Interesting video about PFS by Leo and Longevity. Don’t know if he’s got it right but at least he has the decency to acknowledge it’s real.
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So anyone used HDAC inhibitors before? 
Interesting how he said that people have success avoiding side effects by combining Wellbutrin and Finasteride… That’s just not true.
That’s exactly what I was doing when I got PFS. I was taking 450mg of Wellbutrin and 1 mg of Finasteride daily.
So no, Wellbutrin will NOT save you from the side effects. I’m the living example of this.
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So basically he says the mental sides can be fixed but the sexual sides are permanent which seems to be the case for most of us here. I know the brain fog for me has gotten significantly better to where I can drive and function okay but I’m plagued with loss of muscle fatigued some days and have no sex drive and extremely poor erection quality.
Does anyone know how much it would cost to have a study that looks into cell death in the penis tissue for PFS? If it shows we have cell death in the corpus cavernosum then maybe this would at least explain why the sexual sides are permanent.
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If we had ‚cell death‘ in our penises it wouldn’t be possible to have nocturnal or morning erectiions right?
That’s what I’m getting at so yes. I can’t believe the Baylor study couldn’t rule this out it’s so disappointing. Also for each person it may vary some here can still have okay or decent erections just lack of libido ect. but in severe cases like mine nothing works and my guess is that once cell death occurs the tissues will not respond to androgen treatment which is why when I used TRT it did nothing for restoring the penis tissue or have any benefit sexually.
Isn’t it the other way around though? That the lack of erections and blood flow causes atrophy and that we can prevent it by artificially allowing as much blood as possible?
I woke up the other morning about 4:30am with a solid pre PFS boner ……
Then the following evening was back to being soft erections / flaccid.
The fact that I had that solid boner proves that the possibility is still there, a big part of this must be a fault in the signalling
Knowing that the possibility of having a solid erection is now there brings great hope
Btw I used Wellbutrin alongside finasteride also for two stints. By the time of the second stint I already had erectile dysfunction, it definitely helped with sexual side effects , but I don’t remember it being a 100% cure or prevention or anything like that.
I have not used Wellbutrin post finasteride discontinuation…
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It would, it’s not like 100% of the cells die.
As he said it could lead to stuff like narrower penis, peyronie’s or venous leaks. The study on rats he’s talking about also showed how cialis concurrently with fin could mitigate the loss of eNOS etc.
But there’s no telling if it could help “when the damage is done”.
If you can get 100% erections while sleeping but not while being awake and aware of it, it is hard to believe that something like “cells” died inside your penis. How is it then possible to get nocturnal erections. I think a lot of issues with the penis are connected with the brain for some of us.
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Yeah that’s right, but how many of us have 100% nocturnal or morning erections? Must be a minority.
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True that. Imo if you have 100% erections with cialis there is not a big chance to have dead cells. Otherwise it wouldn’t be possible but who the hell knows. So keep the blood flowing with or without.
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These guys on YouTube know only two things about pfs…Jack and shit and Jack left town…
This guy and the Derrick bro science dummy have absolutely zero knowledge about this all they know is hormones…
Baylor has shown this is way past all that…
It is changes in gene expression which basically means end products are not being made correctly such as proteins which means cells are not functioning correctly anymore…
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the guy in the video does say that as well
You’re right I have to take this back a little he has clearly done more homework than the other dude…made several good and valid points not the same old low testosterone dude bro science junk.
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The problem with these guys is that they consistently mischaracterise what PFS is, when currently, no-one knows. They also then leap to potential treatments, which is ludicrous. It’s just pin the tail on the rare disease donkey.
While he does address gene expression as a cause, he demonstrates a very basic grasp of the concept and then just moves on to talking about Wellbutrin and finasteride. Anyone could take 10 minutes to watch an Amoeba Sisters video on YouTube or just read one page of Wikipedia about epigenetics and make the exact same observations he did.
The other problem with these guys is that they distract from real research into the problem. By appearing knowledgeable and recommending potential treatments, many of which have been tried before, it distracts the community and provides false hope. The patient record captured here on propeciahelp over 15 years clearly demonstrates that treatments are in the majority of cases ineffective, unrepeatable or provide extremely sporadic belief. I hate to break it to Derek, but if he knew a thing about epigenetics, he’d know that gene expression cannot be reversed with Wellbutrin.
I know they think they’re doing us a service, but frankly, they’re not.
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not trying to argue here because i kind of agree with you
just want to clarify what i got from the video
he doesnt say welbuterin reverses epigenetic changes, just that while taking fin, welbuterin helped people reverse brain fog. but not after getting PFS, only before PFS. he says maybe hdac inhibitors might be able to help with PFS, and tbh that’s what axo and awor and others have speculated before.
agree that its all speculation and whatnot, but i disagree that its not helpful. we have very little awareness and guys that admit its real.
this is a type of compromise we have to make and appreciate that there are guys even admitting that PFS is real. on top of that he mentions that its epigenetic related.
id say thats a win for us currently
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No, there’s a big difference between this kind of awareness, and good awareness that accounts for the symptomatology of the disease, a considered view of current scientific findings, and real patient experiences.
Someone acknowledging the problem while also having a poor grasp of it is just as damaging as someone who dismisses it.
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This is also inaccurate.