So, what’s that mean for us, for the dumb ones in the room? Haha
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(Yes, sorry, I also have the brainfog and would like dumb-person hand-holding.)
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Methyl Steroid is a Glucocorticoid and obviously there is a direct link with 5α-Reductase Type 2, this is what it mean.
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Another link study Glucocorticoid and Androgen Activation
Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1*
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Variable expression of 5-alpha reductase 2 in the aging adult prostate is regulated by DNA methylation
Induction of inflammation with lipopolysaccharide (LPS) stimulated the TNFR1/NF-κB/IL-6/DNMT1 pathway, leading to hypermethylation of the SRD5A2 promoter and silencing of SRD5A2, while treatment with both LPS and TNF-alpha inhibitor reversed this pathway and reactivated SRD5A2.
http://cancerres.aacrjournals.org/content/75/15_Supplement/1052.short
Interestingly Methylprednisolone is a Glucocorticoid and it is also a potent LPS and TNF-alpha inhibitor+ also able to cross BBB.
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It is possible that high dosage of Methylprednisolone changed adrogens receptors expression and make them to work properly.
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Interaction of the Glucocorticoid and Androgen Receptors in Adipogenesis
https://www.sciencedirect.com/science/article/pii/S1074552112003328
What I am trying to show here is that Glucocorticoid and Androgen Receptor are very correlated in fat there are affinity of AR to Glucocorticoid hormone.
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Moonchild, with all due respect, your incessant posting of theories one after the next does little to bring us closer to answering the mystery of PFS. What it does do is demonstrate an understandable angst to ‘solve this once and for all.’
This is a complex problem and you, with your limited understanding of the issue in all likelihood won’t solve it. I would rather devote your effort to competing the survey and carefully thinking about what you will post instead of being the loud forum member who appears in almost every thread with a new theory, or bleats the same tried and tested notions again and again and again.
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I improved all my simtoms while on them.
How do you explain that anonymous get well CURED ?
Do you want to wait until the survey is done , by the way I did it, and then wait for somebody get interested and start another study that can easily can take another 10 years just to find out maybe was going on ?
Another 10 years to find the direct way to fix it maybe.?
Or you want to try a approach that possible indirectly or by accident can fix the issue like Anonymous for example.?
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Are you using glucorticoids ? What dosage? Pill ? For how long have you using it ?
How do you get a doctor to prescribe ?
Thank you for pointing
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Listen, if you want to use your body as a lab ‘guinea pig’ nobody will stop you. That’s your choice and yours alone. Many have lost their life through adopting this approach. It’s like Russian roulette, except there’s more than a one in six chance of getting the bullet.
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Good point! If there is even slight chance to get worse using glucocorticoids, it is simply not worth it! Could have helped some people but if others got fucked from it, it is just not worth it. It is like if you tell a healthy person to take Fin, because the majority of people are not getting sides 
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Hello!
I tried Methyldprednisone with tablets, I took something like 1-2-4mg (3 days). At the 3rd day I became ill because a stomach virus… then at the 4th day I notice a very low adrenal function… 5 days later im normal. Not change in symptoms so far.
Your case is very important for the whole community, it deserves to be thoroughly analyzed.
You were totally impotent and then you were cured, please tell your doctor that if he finds the solution, he can become a new billionaire with a commemorative statue and a glory page on wikipedia.
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Did you recover voice man? I too have loss of projection. Like larynx fatigue.
So why no one tries this possible treatment? Exactly like op did? Is it too hard to acsess to the drug?
Hi guys. Just wanted to chime in here. I’m not pfs tho, I’m pssd. But my symptoms are very similar to pfs damage. I have a lot of chronic fatigue muscle wasting bruising, weight gain in belly.
I’ve had pssd for 14 years. The only times my condition improved significantly has been after steroid injections. Oral steroids do not have the same effect. I definitely think there is something to this.
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Forunately for me I still hold my third world country passport and can do a hail mary combination of drugs - under supervision - cheap as dirt. I am willing to undergo any combo. Mind you that my condition is due to use of nandrolone ( Aka deca dick). Most juicers have claimed libido comes back over time but since ALL my hormones (except insulin) was hay wire for a prolonged period of time, I assume metabolism is very slow in my body. I have done almost 3 grams of testosterone as well as proviron, hcg, b6 - b12.
Next is lithium, igf, hgh and possibly methyl steroids.
I am open to hear from experienced users.
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Anyone tried or willing to try this stuff?