So are you telling me that the fact that my plasma 3b-diol is low and my urine allopregnenolone is high is not important?
Before assuming you are right consider this:
3b-diol is a potent estrogen receptor beta agonist. I get worse when I inhibit estrogen. I get better when I increase estrogen. Even though you are correct that my plasma 3b-diol levels are probably not going to match up with my 3b-diol CNS levels. But that does not mean my plasma 3b-diol levels are not important. Low plasma 3b-diol levels tells me that my 3b-HSD enzyme is converting low amounts of DHT into 3b-diol. Otherwise I would have higher amounts of 3b-diol in my blood if my 3b-HSD enzyme was converting higher amounts of DHT into 3b-diol. So low plasma 3b-diol levels is giving me a clue as to the status of my 3b-HSD activity.
Here is another example:
I don’t know my CNS allopregnenolone levels. But I do know that melcangi’s PFS study found low allopregnenolone in the CNS of the PFS group. I also know that my urine allopregnenolone is high. So based on this information I can make an educated guess that maybe allopregnenolone is low in my CNS as well because I’m getting rid of high amounts of Allopregnenolone in my urine which is excretory.
Maybe my body is excreting high amounts of allopregnenolone because it needs to get rid of it for a reason possibly pointing to an issue with the GABAa receptors in the brain. Because allopregnenolone in the CNS is a positive allosteric modulator of the GABAa receptor. So If there is too much action on the GABAa receptors body may be peeing out as much Allopregnenolone as possible so that the allopregnenolone does not make it to the GABAa receptors. Additionally my plasma
3a-diol is low and my urine 3a-diol is high. My DHT is not even converting to 3a-diol in high amounts in spite of my body peeing out high amounts of 3a-diol. This tells me that my body also wants to get rid of high amounts of 3a-diol which is also a potent GABAa receptor positive
allosteric modulator.
My point is that you are thinking one dimensionally and can’t make the same educated guesses I can because you don’t know your urine allopregnenolone levels or your blood 3a-diol or 3b-diol levels. I understand that you read somewhere else on this forum “that only CNS levels are relevant” but someone else posted that who also thinks one dimensionally. I’m working on that 4th dimensional level thinking. Humans will likely never see the 4th dimension but I’m certainly not going backwards…
Anyway back to Joe’s protocol