Here is some info on Modified citrus pectin and its link with orexin:
selfhacked.com/2014/02/12/how-to … _is_Orexin
Modified citrus pectin is a “GLP-1” increaser.
GLP-1 is a gut hormone that can activate/excite orexin neurons in the hypothalamus (which increases orexin).
It’s possible that GLP-1 could function like orexin and work instead of it:
Orexin, also called hypocretin, is a neurotransmitter that regulates arousal, wakefulness, and appetite.
Narcolepsy is caused by a lack of orexin in the brain due to destruction of the cells that produce it ®.
The orexin system is central to us functioning as productive human beings and being in a good mood.
Orexin increases our metabolism and body temperature, so if you’re feeling cold and tired, low orexin is partly at fault.
Orexin increases hunger, and this works via increased neuropeptide Y expression in the arcuate nucleus of the hypothalamus.
This orexin system interacts with so many other systems of the body, which makes it so important.
High levels of orexin-A cause us to be happier. The incidence of depression is higher in narcolepsy.
Animal models show that low levels of orexin cause obesity -even when they consume fewer calories.
This is a significant factor in why consuming sugar makes us fat. When we eat sugar it causes our blood to spike in sugar. This suppresses orexin, which makes us fatigued and inactive. So instead of burning the calories, we go to sleep.
Orexin and its receptors declines with age.
Orexin causes us to increase oxygen consumption because it increases metabolism