Very interesting study on the effect of lysophospholipids and their effect on 5 alpha reductase on human prostate cells:
Phospholipase A2 degradation products modulate epithelial and stromal 5-reductase activity of human benign prostatic hyperplasia in vitro
www3.interscience.wiley.com/jour … 1&SRETRY=0
Recent studies have demonstrated the inhibition of 5-reductase activity in human prostate by phospholipases. Among those phospholipases, phospholipase A2 cleaves one of the acyl chains from phospholipids, thereby producing fatty acids and lysophospholipids such as LPC, LPS, and LPE. Therefore, we were interested in the effect of those lysophospholipids on 5-reductase activity in human benign prostatic hyperplasia (BPH).
In epithelium, LPC at low concentration yielded a dose-dependent stimulation of 5-reductase activity up to 167%. At higher concentrations, epithelial as well as stromal 5-reductase activity was inhibited significantly. As indicated by results of enzyme kinetic analyses, the LPC-mediated activation in the epithelium results from an increase of the active population of 5-reductase.
LPS stimulated epithelial and stromal 5-reductase activity; this stimulation was significantly stronger in epithelium (296%) than in stroma (163%).
In the article they talk about how a particular phospholipase (phospholipase A2) is able to break the acyl chains from phospholipids, thereby producing fatty acids and three lysophospholipids: LPC, LPS, and LPE and their differing effects on 5 alpha reductase activity.
I haven’t been able to read the entire article yet.
Whether this is better than dilauroylphosphatidylcholine or bovine phosphatidylserine i couldn’t say, however this is a study demonstrating that phospholipids have an effect on 5 alpha reductase in human prostate tissue, which makes it quite exciting i think.
That’s if i’m reading it correctly.
It’s all quite confusing with all the phospholipids/phospholipase/lysophospholipids.