Very good work brother
If everyone could contribute the way you do we would probably have solid treatment protocols by now
You seen Melchangi’s new study, analyzed it, figured out what’s it’s suggesting and you are trying to make a treatment protocol based off of it.
Why is it that out of a whole forum of people you are the only one doing this … anyway awesome
I could add one more thing:
Melchangi’s findings certainly suggest that we could possibly benefit from increasing epinephrine. But there is another way to look at these findings as well. Maybe body is lowering epinephrine to protect us in our 5AR inhibitor induced imbalanced state. Maybe increasing epinephrine will make us worse.
Here is why I’m making this guess:
SAMe is the cofactor that allows the PNMT enzyme to convert Norepinephrine to Epinephrine. Myself and a handful of others took SAMe and got substantially worse specifically with insomnia. Therefore maybe the reason why we got worse from SAMe was working as a cofactor to allow the PNMT enzyme to make more epinephrine from norepinephrine. It’s something to keep in mind. But hell yea we need soldiers who are willing to try it either way.
The only other thing I can add is that dopamine converts to norepinephrine and like we already know the norepinephrine converts to Epinephrine. Well on 7/29/2020 the amount of dopamine in my urine was 129 ug/g. I increased dopamine production for approx 64 days and by 12/5/2020 my urinary dopamine increased to 163 ug/g. My norepinephrine which is next in the cascade increased as well. But guess what ! My urine epinephrine which is last in the cascade did not increase. In fact it went down a little. So my urine neurotransmitter experiment is consistent with what Melchangi is saying here. That even when norepinephrine increases (and in my case when dopamine increases) my epinephrine does not increase.
Also when my urinary dopamine and norepinephrine increased I fell into PFS onset level insomnia and stayed up for 8 days and lost 8 pounds of lean muscle and I’m 10 years into PFS. Why ? Why did I feel like I had too much adrenaline (epinephrine) when it did not even increase according to my urine test . So like others are saying here maybe the issue is too much norepinephrine or maybe it’s something at epinephrine receptor level that went “out of wack” when Allopregnanolone was inhibited temporarily while inhibiting 5AR. The point is this is not the only evidence of neurotransmitters imbalance I am seeing in my self. I’m seeing evidence of GABA and Glutamate receptor imbalance as well
Now one way to experiment is to try to increase epinephrine by taking cofactor SAMe. Another option is to go to the very beginning of the epinephrine cascade and take phenylalanine, tyrosine and DOPA and see what happened’s…I posted the cascade above so everyone can see what I mean
We should come up with a list of optional experiments based on this information and if volunteers want to trial the ideas then awesome
SAMe (2)|451x499](upload://dXcFk7jZezMMvhH2H7TPF80IJ72.png) increases) epinephrine at the end of the cascade does not…