Just like with Accutane, imagine never needing an SSRI to begin with.
Still looking at this same strain here.
First of all,
Tryptophan is an essential amino acid necessary for the synthesis of serotonin, melatonin, and niacin. Low plasma concentrations of tryptophan have been associated with clinical observations of insomnia, anxiety, and depression.
The plasma tryptophan ratio predicts brain tryptophan uptake and serotonin production. If this ratio is low, serotonin function may also be low.
The microbiota could contribute to the pathophysiology
of IBS through a number of mechanisms
; similarly, numerous hypotheses have been invoked to explain probiotic benefits in IBS. These include anti-inflammatory effects, modulation of intestinal transit,
motility and sensation, as well as alterations in the intraluminal milieu via deconjugation of bile acids, generation of
short chain fatty acids and gases.
It should also be noted, in addition, that bacteria can produce
neuroactive compounds. Of these, serotonin may be of particular interest, given biopsy evidence of defects in serotonin
signalling in the gut among IBS patients, as well as evidence that B. infantis 35624 can increase plasma concentrations of tryptophan, the precursor of serotonin. Although
meta-analyses suggest that selective serotonin reuptake
inhibitors do not significantly improve IBS symptoms, serotonin delivered locally by bacteria could be more effective.
solely relying on stool sampling as a proxy of mucosal GI composition and function may yield limited conclusions .
^Going back to this, Im not sure if there is another commercially available probiotic that was isolated directly from the GI tract, not the stool.
Bifidobacterium longum subspecies infantis 35624 (B infantis) is a commensal microbe originally isolated from the human gastrointestinal mucosa.
Bifidobacterium longum subsp infantis 35624 (B. infantis) was originally isolated from resected human healthy gastrointestinal tissue about 15 years ago.
It could be a matter of duration and dosage.
You would also possibly zero in on Bifido species because of its possible importance and selectivity from birth.