Hey guys – I have intentionally boycotted the forum for a long time – I could not deal with the negativity and in-fighting any longer. It’s done me a lot of good to go away indefinitely and work on other parts of my life so that when the cure arrives, I’m ready to go. But I have something that I hope you’ll give some thoughtful consideration – something I thought compelling enough to break my fast from the forum.
I have (borrowed and re-visited) the idea that finasteride is STILL in our systems and here’s why:
Venceremos has been suffering from fluoroquinolone antibiotic-related tendon damage since his prostate treatment of over one and a half years ago. He recently relayed that he had HLPC testing done which confirmed that he still had levaquin circulating in his blood, after only having taken TWO 500mg doses of it. I repeat: ONE AND A HALF YEARS AGO. TWO DOSES. STILL IN HIS BLOOD. Interestingly enough, he took fifteen 1000mg ciproflocaxin pills, yet has a lower concentration of that in his system. He was not able to test for levels of the other antibiotics he took.
If a class of drugs which is known to cause serious, lasting, debilitating side effects like fluoroquinolone antibiotics is confirmed to be in sufferers’ blood stream (many confirmed cases), more than one and a half years after consumption in this particular case – how can we not take seriously the possibility that finasteride, a drug known to inhibit its own metabolism via inhibition of the CYP3A4 liver enzyme (ncbi.nlm.nih.gov/pmc/articles/PMC2740403/) - which ALSO is known to cause serious, lasting, debilitating side effects — is still in our systems?
I’ll summarize that last thought again:
ncbi.nlm.nih.gov/pmc/articles/PMC2740403/
“Importantly, finasteride itself is metabolized by CYP3A4, suggesting that high dose finasteride might prevent its own metabolism”
Separately, we know from Merck’s own studies that there is no difference between high and low dose finasteride.
[Size=4]
The theory of finasteride STILL being present in our systems would explain why:[/size]
-some people are hit after just a few doses, some after several months, some after several years (we all have different constitutions, different metabolisms, different enzymes, different genetic makeups, different detoxification capability, and so forth)
-some people experience fleeting, temporary recoveries via seemingly disparate means: milk thistle, fasting, heavy metal detox, juicing. (toxins/pharmaceuticals simply get recirculated. *See the attached Scientific Study on Toxicology and the excerpt at the end of this post on enterohepatic recirculation)
- some long-term TRT users (golf, enden, one other 2 year Dr. Crisler patient who’s name escapes me) are able to stimulate 5AR/overcome any suppression or toxicity from still-present fin and have working, functional sexual recoveries
[b]-Nystatin (which I have received confirmation up-regulates 5AR) helps so many who try it - and does not create resistance to (gasp! lol) candida with multiple starts/stops. But causes regression once stopped (too soon?)
-IHP – who both detoxed (bentonite clay, chinese herb flushes, zeolite, bentonite clay, IR sauna) AND took copious amounts of Nystatin – would seem to have both purged his system of fin AND up-regulated 5AR
-IHP completely recovered sexually, but not mentally (still some brain fog, although it’s slowly improving he just reported to me). Why? Perhaps because he had started with fin, but then moved on to dutasteride which inhibits 5AR1 as well (among other areas, more present in the brain), and “only” up-regulated 5AR2 via Nystatin? Or didn’t clear enough from his system?
-those that did heavy metal cleanses temporarily felt better (elimination organs backed up w/ metals were cleared allowing toxins like fin to shuttle around)
-some of the anecdotal (but hard to verify) recoveries using GHB/Xyrem coupled with Nystatin occurred
-PFS patients suffer so many comorbid conditions including immune dysfunction, infections, adrenal issues, thyroid issues, etc. — chronic 5AR suppression would have a cascade effect on the immune system, skin, digestion and beyond
-personally, I felt my best, almost like I was turning a corner (was able to get half-aroused again and “only” need one 20mg cialis dose to have sex) while combining the following therapies: routine H202 IV treatments (along with glutathione – liver pathway detoxifier), nystatin, juicing, colonics. When I stopped/slowed these things (and when I tested masturbation more), things regressed until I hit rock bottom again.[/b]
Again, this would explain one of the biggest puzzles – how can ANY substance act so quickly/permanently in some, and take so long to take others down – and exact such persistent side effects? And how can so many disparate means of treatment (from TRT to Nystatin to Juicing to Milk Thistle) be connected?
[Size=4]In my view, there is enough here to warrant/demand that the PFS Foundation devote serious attention to ruling out this possibility. Currently, there is just one institution that has mapped the finasteride molecule – but if an organized bunch presented the PFS phenomenon to them, with all the published science and media accounts, we COULD persuade and finance sending multiple blood samples for testing. This should be done immediately.[/size]
Likewise, practically speaking, it behooves us to look into serious, scientifically-backed means of expelling pharmaceuticals. At the top of my short list (longer outline of ideas in the attached Toxicology Study) are: plasmapheresis, hemodialysis, IR Sauna, Bile Acid Sequestrants, Zeolite, etc. We’re talking liver, kidneys, colon/bile acids, sweat, maybe lymphatic drainage??
[Size=4]One thing I need help on is learning if finasteride is protein bound (suggesting plasmapheresis) vs. having a low molecular weight (suggesting hemodialysis).[/size]
This is just a theory – but one that I feel deserves to be looked at seriously by individuals talking to their practitioners, by individuals exploring potential treatments, and by the research community at large. This is too big, too simple and obvious to rule out. Even respected endocrinologists I’ve spoken with admit that it IS a possibility. Many drugs, many compounds are known to stay in humans for a LONG time after cessation. Finasteride is a prime suspect for this phenomenon if you ask me. READ THE DAMN PAPER I LINKED TO AT THE BOTTOM!
I hope someone finds this interesting and useful and inspiring. I have not even bothered looking around to see if Venceremos has shared the details of his story yet or if I’ve posted something redundant, but here it is, anyway. Hope this is our year!
*From attached Toxicology Study (please take the time to download and read this important paper):
[i]Some bile-excreted xenobiotics that are surface active, or which possess structural or behavioral prop- erties similar to endogenous bile acids, however, may have slower elimination kinetics and remain persistent in the body due to enterohepatic recirculation (EHC).31
The EHC is a normal physiological re-absorption mechanism for recycling bile acids and acts as a means to conserve required biological compounds; this mechanism, however, can act as a hindrance to elimination of some toxicants. After hepatic process- ing, delivery of toxicant compounds into bile with subsequent excretion into the intestine accounts for much elimination. In addition, some compounds appear to be delivered directly to the lumen of the intestine by exfoliation of the epithelium or exudation across the mucosa.30 Unconjugated compounds released into the gastrointestinal (GI) tract as well as conjugated toxicants freed by the action of enteric micro-organisms, however, become available to be re-absorbed and return to the liver through the EHC. Consequently, the cycle of excretion and re- absorption commences over and over again. The net result is that the process of recycling toxicants results in (i) repeated elimination by the liver thus consuming energy and nutrients, (ii) it severely prolongs the half- life of involved toxicant compounds, and (iii) it increases the potential health risk because of retained xenobiotics and persistent exposure. [/i]
Human & Experimental Toxicology.pdf (289 KB)