Novel Penile Ultrasound Technique to Explain Mechanism of Erectile Dysfunction (ED) in Young Patients using Finasteride for Androgenic Alopecia

Science PFS Research
#35

The idea is that all our problems are related to a lack of androgenic signaling and as @Axolotl has pointed out, there is reason to believe that the return of proper androgenic action may result in a reversal of our symptoms. This is supported by the brief honeymoon periods that some people experience during the use of anti-androgenic substances. People have described quasi miraculous recoveries on such substances, which toally makes sense in the light of the theory that is currently investigated.

Sage Therapeutics is targeting the market for depression treatments. This is a multi-billion dollar market. Of course, they are not interested in doing a trial for a small group of patients that suffer from a very rare condition that is not widely accepted and often rejected. That’s because commercial drug development is highly expensive and there is no additional benefit in including us. If they capture the market for anti-depressants they’ll make billions. Why would they waste any time on a small and irrelevant group like ours?

The fact that we as a community are so small and irrelevant is why the admins here have decided to branch out. As you may have read here already, it turns out other conditions are likely driven by a very similar or identical mechanism. Hence, it makes sense to join forces with the respective communities to make our problem bigger and more relevant. The more relevant we are, the more resources we can gather for our cause. That’s why everyone from these communties needs to support the survey and 23andme project.

Still, it is unlikely that a drug will ever be developed specifically for our condition. However, our problem is closely related to key issues in prostate cancer research. And billions are invested in prostate cancer research which may result in benefits for us.

While a drug may never be specifically developed for us, we may get lucky and profit from efforts in prostate cancer research or may have at least some therapeutic benefits from developments like Sage-217. But there are also technologies like Crispr that are fast becoming powerful yet cheap tools that may not need billions of developmental costs to be applicable to us.

@Axolotl has explained it in a different thread:

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#36

This thread is too doom and gloom. Myself and many others have experienced full recoveries at times. My longest lasting was from cyestine and histadine, actually. I got everything back within DAYS. It was miraculous. Oilyness, drive, sexual health, hair loss. All within 3 days a flip was switched. And this lasted for many months and may have last for much longer if I didnt mess around with minox and 5htp. Theres many other things I’ve done that have helped as well, but one thing that was made clear was just because I was “turned back on” didnt actually mean I was healthy. I just had the opposite problem. I was too sexually stimulated and had too many dht symptoms. We need to find the middle. I’m more balanced now but not 100% where I want to be, and I’m fighting fibrosis with shockwave, which more should get on (I think everyone) as a preventative as it is the only researched solution.

I know we can reverse it. But i dont want to just reverse it back to how i was before. I want to be healed. And that is a much more complicated picture.

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#37

CRISPR do it only in China and not on humans.

#38

I wonder if the same results would appear in men who have ED not caused by pfs (something crazy like 1/4 have it). Especially if they had it for a while.

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#39

Can u tell your “genital story” here briefly please? I tried to find yours but couldn’t manage to do so.

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#40
#41

Exactly what do you want to know?

#42

Your sexual sides after quitting the drug. I dont even know if the 1st doppler pic was right after crash or so^^. Just like… your penis history after crash.
Can or could u achieve errections and your situation got worse, or got it worse during ED periods. Or had u full ed after crash etc.

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#43

Call me old-fashioned, but in my day you had to take someone out for dinner and drinks first before asking these types of questions.

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#44

lol :smile::smile::smile:

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#45

In case of the aptosis of corpora cavernosa, tunica is unaffected, right? Does it mean the placement of penile prosthesis can restore the former glory and size?

#46

just came across this

burst out laughing

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#47

Why brother?

#48

I’m surprised more people haven’t tried Shockwave. I think this may help halt and improve the penile fibrosis / smooth muscle damage many of us are experiencing as long as enough sessions are done (practitioners seem to suggest 12 sessions + PRP for severe ED). Results are extremely promising for this treatment. A few of the forum members have tried it with mixed success but you have to stick with it for multiple sessions and add PRP get the full benefit. Our lack of morning wood and infrequency of strong erections may be causing some of the apoptosis / smooth muscle damage due to low NO release over time (see below). I’m probably going to do the shockwave and add daily low dose Cialis for a while. This may be the missing piece in my case.

“Nerve injury or reduced nerve function results in reduced Nitric Oxide (NO) release available to the smooth muscle of the penis. Lack of (NO) causes reduction and loss of smooth muscle cells in the penis and increased fibrosis in the penis causing venous leak resulting in ED. Treatments revolve around penile rehab and daily PDE5 inhibitors to improve penile blood flow”

"There are several different theories how penile shockwave therapy enhances penile erectile function. While all theories may differ in mechanism, they all point towards improving penile blood, improving vascular growth and renewal, improving nerve function and breaking down fibrotic tissue within the penis to enhance erectile function.

The most prominent hypotheses behind shockwave therapy for the treatment of ED stems in part from the therapeutic uses of shockwave waves to induce angiogenesis (new blood vessel growth)."

"Shockwave therapy has the potential to activate dormant Schwann cells (nerve cells) within the dorsal nerve of the penis, activation of endothelial cells and improve nitric oxide release to enhance vasodilation during erotic stimuli."

#49

tried 12 sessions… not sure if it helped but didn’t harm anything

cialis also helpful

my thinking is that our hardware is fine, but its the software where we have an issue. Ie i have had moments of v strong morning wood without any supplements or cialis. Presumably if you can do it once you can do it all the time in theory. I thing its something to do with how our hormones regulate NO production in our penile tissue

4 Likes
#50

Tried 17 shockwaves + 2 prp’s.
No lasting effect (but there was a quite clear temporary effect for around a month).
https://forum.propeciahelp.com/t/dr-irwin-goldstein-from-san-diego-sexual-medicine/9147/53

#51

Any word from demon?? I hope he is doing better!

#52

Sorry I don’t understand, what’s the distinction between being healed and reversing the condition. Aren’t they functionally the same?

#53

Same here. My Doppler shows heterogeneous tissue, enlargement of tunica albuginea thickness and hypoechoic regions with low vascularity leading to low elasticity of the erectile tissue and, therefore, secondary venous leakage.

1 Like
#54

Tissue specific, not serum. That’s probably the key.