I posted this elsewhere but I hope it helps those poor souls with very low estrogen syndrome:
"I’ve normal Testosterone level but very low E2. I think fixing the gut will raise E2 because I did so much research on factors that affect E2 level in the body. The factors are:
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Low Testosterone. This isn’t the case for many men and it wasn’t my case either.
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Aromatase enzyme deficiency. This could be genetic and also when using Aromatase Inhibitors. I did several AIs and some made my E2 literally ZERO and libido non-existent. But I returned to normal after sometime, fortunately.
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Low DHEA-s. This is my case (low DHEA-s) because taking 25mg DHEA for two weeks increased my E2 from 11 pg/ml to 28 pg/ml. Check DHEA-s level.
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Anti-estrogen supplements/foods. I made a full list of them. They include high dose zinc, fat soluble vitamins A D E K, green tea extracts, high olive oil consumption, melatonin, high B1 & B2 vitamins, etc.
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High fiber diet. Too much fiber binds to E2 in the gut and is excreted from the body with stools.
& MOST IMPORTANT FACTOR THAT I DISCOVERED…
- Low gut bacteria that recycles deactivated E2 back into blood stream. There’s a group of bacteria called Estrolbolome.
" The estrobolome is a collection of bacteria in the gut which is capable of metabolising and modulating the body’s circulating estrogen. It is the bacteria in the gut, and the estrobolome , that affects estrogen levels, which in turn can impact weight, libido and mood."
This bacteria make an enzyme called Beta-glucuronidase which deconjugates E2 in the gut. There are scientific citations (I can share them) stating that the most important memeber of this bacterial group is E. Coli (yep there’s a friendly E. Coli too). I suspect you have severe gut dysbiosis and thus very low Beta-glucuronidase activity.