PSSD Recovery from Urecholine (bethanechol)

General Discussion
#1

http://www.pssdforum.com/viewtopic.php?f=20&t=2586

vkg sent me this, and I hadn’t seen it discussed here. There are two people that have reported using this so far on this thread, its 19 pages so I copied them below…

Hello !!! I’ve been reading this forum for 3 years but I have never made an account here. I will write using a translator and I will try to summarize everything. I received PSSD from escitalopram 3 years ago. I took him for 2 months and interrupted because of sexual side effects. After a few months, nothing came back. The psychiatrist assigned me a trazodone that did nothing. Wellbutrin was later, who did not do it (300mg). I went to a good Urologist, who was assigned to me by Urecholine. After this medicine I did not feel anything at first, only after three weeks suddenly all sexual functions came back. I had problems with the stomach and intestines after the SSRIs. I did not have an appetite. This drug helped me with stomach and intestinal problems and restored sexual function. A few days before I returned to sexual function, I wanted to stop the treatment because I felt a strangely spreading heat on my stomach and around the bladder. I took a dose of 4x 25mg. I thought I would never regain sexual function. I’m fucking happy !!! I have the impression that I am more emotional than before taking an SSRI. Music makes me happy again, I have shivers.

So its a week for me now today.
I took the drug 4x 25mg a day.
My symptoms in the first place we’re:
-genital anesthesia ( felt like my dick is not a part of my body anymore )

  • numb skin everywhere especially at the finger pits
  • very less pleasure while masturbating
  • hard to achieve orgasm - but possible
  • pleasurless orgasm
  • delayed orgasm
  • low libido
  • no nocturnal erections / morning wood ( at least very rare )
  • couldn’t get erection without physically stimulation
  • erection strength was slightly worse but okay
  • was only anhedonia the first 2 month, then it was gone from alone - tried suplements but wouldn’t say the helped me.
    At like the secound day I could feel that my skin weren’t as numb as before. I thougt it will be placebo maybe, so I didn’t gave it much attention. But it got better than I could ever expect.

As I said in on day 7 now.

My skin numbness and genital anesthesia is completely gone. I can feel my dick now as a part of my body again.
Also i had nocturnal erections and morning wood the last 2 days.
My orgasm is still a bit pleasurless and delayed, but very much better than before. My pleasure while masturbating is also better to a good degree - but not perfect.
I watched porn yesterday and got hard without touching.

I could say i improved in every symptom especially in anesthesia.
I know its only 7 days, but i swear everything is totaly true. I will answer all questions.
My mood is very good today too - not sure if its because my depression is lifting or because urecholine is raising oxytocin - the love hormone.

3 Likes
#2

My niece is a psychiatrist, I’ll consult her about this…

#3

Woah, just read through that whole thread and it seems like 3 separate users are seeing quick and profound recoveries from complete PSSD/PFS symptoms (numbness, ED, anhedonia, nighttime erections, libido)?

I don’t want to succumb to the next ‘miracle drug’ that leads to nowhere, but there actually might be something to this. Seeing how the mechanism of this drug functions within the acetylcholine receptors within the gastrointestinal tract (correlating with the common theory how PFS is all gut related) and muscarinic receptors of the parasympathetic nervous system, this could have some real cogency for us. Going to keep researching.

Studies showing efficacy:

  1. Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by Tricyclic antidepressants and mazindol: case report.
    https://www.ncbi.nlm.nih.gov/pubmed/3957884

  2. Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants.
    Gross MD.
    https://www.ncbi.nlm.nih.gov/pubmed/7114318

Anyone out there have any experience?

#4

I’ve had a list I’ve accumulated of things I’d be willing to try if things don’t get better… this was already high in the list from what I found on it. It looks like it could really help.

Any suggestions on where to get it? It seems steroids are easier to get, lol

#5

Where did the two people from the forum get it from?

1 Like
#6

That’s crazy. Wonder if it works on 5ar inhibitor people too. This is on my list to try.

1 Like
#7

He never took the medecine, it’s a fake statement. You can reach page 19 and read his message.

#8

Yep, how unbelievably sick and ridiculous to lie about something like that.

The thing is, two other members have reported having more than positive effects, one stating they’re having close to a complete recovery as seen below (already posted by OP):

"So its a week for me now today.
I took the drug 4x 25mg a day.
My symptoms in the first place we’re:
-genital anesthesia ( felt like my dick is not a part of my body anymore )

* numb skin everywhere especially at the finger pits
* very less pleasure while masturbating
* hard to achieve orgasm - but possible
* pleasurless orgasm
* delayed orgasm
* low libido
* no nocturnal erections / morning wood ( at least very rare )
* couldn’t get erection without physically stimulation

* erection strength was slightly worse but okay
* was only anhedonia the first 2 month, then it was gone from alone - tried suplements but wouldn’t say the helped me.
At like the secound day I could feel that my skin weren’t as numb as before. I thougt it will be placebo maybe, so I didn’t gave it much attention. But it got better than I could ever expect.

As I said in on day 7 now.

My skin numbness and genital anesthesia is completely gone. I can feel my dick now as a part of my body again.
Also i had nocturnal erections and morning wood the last 2 days.
My orgasm is still a bit pleasurless and delayed, but very much better than before. My pleasure while masturbating is also better to a good degree - but not perfect.
I watched porn yesterday and got hard without touching.

I could say i improved in every symptom especially in anesthesia.
I know its only 7 days, but i swear everything is totaly true. I will answer all questions.
My mood is very good today too - not sure if its because my depression is lifting or because urecholine is raising oxytocin - the love hormone."

I’m going to wait for that users response (Zolofthaters) to this before completely writing this off. This also coupled with the few studies relating this with curing ED makes me feel like there is still a glimmer of hope here. I also experience incredibly dry mouth and eyes since quitting FIN, and this seems to address exactly that which could lead to something.

#9

Wow Curepssd is a cock juggling asshole.

“Sorry to all of you
I wanted someone to try this medicine because no one would ever take it
I never took this medicine
And I saw research on the internet about the recovery of the patient after tricyclic drugs. For this drug is used as an off label in GERD and we have disorders in the stomach and intestines
Sorry guys, but it’s worth trying this medicine.”

He might’ve even invented the other profile with recovery on the same drug so we should all be extremely skeptical until otherwise.

#10

@Jaime Starting to think Zolofthaters might be CuredPSSD… Unbelievable. Still holding out the slightest hope.

1 Like
#11

I think they are the same person.

1)Zolofthater’s account was created 2 months before CuredPSSD made that bullshit topic.
2) Both of the users have broken English and it looks like they’re using a translator. They use the same voice when writing.
3) Zolofthater thanked CuredPSSD for “coming back and reporting.”
4) Zolofthater somehow got a script for this stuff from his urologist by just saying he had a dry mouth.

I could be looking at this too deeply and with a pessimistic lens on, but for safety’s sake, we should all be skeptical.

2 Likes
#12

Indeed. Geez.

#13

You make solid points. Damn, really wanted this one to be real.

#14

There are studies that show urecholine helped reverse ED in patients suffering from ED from tricyclic antidepressants so it’s not like he made the entire thing up. Enough published reports that I’d consider taking it still.

But still, real shitty of him to do that.

#15

Doesn’t look like anyone has tried it on here. Would y’all consider it worth it to give it a try?

#16

I’m furious at that idiot, but do consider it worth a try since it’s relatively low cost and low side effect. I have a couple other things to evaluate first, but otherwise I’d probably give it a shot.

#17

So, I’m not writing this off entirely just yet. It appears some users are still having benefits from Bethanechol - Zolofthater is reporting 0% - 95% improvement, although we’re still a bit skeptical about him. I’m wondering what others think about the drug mechanism and the studies here. This still seems like something that is worth looking at.

#18

Yeah, I believe there is still value to this drug. If these drugs work or help PFS/PSSD people, I wonder if that implies a problem with Acetylcholine (ACh) transmission? ACh is used in almost every nervous circuit and is partially responsible for libido and erections. It’s also involved in sweating (many of us sweat less including me), learning and memory (memory loss is frequently reported as a symptom we share), and is found at every neuromuscular junction.

Maybe in the autonomic nervous system, our ACh transmission is impaired?

ACh modulation is not a route we’ve talked a lot about, but worth investigating in my novice opinion.

#19

@Jaime Exactly, this is definitely a new route that hasn’t really been discussed before yet. I’m just praying that we can get some more positive feedback from real users of the drug. It appears very low-risk, I may want to give it a try. Any other thoughts or users out there?

1 Like
#20

If you do decide to try ACh agonists, really inform yourself on the side effects and drug interactions. Too much ACh is bad news, and can result in a cholinergic crisis. Just trying to spread harm prevention is all.

I used to have hyperhidrosis, which is excessive sweating (now I don’t sweat much). They gave me a drug to block acetylcholine. This was way before I got sick, but I remember feeling like a complete zombie - sort of like during the initial crash. I know that’s very low anecdotal evidence, but observations can be invaluable.

1 Like