My problem...............advice anyone?

I know. What really annoyed me is the fact i put forth a good argument mentioning the study being done confirming it, Dr Jacobs experience, and the fact that I had all these symptoms but he had already made his mind up before i entered the room and was not even considering it as an option. He acted as if Dr Jacobs was not a respectable doctor when he clearly is.

The arrogance in thinking he knew it all was outstanding. The more i argued the more fuel for his psychosexual babble. He didn’t seem to notice the fatigue and the other non sexual symptoms. Ridiculous! He hated the fact i challenged him. Twit.

Dr Jacobs and self medication is the only way to go it seems.

Ah crap! Woke up today with muscle twitching. All over. Stopped doxycycline as I’m getting bloods done next week and don’t want this to interfere.
Its annoying and a worrying sign. Don’t think its serious like MS or MND but distressing nevertheless.

Decided to stop taking doxycycline. Been off it over a week now and all symptoms worsened. It did give me some functionality and has shown me that my condition is at least in part reversible. However, been doing reading on it and long term use is associated with a black thyroid and therefore an increased risk of thyroid cancer. Also although it helps it is not a cure. I hope others see if helps them even if only for a brief time.

Its a hard decision as it has given me some quality of life back and to go back into the cold as it were is never easy.

Things I’ve noticed after stopping doxy:

  • decreased libido
  • decreased quality of sleep
  • hard to get up everyday
  • shrunken genitals
  • increased visual issues
  • increased fatigue
  • different prostate discomfort
  • starting to feel more depressed and forgetful
  • drier mouth - this is what i think makes people complain of teeth issues

So tempting to go back on it but want to stay off it.

did you think of TRT+HCG+arimidex?

I’m against messing with hormone levels if they are normal. Will have full profile back in next couple of days.

Why mess with hormone levels if they are normal - could worsen situation. Am in androgen resistance boat of thinking. Only a few have improvements on TRT - does not solve problem. Simple as that.

Sure if you have a low free T then it might help etc… But if everything is dandy does it not make more sense to try and restore sensitivity than overload it which could further reduce sensitivity to testosterone.

My research has pointed away from messing with hormones and more to messing with what regulates sensitivity. Many people don’t like that theory but scientifically it is by the far the most sound.

If TRT worked this forum wouldn’t be so active. It does help some people but don’t believe it is a cure and is risky.

Noticed:

  • slightly slower beard growth
  • back acne not as bad

General signs that androgens aren’t doing as much which if affect 3 alpha HSD pathway - explain worsening sleep and mood changes.

I’ve been currently applying DHT gel (Andractim), and it’s my 19th day on it.

I don’t know if it’s worth going on (My doc planned two months). I’m afraid to desensitize me even further.

Curiously, he thinks that putting exogeneous DHT will awaken the receptors.

Group A thinks less of an hormone will upregulate the AR sensitivity, and more will downregulate the sensitivity (the majority)
Group B thinks less of an hormone during a long time will put the receptors asleep, and more will awaken and upregulate their sensitivity (my Doctor is in this group)

Honestly, I don’t know what to think.

Edit: Interesting: ttp://www.mesomorphosis.com/articles/pharmacology/androgen-receptor-regulation.htm

I’m in Group A. Overall peoples experience long term with TRT or hormonal therapy is that it wears off.

Just had Vitamin D test back and I’m severely deficient. No surprise there. I was supplementing in the summer and had normal levels. Time to go back on it.

Normal is above 50. Severe is below 15. I was 11.

Y-C
no body is expert here but you can benefit from people who are on TRT already but from people on messo or musclechatroom etct you will not learn any thing. they are on TRT but if you dig them deep you will be surprised that they were not naturally low on T. when I talked to them almost all of them have used herbs or fin in the past.even some used saw palmetto. Here in our board only Awor and Whalen72 are good examples. Awor was naturally low in T while Whalen used steroids but they were fine for years on TRT. Whalen was for 10 years (better pm him)on TRT with no problems, problems started after fin.
where are you applying DHT? I was thinking if I had it , I would apply only in small quantity in genital area but since I am in Canada I can not buy it.
in youtube ,DHT is darling for many FTMs.

sps

I seriously lack of Vitamin D too: 10ng/ml instead of 30 minimum.

I was prescribed 5mg on genitals, so I apply 2,5mg on penis and 2,5mg on scrotum.

I’m pretty sure it has make me regain some length and girth.

It feels dullest than ever though.

Bloods have come back and everything is in normal limits. Even 3 alpha diol

Even 3-α-DIOL-G which was 1445ng/dL MALE 280 - 1900

Not remotely low. Maybe I hadn’t stopped doxy soon enough. But looks ok.

Everything else so far looks fine - too good even. Thyroid’s all great. Estradiol great. SHBG not high. DHT - upper third range.

With this hormone profile would not want to mess with any hormones. Some more to come yet.

Perplexed about the 3 alpha diol g although makes sense as i am one who still loses hair and gets back acne - this has lessened a little since i stopped doxy but I have noticed although I have dropped back after stopping antibiotics esp. sexually - I am not as bad as I was pre doxy. I’m still not good sexually by any means though.

I take it the vit D you’re using is a topical cream? Is it available over the counter?

I think what this means if we think doxy didn’t change much is that my problem is not very “deep” and therefore more reversible.

Will check 3 alpha diol again at some point. I’ve stopped doxy for good now.

Wow, thats interesting.

I dont mean to harp on but what are your progesterone and preg levels? DHEA etc? Perhaps its further down the chain that is causing the problems. Progesterone is such an important hormone for sexual purposes.

EDIT - I just noticed from the first page - your progesterone IS low

have a read:

Men and Natural Progesterone cream

Dr Lee advises that progesterone is the precursor of testosterone and cortico-steroids, meaning
that the male body uses progesterone to make these other hormones. Like progesterone,
testosterone can stimulate new bone formation so increase bone density, and a lack can cause
osteoporosis. Progesterone is produced in the adrenals and testes with levels much higher in
adult men throughout life than in post menopausal women.

Levels remain fairly constant in men until about their fifties or early sixties when production of
progesterone and testosterone fall and testosterone changes to di-hydrotestosterone with a rise
in estrogen which appears in softer stubble, shaving less and developing fatty breasts. baldness,
benign prostatic hypertrophy [BPH), prostate enlargement and prostatic cancer also appear to
correlate with di-hydro-testosterone. Significantly, Dr Lee reported in 1999 that progesterone
blocks the conversion of testosterone to di-hydro-testosterone.

Further, a 1992 test found that men supplementing with natural progesterone cream also made
remarkable improvements in the ‘male menopause’; mood, libido [sex drive] and DHEA. Natural
progesterone is the source of libido or sex drive in women and markedly increases libido or sex
drive in men.
Suggested use for men:- Apply an eighth-teaspoon (size ofa pea] to the neck at
bedtime for 14 days, discontinue for 1 day, then repeat.

More : wellsprings-health.com/Na…our-Health.pdf

Also note:

From a book written in 2004, by Sighi Drassinower MD : " You need to balance these four hormones: testosterone, progesterone, estradiol, and DHT. A good ratio between testosterone/progesterone/estradiol/DHT is 60/200/1/1".

This might be very relevant to you bud,.

DHEA-s middle of the range. Everything seems fine.

Will wait 2 months before retesting 3adiolg.

I tried progesterone cream a long time ago - did nothing for me.

If prog is helpful it is only due to its conversion into androgens i think as does not directly affect penile size.

And my progesterone was not out of range.

It’s low range.

Remember that these ranges are ridiculous. “Out of range” means very little. You need to interpret the results in light of your other bloods, your age etc. The ranges are simply derived from everyone elses levels and that can include 60year old men and men of all hormonal imbalances. Never forget that.

How are your thyroid levels, though? Preg might be a better supplement for you. I’m just trying to give you new ideas. Alot of guys don’t respond to the prog/preg because they aren’t absorbing it. Your bloods would tell you if you had been or not. If not a boost in your thyroids could help facilitate absorption.

As for the 3-adiol-G, remember its not really the best indicator. Use the uninary ratios analysis that Dr C uses. These are the real measure of the reductase’s base activity.

Have you had penile atrophy like me then?

Penis has shrunk up since stopping doxy but have seen it in good overall shape with doxy. It can come back. It shrinks quickly but the reverse is also true.