If you can get 100% erections while sleeping but not while being awake and aware of it, it is hard to believe that something like “cells” died inside your penis. How is it then possible to get nocturnal erections. I think a lot of issues with the penis are connected with the brain for some of us.
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Yeah that’s right, but how many of us have 100% nocturnal or morning erections? Must be a minority.
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True that. Imo if you have 100% erections with cialis there is not a big chance to have dead cells. Otherwise it wouldn’t be possible but who the hell knows. So keep the blood flowing with or without.
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These guys on YouTube know only two things about pfs…Jack and shit and Jack left town…
This guy and the Derrick bro science dummy have absolutely zero knowledge about this all they know is hormones…
Baylor has shown this is way past all that…
It is changes in gene expression which basically means end products are not being made correctly such as proteins which means cells are not functioning correctly anymore…
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the guy in the video does say that as well
You’re right I have to take this back a little he has clearly done more homework than the other dude…made several good and valid points not the same old low testosterone dude bro science junk.
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The problem with these guys is that they consistently mischaracterise what PFS is, when currently, no-one knows. They also then leap to potential treatments, which is ludicrous. It’s just pin the tail on the rare disease donkey.
While he does address gene expression as a cause, he demonstrates a very basic grasp of the concept and then just moves on to talking about Wellbutrin and finasteride. Anyone could take 10 minutes to watch an Amoeba Sisters video on YouTube or just read one page of Wikipedia about epigenetics and make the exact same observations he did.
The other problem with these guys is that they distract from real research into the problem. By appearing knowledgeable and recommending potential treatments, many of which have been tried before, it distracts the community and provides false hope. The patient record captured here on propeciahelp over 15 years clearly demonstrates that treatments are in the majority of cases ineffective, unrepeatable or provide extremely sporadic belief. I hate to break it to Derek, but if he knew a thing about epigenetics, he’d know that gene expression cannot be reversed with Wellbutrin.
I know they think they’re doing us a service, but frankly, they’re not.
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not trying to argue here because i kind of agree with you
just want to clarify what i got from the video
he doesnt say welbuterin reverses epigenetic changes, just that while taking fin, welbuterin helped people reverse brain fog. but not after getting PFS, only before PFS. he says maybe hdac inhibitors might be able to help with PFS, and tbh that’s what axo and awor and others have speculated before.
agree that its all speculation and whatnot, but i disagree that its not helpful. we have very little awareness and guys that admit its real.
this is a type of compromise we have to make and appreciate that there are guys even admitting that PFS is real. on top of that he mentions that its epigenetic related.
id say thats a win for us currently
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No, there’s a big difference between this kind of awareness, and good awareness that accounts for the symptomatology of the disease, a considered view of current scientific findings, and real patient experiences.
Someone acknowledging the problem while also having a poor grasp of it is just as damaging as someone who dismisses it.
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This is also inaccurate.
i have to disagree here. the average person cannot grasp all the scientific details. if you mean create awareness among the medical community then i agree getting the technical stuff right is correct.
but when it comes to the average joe, it makes almost zero practical difference. the simpler the better almost always.
and to your point on awor and axo’s speculation on hdac inhibitors, i clearly remember a post started by awor making a list of hdac inhibitors.
No, it really does make a difference. Because again, mischaracterising the disease creates a culture where it’s ok to continually do that in the absence of research, which is one of our biggest challenges. It’s like someone creating a video about cancer and saying “cancer is caused by walnuts and can potentially be treated with pixie dust”. That’s just nonsense and serves no purpose for real progress on the issue. We’ve had “awareness” for 15 years, and it currently amounts to:
- PFS may or may not exist
- Quite often it’s an article about “man gets ED from hair loss pill”
That has not moved the needle one bit on this issue for 15 years. Doing things for the sake of doing them does not mean they are of quality.
And you’re right, awor and axo did make a list of HDAC inhibitors as substances that could potentially have an effect on symptoms. They did not say it would be a positive effect, as evidenced by two patients recent experiences with sodium butyrate. So again, your statement is inaccurate.
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we’re going to have to agree to disagree on the awareness. you are speaking in ideal situations, but that doesn’t happen practically.
the guy in the video articulated the following:
- PFS is REAL
- its epigenetic
a couple of bad points after wards does not erase what he just did for us. no one watches the video, thinks “oh my god PFS is real”, and then thinks “wellbuterin? HDAC inhibitors? man this guy is full of shit about PFS being real”
no, in fact his audience is now aware that it is in fact real, when they previously were not…
as for the awor and hdac topic, i used the term “speculate” above when comparing them to the guy in the video with his speculation.
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I agree with this.
When i heard permanent epigenetic changes such as cell death in the penis i was a bit skeptical. Maybe im biased because that is literally the worst case scenario and i was pretty saddened to hear that from Leo especially since i follow him alot
BUT if one is able to get normal nocturnal and morning erections… its hard to imagine that ED side effects are “permenant”.
An insane world when a random YouTuber can tell us more about the syndrome than the majority of doctors.
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I was taking Wellbutrin as well, and continued to take it for almost a year and a half after PFS.
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Hey to all the guys in this discussion:
All the Videos from hairloss, bodybuilding supplement freaks (and randoms like @Papasmurf described) are like to much AR in the target tissues and you are oversignaled an there is no adequate reaction more in the target cell.
Like @Sugarhouse said getting awareness to our disease, we need the victims to be seen on videos, we need serious doctors and scientist videos and TV reportages. And not the creazy freaks mixture on videos, because for this our lives are damaged to much. I think even a pietatfull video to the 89 +++ unknown suicide victims would give the awareness we need.
PFS is a horror disease wich destroyed so many lives, including my own
!!!as accepted pharma collateral damages!!!
But so many sufferers need theory’s and the hope for supplements efforts to survive.
And now it’s ten a clock and I try to stand up
Whats baffling to me is that leo himself takes finasteride daily not even for hairloss, but just so that in the future he won’t get BPH. He doesn’t even know if he will and bph may come in decades time. I dont understand. He even acknowledges pfs as a condition and yet takes fin for that stupid reason.
Have you seen any benefits? If you are no longer taking it, what made you quit?
Wow. I think if he truly acknowledged the potential multi-systemic nature of the disease, and how thoroughly devastating it can be, he wouldn’t go near any 5ARI. The fact that he acknowledges PFS and therefore is providing informed consent to the potential risks of developing it, because he doesn’t want to develop BPH, is baffling.
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