How is that difficult?
The cost of 50,000 mg of pregnenolone gel made in this way, which is a life-long supply in most cases, is about $100.
I slathered on a whole bottle of pregnenolone last night. Mentally i feel very good today. It’s a shame it’s so expensive.
There ya go. Now, you should consider making your own pregnenolone gel to save money and avoid to take pregnenolone baths several times a day.
In no way do I wish to tell anyone what to do or not to do (because if I had solid answers to the PFS problem, I wouldn’t be on the board anymore), but I do feel obligated to mention the following regarding pregnenolone.
(For those not interested in reading the math below, the main idea is that a few mg of absorbed pregnenolone will send hormone levels multiple times above the top end of the the range.)
According to the Mayo Clinic, the acceptable range for serum pregnenolone is 33-248 ng/dl. The average human body holds ~5.6L of blood, or 56dl. To achieve 33-248 ng/dl in 56dl of blood, a person would have 1,848 - 13,388 ng total in his or her blood stream. Considering that 1mg = 1,000,000 ng, the absorption of 1mg of pregnenolone (whether 1% of 100mg applied preg is actually absorbed, or 100% of 1mg) could potentially boost serum pregnenolone by 17,857 ng/dl. In other words, 1 mg of absorbed preg will take you above the standard range of serum pregnenolone, with each mg of pregnenolone absorbed accounting for an additional 1.3 times the upper part of the pregnenolone range (i.e. 5mg absorbed pregnenolone will take you to 6.5x the top end, or to 1,612ng/dl).
I realize I don’t know the exact absorption rate, and there may be other mitigating factors. However, people have the right to know how the addition of a hormone (or inhibition) may be affecting them.
No, it hasn’t improved ED at all, if anything that’s worse today but i felt level headed this morning.
Everybody gets worse ED and libido on pregnenolone only (maybe after a temporary boost). Without thyroid supplementation, pregnenolone will only help with neurotransmitter-only side effects (brain fog, depression, anxiety). With thyroid supplementation, it will boost your metabolism and help with testosterone-related side effects too (but, at this point, it becomes damn hard to dose).
Dear Former,
If, instead of pretending to be a brilliant academician, you had looked up blood tests of people who actually take pregnenolone, you would have realized that your reasoning is completely wrong.
For example, after taking 200 mg of transdermal pregnenolone 3 times a day for a month (which is a lot), I took a blood test and measured pregnenolone. It was 199 ng/dL (23-173). The blood test was taken 2h after a 200 mg dose. Recently, I took a blood test 4h after a 500 mg TD pregnenolone application. It was 230 (23-173).
Therefore, there is no way that each 1 mg of absorbed pregnenolone accounts “for an additional 1.3 times the upper part of the pregnenolone range (i.e. 5mg absorbed pregnenolone will take you to 6.5x the top end, or to 1,612ng/dl)”.
Your reasoning is wrong because you didn’t consider that pregnenolone gets converted in many hormones, some of which (cortisol) can be consumed very quickly. Beside wasting your time with this meaningless idea, why don’t you waste some of this time to look at people’s experience? I find it more accurate that 100 papers.
M81 -
I conceded that I don’t know how much pregnenolone is absorbed. Maybe from 200mg only .5 mg is absorbed? However, nobody knows for certain. And yes, pregnenolone does get converted into many hormones (including estradiol), but the conversion is likely not instantaneous. Because pregnenolone is converted into many hormones, pregnenolone cannot be viewed as “just another supplement.”
I’m not trying to say “pregnenolone doesn’t do anything” or “cannot provide any benefit,” but rather give some insight into what could (and I stress “could”) occur.
There really is no need for you to be defensive; I am trying to provide constructive feedback and am not making a personal attack. The “singular experience” method is what causes many people to still defend finasteride as safe. One person’s experience cannot necessarily be transferred to another person. Additionally, maybe we should take the approach of discounting all those scientific papers. In that case, finasteride is probably extremely safe and we’re just a bunch of Munchausen enthusiasts.
I’m not sure why you are so mad, maybe you are a pregnenolone shill?
Before i used preg i had brain fog and could ejaculate.
I used preg and still had brain fog but could not ejaculate, was told i need thyroid meds because “the thyroid couldnt keep up”, and would be able to once again ejaculate once supplementing t3.
Which would get me back to where i was pre preg.
Does anyone see how fucked this is? Preg is not the answer.
Were you taking up to 800 mg of transdermal pregnenolone in a single dose? Probably not. If that’s the case, you were not taking enough pregnenolone. If you take enough pregnenolone, brain fog is guaranteed to lift. Mens Rea has recently noted mental benefits by taking 800 mg. He had no benefit at 400 mg. Similar experiences are reported on muschechatroom.com. Note that most people report a worsening of ED on pregnenolone ony. That’s part of the game. Once you add the right amount of T3, it gets better.
Pregnenolone is NOT the answer. No hormone, supplement, or product is the answer by itself (otherwise, we would have already found a cure).
Nevertheless, a pattern seems to emerge from some recovery stories: “Keeping good levels of cortisol and good levels of thyroid hormones can either cure you (robocopp, correiovip) or allow T supplementation to restart your system (Dury, JN)”. The best way to increase cortisol is through pregnenolone AND thyroid supplementation. As far as I understand, you are choosing to ignore the thyroid part.
Mens rea says on this forum, he doesnt have any mental sides, “really feels for the guys that do”. And musclechat, who cares, it has nothing to do with pfs.
Oops, you are right. He was actually talking about an improvement in erections.
Why are you assuming that we are different from people that have our same sides and same response to androgen supplementation, but who never took any drug in their life?
Yeah, as Tim said i’ve been lucky in that respect.
As for my experience with preg:
Well firstly i tried the 1% stuff a few months back. I got small improvements in libido and erection performance. I stopped it. It’s strange but for 2 weeks AFTER i stopped i had a really good period - improvement in all areas and excellent ejaculate. Penis was much more fuller. THat soon abated back to base.
I later got my own 10%+ TD preg and this stuff wouldn’t work for me at all even when i took 400mg 3 times a day. WTF. I got pissed and tried a 800-1000mg dose last week. I had erections all night (i did take a cialis though) and definate burst in libido. All was great until that night when i noticed my penis looking even more malnourished and my erection was needle thick. My ejaculate was very watery. I think that use of preg crashed me a little.
Chillin tells me i used up all my thyroid hormones but this seems unrealistic after one dose. I dunno. My thyroid profile (pending RT3 testing) is pretty much perfect i doubt it’d be depleted after one dose of preg. Although ive got T3 starting it on a whim seems a little risky.
I wish i could try the whole preg+T3 thing under good medical guidance but right now that aint an option for me so im not sure what to do, really.
TO THOSE NOT HAVING RESULTS FROM TOPICAL PREGNENOLONE
Don’t throw your tubs away just yet!!!
Instead, rub it on your pecker!!! It might help with nerve regeneration
Read this
longecity.org/forum/topic/7954-nerve-regeneration/page__view__findpost__p__79183
I rubbed mine there anyway, assuming absorption would be best. It’s ashame it’s so damn expensive.
Longecity is a great forum btw.
I think it is fucked, yes, but it is how the body works. You need thyroid and vitamin A to convert preg downstream to testosterone and the other hormones. If the thyroid is all ready fucked, then maybe we are having a bad reaction to preg? It is possible PFS relates to a very poor thyroid function if when we take preg, our body is unable to use it?
Also, preg should be taken with DHEA, low dose of 5mg to stop the possibility of estrogen conversion, it’s possible that is a potential problem as well.
Sorry to bump an old thread, but it is important.
Has anyone else tried preg? Anyoen experimented with it with thyroid in the past? No i’m not advocating it, just asking.
Preg fucked me. Gave me progesterone dominance
How do you know this is what happened? Did you get blood work done to show this? Didn’t you say your blood work was perfect?
An old thread but my experience with preg was very good at the beginning. 3 months ı was feeling great. That was from December 2019 to March 2020 where I took pregnenolone, dhea, progesterone cream. Ashwaghanda and some other stuff. But then pregnenolone started to give me heavy migraines. Took me over a year to figured out that pregnenolone was the reason for the migraines. I cant explain why it did not at the beginning.
So, pregnenolone gives me incredible confidence and erases my negative mindset and social anxiety. But gives me huge migraines. After 2 months off, I tried 10mg yesterday (life extension brand) and was fine. 10mg this morning and I started to get these inflammation sensations in my brain again. And now I feel a migraine is starting.
This makes me so sad because finally I had a cure for my social anxiety but then I have to live with crippling migraines that come twice a week.
I might add 5mg Lithium orotate because I read it is great for migraines.