Nicotinamide Mononeuclotide

General Discussion
#41

Anyone who is interested in trying NMN, I would highly recommend listening to Dr david Sinclair and maybe reading his book called “Lifepsan”. I recently wrote a post about treatments for longevity potentially being able to cure syndromes like PFS and PAS of they are due to epigenetic changes.

Dr David Sinslcair takes 1g of NMN each day. However, if you want to try NMN, you shuold also try 1g of resveretrol with it. NMN is a precursor to NAD which acts like fuel for the sirtuin genes/enzymes. Its this set of genes that provides all the benefits of NMN as they can repair DNA and also reverse DNA methylation etc.

NAD is the fuel for the sirtuins but resveretrol acts like a foot on the accelerator of the sirtuin genes. So they make a great combination. Also, if you take NMN, you need to keep it refrigerated as it can degrade quite easily.

It is highly recommended to take resveretrol and NMN with some greek yoghurt and fats such as olive oil as this signficantly increases the bio-availability/absorption of both of these compounds. I believe the difference in some cases was up to a 5x increase in blood concentrations.

#42

Hey so you don’t think the NR was the main reason you started recovering? It sounds like from this thread that you took that and everything started improving and then the added l-dopa nad trib started helping on top of that but here you’ve listed the l-dopa and trib as helping more than the NR. Any thoughts you can share? Thanks a ton for documenting all of this man

Edit: Also, did you stay on the high dose (4 pills in the morning and 4 in the evening up until now? So for 4 months? @lowestprime

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#43

It’s hard to say, but I believe the majority of my improvements actually came from (in order):

  1. my 1 month cycle of L-dopa (which I started after attempting to fix things with NR)

  2. followed by a reintroduction of Tribulus and Cistanche

  3. and then finally increasing my E2 back up to the normal range with soy isoflavones and pregnenolone (as well as the removal of Tongkat from my stack, I think this alone would have been sufficient to raise my E2 given enough time, I’m just impatient).

I’ve been off NR for a few weeks as it wasn’t doing much for me and as I’m sure you know, is quite expensive. I only took the high dose for a few weeks and then realized I could maintain its benefits by taking the normal recommended dose, especially since I’m already 23 and practice intermittent fasting pretty regularly (i.e. my NAD levels are already pretty optimal despite any residual PFS sides).

#44

How much was the high dose you were taking? Also was it all in pills? I couldn’t find a powder form anywhere.
I took one pill of 300mg as directed for 2 or 3 days and noticed nothing from it. I’m planning to go back and try it again but from the few stories I read the benefits were pretty instantaneous so I’m a big discouraged

#45

I mentioned how much above (1200mg twice daily)

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#46

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#47

FYI, maybe dm me etc instead since it appears they might be closing this post

#48

Can I suggest that you use the self-reporting form instead? It shouldn’t be challenging and you can just direct @JustTrynaMakeIt to follow your experience in your member story and ask questions there. It will also allow other users to continue following along with your experience.

#49

Have people got worse on these supplements? Should I test those?

#50

Maybe talk to @Mercked?
It seems they had a negative experience with NR/NMN, see above.