Progesterone treatment?

Therapeutic Efforts Pharmaceutical
#1061

You are completely right. I guess we just have to try it out ourselves. Now im trying to choose my last shot. Either TRT or Progesterone, if i can decide which one upregulates the AR’s on prostate.

Here is a messsage i got from a pharmacologist and a bodybuilder who studies medicine and knows a lot of good information.

Upregulation through antagonists is a common phenomenon but with nuclear receptors I wouldnt be surprised if it can differ from receptor to receptor. I don’t see evidence of direct antagonism from progesterone. Could be a downstream effect. Not sure though.

@BibFortuna

1 Like
#1062

Yeah man, please, open a thread or something, what kind of improvements you have right now? Neato!

#1063

If I had to choose, I’d rather progesterone, because it will boost all downstream hormones balanced way.

Besides direct action (membrane receptors and nuclear receptors) progesterone is a precursor of a bunch of hormones. So your body will experience effects from all of them. But it won’t necessarily be noticeable. Also, you have to know what membrane receptors’ action is very rapid (hours), whereas nuclear may take days to develop. And any effect may not be consistent because of the body’s constant recomposition and rebalancing. I read about different effects at different timeframes during hormone exposure: 1, 6, 12 hours. And after withdrawal.

Not sure if you need this information, but I guess when you shooting in the dark any clues are useful.

1 Like
#1064

Yeah thanks, well, the cascade of other hormones, neurosteroids, it seems i don’t need them. I am already on HCG and i saw zero benefits. My only issue seems like a hardcore prostate damage. Insensivity of AR’s there. Mental libido is fine.

Very weak studies with bleak conclusions. First one is done on breast tissue of females. Second one on rats and reptiles. And does not clearly state Progestins effect on AR’s.

It seems inhibitive to androgens and AR, but not every inhibitive action results in the upregulation of the AR’s on target tissues…

I wish i was PFS, lol! It would be much easier to recover. I would know what to do to cure myself. PAS is even worse than PFS, i feel like so unlucky about my fate and life. This is so sad, at least im a mild case…

#1065

" I wish i was PFS, lol! It would be much easier to recover. I would know exactly what to do to cure myself. PAS is even worse than PFS" Is this a joke?
First of all, no you wouldnt know exactly what to do to cure yourself. Or if you do, go ahead and tell everyone what it is so we can all leave this forum and live our lives.
Second of all, PAS in not worse than PFS. Thats a completely baseless comment.
You need to start putting a bit more thought into your comments, especially since the forum is flooded with them.

#1066

I said ‘‘myself’’. I would know how to cure myself, if i had PFS. At least, what to try. Everyone is different. Man please don’t cheerypick my words all the time. What are you trying to accomplish here? Im just trying to help. Yes my comment might sound a little bit annoying, i agree. And could sound over the top.
But i don’t think if you are aware how bad PAS also is. It changes from person to person. You sound like you haven’t seen different boards, check out Acne.org and other PAS cases.

Can i ask what are you doing to cure yourself? Are you aware that your neurosteroids are lacking due to PSSD and HCG can cure you? Have you heard the Dexa recoveries on PSSD forums? Have you heard the HCG recoveries? What are you planning to do here, are you waiting a research to happen and find the magic pill? Im just asking. I know many recovered PSSD cases.

#1067

Theres a difference in saying you know what you would want to try vs you know what would cure you. Noone (including you) knows anything for sure regarding whats behind these syndromes, let alone knowing how to cure them. Secondly, if you know your comment is annoying, dont post it or then word it differently. Lastly, I know that PAS is bad and I have been on different boards. That doesnt change the fact that you comment was baseless.

Regarding myself, Im the last person to be waiting for research to find “a magic pill”. Ive tried (and am still trying) several things, including TRT, clomid, tamoxifen, etc. Regarding HCG, I havent seen anyone in the pssd community say it cured them. As for dexamethasone, Ive seen a couple of people say they got a window on it, but it didnt cure anyone either. Are you aware that you dont know anything about this condition (even if you claim you do)? How do you know that my neurosteroids are lacking? Your comments are baseless.

#1068

Still very early days man. I will be sure to make updates in my thread later down the track. No changes in sex drive or libido thus far. Erections are stronger however, and I do feel more energetic, better stamina, stronger, etc. I’m just giving it time and being patient before giving a formal update. The body takes time to change. I’ve spoken to people outside of Propeciahelp, who cured themselves with TRT, but it just took them time, one fella it took 6 months… Just gonna be patient. I do think an extended run of HCG should be trialed first to repair neurosteroidigensis. I personally was on HCG for 3 months in 2019.

@Cooper

#1069

Did you try the progesterone cream yourself? And did it work?

#1070
#1071

Closing this topic to reflect the new rules about how to self-report therapies. Read more here - Changes to propeciahelp towards a more effective patient advocacy: Please read this important post about changes to our terms of service