA reflect brain GABA activity.
Plasma concentrations
of GABA are signfficantly lower than control values
in about one-third of patients with major depressive disorder;
concentrations are also low in patients with mania
and in bipolar patients who are depressed.
These low
concentrations of GABA appear to persist after recovery
from depression and are not increased by treatments that
improve depressive symptoms. Follow-up studies suggest
that GABA concentrations remain relatively constant
over at least 4 years. Additionally, preliminary data suggest
that low plasma GABA is a familial marker of mood
disorders in a subset of patients.
Despite the difficultyof
demonstrating that a particular biochemical measure is a
true genetic trait marker for vulnerability for development
of an illness, the accumulated data suggest that low
plasma GABA may represent a biological marker of vulnerability
for development of various mood disorders.
Mew
Do you know any supplements or anything that can raise the Gaba levels
funny you should say this and we’re here talking about it. GABA is basically the overall neurosteroid that allows for the entire brain system to function properly, i.e. allo-pregnenolone etc produces it. I wouldnt say im mentally ill as much as emotionally numb to everything, and physically exhausted. I’ve been having muscle twitches from hell too recently so it’s all very interesting. Any drug that somehow raises GABA levels which they are trying to come out with would be extremely beneficial but the problem with that is anything that directly affects GABA alcohol, marijuana, and GHB etc would send the user into a drunken/high sort of state. Anyway, they’re putting me on xyrem so I should finally get some needed deep sleep but the effect on GABA is far less potent than real ghb.
Alcohol also? That could explain why I had 2 days of recovery to pre-fin state after I drunk a lot at the party 
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Ithappens what is xyrem, and do you have any relief with it.
Xyrem is sodium oxybate (the salt crystals of GHB). It basically is a medication used for narcolepsy and cataplexy. It’s suppose to work is a similar manner to that of real ghb, sending the user into a deep stage 3 and 4 sleep for a period of time etc. I have not taken it yet I just recently had it prescribed, and will have to wait to be approved for it, and get it as it is a highly controlled thing here. Problem is real pure GHB would be far more powerful and work a lot better while Xyrem is so weak it just sort of gets you by. Also i’m not sure how effective xyrem is on increasing GABA compared to real GHB.
Is ghb illegal and the the other one and can you become addicted to it.
yes here in the US it is ILLEGAL unfortunately and yes when abused and taken multiple times throughout the day GHB can become addictive. However, and I do stress when taking daily small amounts at night just for sleep there seems to be some very beneficial properties. There is no evidence to suggest either way that when taken properly and not abused GHB is or isn’t addictive, as many users who have taken it in controlled doses over the years claim it isn’t. As with xyrem there is little chance at all for addiction just based on my own personal opinion and observations. It is far less stronger than real GHB and many from every doctor I talked to and user etc when taken at the prescribed nightly amount there is little to chance of addiction. However, the problem remains Xyrem probably won’t be strong enough to tickle this situation in terms of deep sleep and GH release, real GHB is most likely a far better option, in my opinion.
ithappens: hopefully that helps you. If it does, is it a medication that has to be taken for life? You are lucky you live in the US, here in Scandinavia I will probably have difficulties getting even clomid before trying TRT.
Onni I honestly hope it helps too. I realize that you may have a hard time getting on xyrem as i think i read somewhere it is still in the process of being released throughout europe. However, in europe GHB/GBL is still very much bought and sold in the drug trade and I have no doubt that if you looked hard enough you could find some or the ingredients to make your own. Here in the US though the stuff has literally been removed from the streets as it is a scheduled 1 substance, you get caught with this and you’re probably gonna go to jail. I asked a few of my shadier friends over the past year about it, and basically and I quote from one of them “you have a better chance of finding heroin”. Anyway, as far as taking it for life I dunno. Xyrem is far less powerful than true GHB so it may not even work, but the bottom line is i need it to help with deep sleep so hopefully i can recover and lead a somewhat normal life. I just hope it at least works and i can take it from there.
Neuroactive Steroids in Schizophrenia
ww1.cpa-apc.org:8080/Publication … bbo-RP.pdf
For those experiencing “dementia” or feelings of mania while on Finasteride, this article may provide some insight.
Looks like our old friends, the neuroactive steroids Allopregnanlone (3a, 5a-THP), Tetrahydrodeoxycorticosterone (3a, 5a-THDOC) and GABA-A are interfered with when it comes to schizophrenia. There is a diagram in this paper illustrating where 5AR comes into play.
Of course, Finasteride blocks Allopregnanolone and THDOC production thanks to blockade of 5AR-reduction of these metabolites, so they can no longer act properly on GABA-A while the drug is taken.
As well, the authors mention antipsychotic drugs which can be used to boost Allopregnanlone and THDOC: olanzapine, and clozapine. However, these are only mentioned in passing – taking such medications may be extremely dangerous, as mechanisms of action are not fully known and overdose can possibly lead to death or other problems.
More reasons as to why Finasteride can induce anxiety-like symptoms, ie due to withdrawal/blockade of Allopregnanolone.
Is Alchohol the solution for the anxiety/Brain fog ?
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funny you say that… everytime I drink, the next day im always able to think clear and feel good.
No. I always felt better the day after drinking, but it would not last and ultimately I would end up feeling worse. It is a nice respite once in awhile.
Agreed as well. My speech actually becomes close to perfect with alcohol (ethanol), at least while it’s in me…
I have sometimes when I drink the alcohol doesnt get me drunk like it used to. I can get drunk sometimes and other times its like im fine
this is exactly what i also experienced