Joint pain

What are the possible causes of joint pain?
I’ve heard low estrogen can cause it, but my gyno has just barely stopped (if at all) so i’m sure that’s not the case for me. Any ideas? Thanks.

having low estrogent does not mean you will not have gyno. if your T/E ratio is s*up you will. there are many fin users whose E2 is below normal range, I my self has very low estrogen yet we are having gyno. there is also a debate that blood hormon levels are different from urine hormone levels.

Okay so you can have it if both test and estrogen are low. But if test is high and estrogen low you cannot have gyno right? (Assuming the androgen receptors are taking in the testosterone) Actually it would make sense that both my estrogen and testosterone are low.

The only thing that brought me some relief in this area has been bioidentical DHEA.

What is that? And to what extent did it help?

It’s a hormone… Now, I have knee pain only if I bend all the way down; before DHEA, my knees would hurt all the time.

I don’t have joint pain, But my joints pop a whole lot. They never use to pop like this before propecia. My neck, shoulders, arms everything just pops all the time.

Mine too.

I did a quick search and read that some had this Jaw clicking thing. Well I have it to, I open my mouth halfway then CLICK. Most of my joints click too and I have serious joint pain and muscle wastage. Has anyone had a clear answer for their docs about this? Im fuckin goin to my GP on monday. This could be fucking Osteoarthritis.

Joint pain can be caused by hyperuricemia – too much uric acid in the blood, due to a genetic disorder or kidney problems (kidneys normally filter and excrete the uric acid)… the thing is, there is no history of this (or any sort of kidney problems) in my family, and yet I have been having many joint problems for years, ever since I started fin – I got bursitis in my knee when running, had weak/stiff ankles, and now I have a lump in one of my finger knuckle joints. It is stiff and swollen.

Suddenly, I have been having sharp pains at the base of my big toe and I realize – I think I have gout.

Gout is a form of arthritis caused by too much uric acid buildup, which causes crystals to form in joints (like the node on my finger) and flareups/inflammation to occur.

Have any of you had your uric acid levels or other kidney blood work checked?

Hi guru20

I’ve developed what I suspect is gout in recent weeks. I’ve had the classic symptoms, but the blood test was negative.


That should provide conclusive evidence that you are ok?

Not quite sure of your point, Mew. Obviously the blood test might have produced a false negative, but whether or not I have gout (or something similar) and whether or not gout could be part of the PFS jigsaw remain moot.



Also, the blood test all depends…

if you are testing kidney function problems, I think the blood tests should pick up any major kidney issues (kidney disease), even better than the liver function tests do.

However, if you are testing uric acid levels, those are constantly changing. You could suffer from hyperuricemia and yet have completely different pH / acid readings depending on when you do the blood test and what you have consumed.

I’ve noticed that after I sleep and wake up in the morning, I usually feel okay. But by the end of the day I feel awful, and I often wake up in the middle of the night dehydrated, needing to urinate, and/or with shooting pain in my foot. Other than gout, I really don’t know what would cause these symptoms… (I’m going to the doctor tomorrow morning)

My joint pain has gotten considerably worse over the past year. I first started having pain in my left hip joint a year ago, which was 1.5 years after I had gotten PFS. Now, a year later, I have pain in most joints of the body - hips, knees, shoulders, fingers, feet, heels, elbows… My mobility is compromised and not only can’t I do any exercise but also I have to limit my daily activities. Sitting on hard surfaces is painful too.

Is anyone aware of the mechanisms through which PFS may cause joint pain? Alternatively, what are some possible causes of joint pain that may be consistent with PFS? Also, how is joint pain explained in other chronic conditions such as post-menopause or low testosterone and is the effect established scientifically?

I can think of two possible reasons. One is that a change in androgen levels or androgen sensitivity leads to atrophic changes in ligaments in the bursae that hold joints together. Another is through kidney damage from finasteride, about which there was a paper recently, and subsequent accumulation of uric acid crystals in joints.

Has anyone recovered from extensive, late-onset, PFS-related joint pain?

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Hey Sibelio,

I actually recovered from joint and muscle pains that began after starting Accutane in 1998, but the recovery didn’t begin to occur until 2013-2014. Just saying it is possible.

Can’t offer my “treatment protocol” because it was more or less a spontaneous recovery.

All I can think of is improving my diet to include more vegetables beginning in 2010 and regular exercise from 2013-present somehow helped. Who knows.


“That said, scientific studies conducted in recent years seem to indicate a much more significant and direct correlation between testosterone and joint pain. These examinations revealed critical findings, such as the fact that testosterone stimulates the production of substances known as chondrocytes (which are said to play an important role in cartilage repair); could, in some cases, completely reverse degenerative cartilage problems and reduce chronic back pain when injected in therapeutic dosages.”

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"In this study, Swedish researchers analyzed blood samples collected from 104 men who were later diagnosed with rheumatoid arthritis and 174 men of the same age who did not develop the disease. The average time between collection of the blood sample and a diagnosis of rheumatoid arthritis was just less than 13 years, but ranged from 1 to 28 years.

After taking into account known rheumatoid arthritis risk factors such as smoking and weight, the researchers found that men with lower testosterone levels were more likely to develop rheumatoid arthritis. They did not, however, prove a cause-and-effect link between the two.

These men also had significantly higher levels of follicle stimulating hormone – a chemical involved in sexual maturity and reproduction – before they were diagnosed with rheumatoid arthritis, according to the study, which was published online April 3 in the journal Annals of the Rheumatic Diseases .

The findings suggest that hormonal changes occur before rheumatoid arthritis develops and could influence disease severity, the researchers said in a journal news release.

Rheumatoid arthritis results from the immune system attacking the body’s own tissues. Previous research suggests that testosterone may dampen the immune system, the researchers said."


Does anyone else have extreme joint pain? Right now I can barely leave the couch, let alone the house. My hip joints seem to be severely inflamed as I feel sharp pain with every movement. How much worse is this going to get?!

Has anyone with severe and persistent joint pain seen any doctors for it or run any tests such as MRI or x-ray or blood tests?

I recently had a rheumatoid arthritis panel done and had my rheumatoid factor IgG elevated. It might have been a temporary thing because I had been sick recently. Might have to repeat it. I haven’t been to a doctor yet.

Rheumatoid factor IgA – <0.1 U/ml (Up to 20.0)
Rheumatoid factor IgM – <0.1 U/ml (Up to 20.0)
Rheumatoid factor IgG – 29.8 U/ml (Up to 20.0) ELEVATED
anti CCP – 11.9 U/ml (Up to 20.0)
anti MCV – 4.5 U/ml (Up to 20.0)