Hi Alex,
How’re the HDAC inhibitors working?
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Hey man,
i suppose you are headsup?
if correct, we can initiate a debate!
I hope you returned just to check the site and you still doing well.
Yeah I’m Heads up!
A debate lol…What about?
I’m feeling pretty good😁
i’m really glad for you! 
I couldn’t add neither brocolli nor camonille nor garlic. Just potatoes, meat and oats and almond milk. The rest crashed me heavily…
(i got really impressed to crash on those simplement foods)
My modifications are
Sometimes i use normal milk.
I do intermittent fasting
i have to take an SSRI
and i’m taking metformin, which lowers testosterone but degrades AR mRNA
i’m killing my recovery doing that?
Shortly after making that post I ran a microbiome analysis, the results were interesting - turns out I have the bacterial profile of somebody with chronic fatigue syndrome. My focus consequently shifted to fixing my microbiome and I have not been consistent with the HDAC inhibitors. I plan to run a course of HDAC inhibitors in the future, likely Tributyrin, Lithium, Beta-HydroxyButyrate, Raw Unmodified Potato Starch, and the foods I mentioned earlier, however this will be at a later date once I fix my microbiome. I don’t like taking too many things at once. Better to have one focus area at a time in my opinion. Good to see you back!
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did you try out your theory? Any results?
Hey yes keto is the way to go. I can’t eat carbs anymore as I get immediately stuffy and brain fogged and my dick goes cold.
I just read a study that backed up my theory. It states that tnf alpha and the eventual NADPH oxidase upregulation will directly damage the penis.
Interesting that suppression of TNF with a drug called Infliximab improved erectile dysfunction.
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I know nothing about this
Will this TNF damage the penis even in none PFS patients?
Are you saying poor choices in diet can actually make you worse apart from the traditional reasons why?
Yeah it could. IIRC it’s elevated in Peyronie’s disease.
Hey, @Stronguy anything new to share? Although I don’t understand anything about the science behind it, ketosis has been the closest thing to fixing my symptoms, the higher the ketone levels, the better I feel, so I think you are on the right track here.
I wonder if you know anything about HMB or Leucine? Both seem to increase ketone levels as well as MCT oil… Do they have any effects that would be beneficial according to your theory?
Also, what is your view of Niacin to raise NAD+? Do you think it could benefit us? I feel a lot better taking fast-release Niacin in high doses when I’m eating carbs, but doing it on ketosis is super hard…
Anyway, would appreciate any thoughts you might have on all of this.
Hey, @Stronguy anything new to share? Although I don’t understand anything about the science behind it, ketosis has been the closest thing to fixing my symptoms, the higher the ketone levels, the better I feel, so I think you are on the right track here.
I wonder if you know anything about HMB or Leucine? Both seem to increase ketone levels as well as MCT oil… Do they have any effects that would be beneficial according to your theory?
Also @surviveplz , very interesting the exogenous BHB supplement you mentioned. What makes it different from the current esters in the market? I see that it has a very prolonged effect, lasting up to 12 hours… is that why it’s superior to what is currently out there?
Anyway, if you guys could give your thoughts on this I would appreciate it.
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Yes taking real fast release Niacin will deplete your carbs faster as it shuts off lipoysis, putting you into a deeper ketosis. It will also increase growth hormone and I vaguely remember it is an HDAC inhibitor and reduces ROS. It is a good supplement. I too feel much better when I regularly take Niacin. best taken before gym or bed to amplify the growth hormone response.
Those other supplements will provide your body with ketones yes. But I believe the best way to increase ketones is to fast.
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