19, how long were you on doxycycline, and how soon after you stopped did you get adiol-G measured? Please be precise, describe dosage etc.
There is evidence in the literature that certain antibiotics can raise 5AR2 activity.
Thanks much - kazman
On it 2 and a half to three years. 100mg twice daily
Got it measured about 1 and a half weeks after stopping.
Will retest in a month or so.
upates ? have you stopped? how r u feeling and what are your conclusions based on your expereince?
thanks
sps
Since stopping doxy iāve been getting worse and worse. Sleep is getting bad again - waking up exhausted. Getting odd eye pains again which I havenāt had for ages and a dry mouth. Along with the shrunken genitals etcā¦ - painting distressing picture.
So tempting to restart it. But want to wait a bit longer and then retest my 3 alpha diol.
As to why doxy helped I am starting to think it affects all areas so must impact on androgens in some way - either increasing DHT or modulating a receptor. It helped me more than tribulus even though tribulus boosted my testosterone in a substantial way so it might point to the receptor. Just speculation but canāt see how else it could work - that is unless the whole effect of it was as an anti inflammatory.
I quit after 20-25 days. Size returned to shrink after going off, and insensitivity has been worse than ever since applying the gel (it dulled and numbed my penis even more). No effect on libido, erection, and so on. I seem to be totally immune to DHT.
thanks 19 and Y-C
19 your experience with Doxy points either 5AR deficiency or AR resistance. Since 5ARs work as catalyst is it possible their quantity doesnāt change significantly in normal conditions? We know fin/saw palmetto binds them irreversibly. Is there a way to take 5 AR exogenously?
If there were 5 AR deficiency then I would have a low DHT. This is not the case. It has either been high or normal. Hope that makes sense.
good so then we come back to its metabolism, 3 a diol G.
I think its interesting to note that androgen insensitivity does not need to be complete. Is it possible to have a normal 3 alpha diol and still be insensitive? - i think so. I still lose my hair for example. Some areas might be affected more than others. Not every gene in every cell needs to be silenced.
yes different parts affected differently. I think my left half body part is less affected than my right part. I think some one also has reported the same thing.
New abnormality: High prolactin
Upper end of range 450
My prolactin - 771
When tested previously was 650ish and before that it has been ok. Whats changed? I donāt know.
19,
Because you have had benefits with anibiotics and seem to fade away after you get off them, have you tried hetting tested for MRSA (anitibiotic resistant bacteria)? have you had any cultures done to check for the antibiotics in your system?
mrsa-forum-usa.com/index.asp?action=start
I donāt think its the antibacterial effect of antibiotics that is helping because if it was after 2 years of being on it I would have got better and if the bacteria were resistant I would not have maintained the improvement.
Anyone have any thoughts on why my prolactin is raised? Bit surprised about this as before it has been ok.
Iām at my absolute worst at the moment. Shrunken genitals, crippling fatigue, poor sleep, no libido or erectile function. This is my worst. Going to get prolactin down to see if it helps and Iāve just started back on doxycycline (with vit C) as feeling this bad just isnāt worth it.
Sorry to hear that 19, my sleep has gone haywire over the last week too.
Restarted doxycycline now with vit c too. Feeling a bit better after 10 days.
Hope youre taking probiotics this time.
Thatās awesome! Iām glad youāre feeling better!
Ok i restarted antibiotics a while back and then stopped again. This time i retained some of the features like better penile size etcā¦ Last few days iāve been eating pretty badly though and my prostate is really hurting. I can feel a burning there and my symptoms have worsened a bit.
I donāt know the role of the prostate in all of this. I have been a believer in awors idea yet the prostate does not tie into it very well at all. Iām a logical man and finasteride shrinks the prostate. It does not inflame it. Also my body responds to androgens on the whole just fine. Losing hair - check, i do have some libido sometimes (although prostate discomfort puts me off i think), i can gain muscle. Also high dose tribulus made me lose hair fast, sweat like a crazy person, increased my libido, improved erectile strength - even though it made me feel worse and more tired and increased the pain in my prostate. The other concern i have of awors idea is it involves not just one leap of conclusion but many - and the more there are the less statistically likely it becomes to be true. That being said i look forward to any results he finds and I commend his work as i think it is SO important.
Perhaps the prostate issue is a secondary one. But i am interested in how solonjk and co get on even though i have some reservations about the unknown doctor.
As a medical student i can tell you the prostate is really not thought about all that much even by urologists who only really think about it in the cases of BPH, prostatitis (bacterial), cancer. Chronic prostatitis is not really thought of very highly the same way chronic fatigue syndrome and fibromyalgia arenāt (even though they should be). As for prostate massage there is a very mixed opinion about its use (a urologist told me this - he did offer one in a reluctant fashion) i imagine because its not the nicest procedure to do.