But how does the prostatitis come so quick? People already feel side effects on the first few days on the drug. Does normal microflora become pathogenic?
I have a question, Iām really scared about thisā¦ Not all the time, but some times I notice that when I was (not anymore) able to have an erection, the muscle between anus and testicles which I believ is the pelvic floor, would swell a lot. Is it a symptom?
Also, some times after ejaculating (only if masturbating) I would feel pain a lot in the prostate.
1 day I felt so much pain that I went to the doctor and he did the Index finger test, and said it was normal.
Is this pain, also a symptomā?
Thanks!
Yes it is exact
Iām already taking 4th antibiotics for CPPS now. I really hope it will work. Ofloxacin, ciprofloxacin, ampicillin/sulbactam didnāt work. Now trying TMP/SMX and for a longer period. What I want to try after that is clarithromycin and doxycyclin. Thereās still some hope left.
Has anyone ever cured this situation with antibiotics?
I have a question for people and if they canāt answer an experiment for:
Does drinking green tea help or worsen prostatic symptoms? This means pain, needing to go to the toilet more etcā¦
If you havenāt tried it could you try it for a day and let me know.
As you might know green tea has anti androgenic properties and blunts the androgen receptor. It also has epigenetic effects.
it also:
endo.endojournals.org/content/141/3/980.short
We found that EGCG, but not related catechins, significantly reduced food intake; body weight; blood levels of testosterone, estradiol, leptin, insulin, insulin-like growth factor I, LH, glucose, cholesterol, and triglyceride; as well as growth of the prostate, uterus, and ovary.
also wish to put forward this:
sciencedirect.com/science/article/pii/S0022534701660567
Transurethral microwavethermotherapy appears to be an effective, safe and durable treatment for some patients with nonbacterial prostatitis unresponsive to traditional therapy.
I think this is certainly an option for us with persistent prostate issues.
Not sure if itās mentioned, but, I would recommend uroxatralā¦ an alpha blocker. Itās helped my pelvis feel less tense.
Iām using Xatral. Itās helping me pee.
I have been experimenting with ketotifen - an antihistamine. Most antihistamines are contraindicated in prostatitis issues due to the relaxation they induce of the bladder walls. This one isnāt for some reason.
Since starting it my pain has substantially reduced and changed location. It used to be more perineal but now is more near the base of my coccyx.
That being said my sexual function has actually worsened on it. Ketotifen is not anti androgenic like some antihistamines. I have been researching and this will be part of my writing when finished that inflammation can actually upregulate androgen receptors. So paradoxically it might worsen things. However, i had a break of it for a couple of days and I had probably the strongest morning erection i have had for a while. Pain did not come back but it was only a few days then went back on it. As antihistamines reduce inflammatory cytokines i believe this is why it has had effect.
Now androgens seem to promote inflammation and reduce it in different areas of the body so I need to clarify this but it seems in the prostate at least testosterone and androgens are anti inflammatory and estrogen is inflammatory. In the skin for example androgens are pro-inflammatory - think acne.
Inflammation influences estrogen metabolism.
ncbi.nlm.nih.gov/pubmed/22145816
Oestrogen administration dramatically increased the inflammatory markers TNF-Ī± and PGE2.
Quotes from full article:
TNF-Ī±per se has been used to show the effect of inflammation on oestrogen metabolism and signalling in isolated endometrial cells [23]. Further, PGE2 has been shown to significantly increase endogenous oestrogen biosynthesis in prostate stromal cells as well as in breast fibroblast cells secondary to aromatase enzyme overexpression [24]. Two days after induction of inflammation, the proliferation marker, cyclin-D1 was overexpressed in inflamed prostate tissues and further aggravated by oestrogen administration. As in the present study, oestrogen has been shown to increase rat prostatic proliferation by modulating cell cycle transition proteins such as cyclin-D1, which remained highly expressed for 5 days [30]. Thus, the observed enhancement of prostatic proliferation and cyclin-D1 overexpression might be attributed to auto-augmentation interaction between inflammation and oestrogenic activity.
Lastly oestrogenās effects on the prostate are NOT thought to be receptor related
Given that oestrogen metabolite-induced effects are believed to be receptor-independent [23], the key element in aggravating prostatic inflammation would be catechol oestrogen metabolites rather than oestrogen per se.
sciencedirect.com/science/article/pii/S0022534705615042
More quotes from previous article i mentioned:
Some mechanisms of the estrogen effect are an increase in mRNA transcripts of TNF-Ī±, IL-1Ī², IL-6, MIP-2 and inducible nitric oxide synthase. 46 Studies have also shown that co-administration of testosterone with estradiol prevented estrogen induced prostatitis, while dihydrotestosterone (DHT) was less effective. 45 This suggests that testosterone must exert an independent role on the prostate aside from conversion to DHT.
Steroid hormones may be also be affected locally by the inflammation. In models of autoimmunity there is evidence of chemotactic cytokines such as TNF-Ī± and IFN-Ī³ altering the surface of endothelial cells, favoring mononuclear cell homing and infiltration, thus, leading to decreased steroid hormone production. 47 In the rat model of autoimmune prostatitis inflammation impairs 5Ī± reductase activity and lowers the intraprostatic levels of DHT relative to testosterone. 48 Given the effects of testosterone on prostate inflammation, this may be a mechanism to limit prostatic inflammation. This observation may be the basis of the possible beneficial clinical effect seen with the use of finasteride for CPPS, which inhibits the conversion of testosterone to DHT and may increase local testosterone levels. 49 Recent findings on the genetics of patients with CPPS bolster the theory that there may be an underlying problem with androgens in prostatitis.
To our knowledge whether there is a defect in the interaction between androgen receptor and membranes such as the nuclear envelope in men with CP/CPPS remains to be determined. Overall these findings lead to the possibility that if testosterone protects against inflammation, as seen in animal models, androgen insensitivity may lead to prostatic inflammation.
Now all of this most likely stems from a degree of androgen insensitivity which is what awor and co are researching into. However, at this point it is unknown whether helping the prostate issues will have any effect on the epigenetics. Therefore it seems wise to concentrate on dealing with both simultaneously.
Uroxatral still working great. Im sitting in a coffee shop typing thisā¦ and can get an erection on its way looking at a random chick.
Showered this morning and water sprayed.on.the prostate gave me an erectionā¦first time in forever.
Semen is pure white, too. I think Iām turning a corner with this shit, finally.
Thatās fantastic, man. I hope you can maintain this.
I think some of the tall foreheads around here should drill down and examine why this medication can bring about such a dramatic improvement.
Stayed 2 months on Xatral, but I had zero improvements.
BTW I have no ED, but a dramatic low flow and frequent urination.
I have taken Xatral for like 4 months now, but thereās no improvement in the look of my sperm: itās still transparent. There have been improvements in my fertility parameters though. Iām quitting it soon.
Hmmm, interesting. Were you guys taking it for urinary flow issues or for off-label uses (like pfs)?
For urinary flow.
I have a 10 ml/s peak flow and frequent urination 
Changing alfuzosin for doxazosin and starting clindamycin, because staphlycocci were found in my semen. Very good news! I will finally be cured. After tha Zn and Se. Oh, and Iām also taking fish oil capsules for omega-3 fatty acids. They probably are relieving the inflammation as thereās no sign of it left in the semen.
Not sure if i mentioned this beforeā¦ but, my semen has also changed from a slightly yellowish color, to totally white. There is a healthy amount and it comes out with a pretty good force. More positive signs i hope.
so guys in your opinion what is the best alfa blocker?
a1blockers like alfuzosin tamsulozin or a2a2 like phentolamin ?
And most important: are alpha blockers curative or only symptomatic drugs?
Hope that worked for you. I took clindamycin and it totally ruined my āgood bacteriaā. Probably too late for you, but for anyone else make sure you eat lots of yogurt and take probiotics when taking clindamycin. There are tons of horror stories on the internet about it.