I was stumbling upon a blogger who is quite knowledgeable about the male body.
Anyways, all this reading has made me come to a hypothesis that our condition is caused by excessive damage by our own body, mainly superoxide and ROS. These inflammatory markers are healthy in moderation but excess can cause damage to our brain, enzymes, blood vessels etc. We may overlook it because we are young and think that this damage shouldn’t effect us now, but it can happen at any age.
I have done my genetic test and I have a gene that causes IL-6 to be over-expressed, which increases superoxide. Many of you may also share this genetic trait.
Allow me to go into how ROS/inflammation may be what caused our problems.
NADPH oxidase is an enzyme that creates superoxide (damaging molecule). It requires NADPH, a molecule that is responsible for creating allopregnanolone from 5DHP (Allo is a neurosteroid we have very little of).
NADPH oxidase causes an inflammatory state which will cause an enzyme Arginase to be up regulated. This enzyme competes with Nitric Oxide Synthase (NOS) for arginine as they use the same substrate. NOS is what causes erections, so if Arginase is taking away arginine from NOS due to the upregulation by inflammation, nitric oxide will not be produced. This explains why perfectly healthy guys are getting ED. In fact, arginase activity is associated with CVD and many other diseases. To inhibit arginase, you can use Ornithine, citrulline, coffee, tongkat ali and/or rhubarb. Ornithine works well for me on an empty stomach.
NADPH oxidase is the next enzyme that needs to be inhibited. It is stimulated by inflammatory markers like IL6 and TNF alpha, alcohol, excessive body fat and glucose. Inhibitors of NADPH oxidase are nitric oxide (cialis) and apocynin (found in kutki/picrorhiza kurroa) and a ketogenic diet, likely because of BHB and butyrate.
Big scavengers of ROS/superoxide are upregulated on a ketogenic diet and fasting or both (exercise as well). The ketones actually reactivate silenced antioxidant genes by inhibiting HDACS. Niacin seems to be a great supplement as it also blocks ROS and supplies NAD for NADPH.
With NADPH oxidase inhibited, it will allow for more NADPH to be used in the conversion of 5DHP into Allo.
TLDR, my thoughts on fixing PFS:
- Inhibit NADPH oxidase to reduce inflammation and also Arginase
- Do this by getting into a ketogenic state via fasting or exercise or both to inhibit NADPH oxidase and arginase. Exercise also upregulates ROS scavenging enzymes such as superoxide dismutase (SOD).
- Supplements to help is BHB, Kutki, niacin, ornithine, coffee, rhubarb, tongkat ali, cialis (only when arginase is inhibited)
Let me know what you guys think on my superoxide inflammation theory.