Is Neurotransmitter therapy the key to recovery?

Therapeutic Efforts Pharmaceutical
#41

i am interested in your results as well joetz

i am on TRT and no matter how much i come into range with e2 i still don’t get good wood and a lot of precum and PE

in the meanwhile i tried proviron, no results, so dht is not my issue

i tried HGH now a couple shots at 1 iu still no results, except stiff arms can barely move them

and what did work for me is usp labs powerfull which is mucuna/l-dopa

i standard take 5-htp 50 mg at night for better sleep

sexual function returned for me when i treated adrenal fatigue with hydrocortisone but still had PE, now on TRT with HC still PE

i am thinking of giving powerfull another try, but balance it with extra 5-htp… for the precum i might look into an anti inflammatory herb, im gonna try turmeric

no more precum and increase in dopamine while staying balanced should probably do the trick

otherwise it’s cialis for the rest of my life

good luck and keep me posted

here a link from another guy who had success with such therapy:
forum.mesomorphosis.com/mens-health-forum/so-you-think-your-134252051-2.html

1 Like
#42

I’ve been thinking why doxy has been helping me a little. The answer to our problems is either to do with hormones or neurotransmitters. Some people do respond to hormones. I have noticed over the years the idea of tyrosine has persisted also. As tyrosine is a precursor to the thyroid i am unsure whether it is this link that is relevant…or whether it is do more with the brain.

Maybe this has something with why doxy helps me a bit:

ncbi.nlm.nih.gov/pubmed/16919849

#43

cumwakka,

Your on the right track…Low serotonin is usually a result of Pre Ejac., or low Noephrinine. There is definitely a neutrotransmitter imbalance…

#44

I read Tommy6565’s story and it really inspired me. He was cured for an entire year on Tyrosine and that’s one of the pills we are playing with. I have gotten really really close to a full recovery so many times, but not the full long term recovery Tommy had. I will get there though, it’s just a matter of making the right adjustment. I tell the doctor that the “lights flickered”, meaning that I had a moment where everything was right. It happened several times so far and each time i feel the lights flicker, my mind sharpens like a razor, fog lifts and I start speaking like I have a limitless vocabulary and ability to express myself. Also, during those periods, full sexual function returns. If I ever get dialed in where I am at the sweet spot and stay there, I’m done, I’m going to live life to the fullest as a fully recovered person.

I did the urine test on tuesday, I am hoping to have the results by Thurday and do another adjustment. I can’t wait, for the first time in a long time I feel like I really have something to look forward to.

#45

Man, I hope you get there. I’ve been there a number of times but couldn’t hold on…

#46

Joetz,I hope you find the right combination and everything resolves for you because I know how it is to feel a slight recovery,which always ends up being shortlived.

#47

Ok folks
New formula based on the last urine test

Lets see how it works out. I just started today.

#48

Good luck mate.

#49

Has anyone every tried antipsychotic meds as a solution? They are known to upregulate dopamine receptor activity.

As has been noted, taking tyrosine/phenylalanine has produced positive, short-term results. Yet, supplementing these dopamine precursors is not causing our bodies to produce more dopamine in the long-run, nor increase the function of our dopamine receptors. Quite possibly, wouldn’t increasing the amount of dopamine in our bodies via supplementation downregulate our our dopamine receptors or natural dopamine production, as the increase in dopamine is not coming from some sort of rewarding activity? However, with some antipsychotic medications, the dopamine receptors stay at a level of increased activity. Not saying this is a cure, but just curious if anyone has tried something like this.

Conversely, other obtainable (yet sometimes illicit) drugs (alcohol, heroine, cocain) have been shown to alter the number/activity of dopamine receptors. I’m pondering whether either increasing or decreasing our dopamine receptors/dopamine receptor activity would result in a change in our symptoms, while allowing our bodies to maintain their current dopamine production levels?

Wow, how f*** up would that be if cocaine abuse solved our problems? Actually, probably no more f*** up than our current situations.

TC,

Former

#50

In my previous post I forgot to mention that “Dopamine receptors are typically stable, however sharp (and sometimes prolonged) increases or decreases in dopamine levels (via stimulants or antipsychotics mainly) can downregulate (reduce the numbers of) or upregulate (increase the numbers of) dopamine receptors.” However, if such is the case, that could potentially explain why some people experience long-lasting side effects immediately, and some don’t get long-term side effects until years later.

Granted, my quoted sentence is from Wikipedia, but you can look at each of the papers this information is cited from on Wiki or find similar information from other journals online.

Best -

Former

#51

Dopamine is tied into sexual desire while norepinephrine is related to subjective excitement.

Dopamine is key in orgasms.

High serotonin is bad for your sexual response. Hence SSRIs cause dysfunction.

#52

Serotonin prevents premature ejaculation…Too much of it isn’t good and will give you ED. A balance is important…

#53

Former…just to give you a bit of feedback on your questions about Dopamine.I have experimented with amphetamine and noticed a surge in libido which lasted about 18 hours.Now I would not recommend this to anyone as the recovery period is not worth the “high”,not to mention that this stuff is illegal as well.I am curently trying Wellbutrin XL 150mg/day and do notice a slight boost in sexual appetite.

#54

Whalen -

I have an appointment with a neurologist in 2 weeks and am debating whether or not I should attempt to get Wellbutrin. I recently made a post about a theory regarding dopamine receptors (viewtopic.php?f=23&t=4481), which makes me leery of trying Wellbutrin. Unfortunately, my brain fog is so bad that I think I may lost my job, so I may have to try some extreme stuff.

Are you still having brain fog? Or did you not have it at all?

#55

Former…actually I was lucky enough to have never experienced brain fog on a regular basis.Sure,I have days where I’m feeling “out of it”,but that might be due to personal reasons or a lack of sleep etc.Wellbutrin is no miracle cure…in fact I stopped it for a few days and noticed no difference in mood or libido etc.Even when I have a boost in libido,I’m still fully impotent unless I use a Viagra.Fin ruined me…

#56

I’m afraid I’m going to have to put this treatment on the backburner for a few months. I developed a health problem that is very serious and until I get it resolved I’m not going to be able to pursue the neurotransmitter therapy. Maybe in three months or so I can go back to trying to get my neurotransmitters working right again.

I know a lot of people are anxiously following this thread to see what happens next and I am sorry about the delay. Sometimes things happen that are beyond your control

#57

Good luck buddy!We are all wishing you well!

#58

Here is a very useful thread on mind and muscel covering many dopamine meds:

mindandmuscle.net/forum/index.php?showtopic=42580

Check it out!

#59

I think I may be on the verge of a breakthrough guys

I am of the opinion that this sickness is 100% caused by a problem with neurotransmitters. I was taking pills to help me and I hit the sweet spot for 3-4 days and was 100% recovered during this time. Unfortunately, like many fixes, it was unsustainable. After that point I spend a lot of time money, energy, etc, seeing a neurotransmitter doctor and he was not able to get me back at that point again. I finally gave up.

But the fact that I had a full recovery proved to me that I was on the right track. I decided to pursue the same strategy and I got myself an alpha stim scs

It works my using electrical current to help balance out neurotransmitters and can help get rid of depression without the nasty side effects of SSRIs.

I am noticing now after 2 and 1/2 weeks some very big changes. It started off small. Better sleep, better thinking, less brain fog, then a little emotions here and there. Then I noticed libido bouncing back a bit for an hour a week and then an hour every day. This week, since monday has been amazing.

I’m not quite ready to declare myself cured for a few reasons:

#1 I have a long way to go until full recovery
#2 I have thought I was cured before only to have things come crashing down like a house of cards
#3 I am taking other supplements and can’t really determine what is working for me and what isn’t.

I’m going to start weaning off the supplements and see if the progress continues. So far things are very encouraging.

#60

Joetz, that is great news! Keep us posted.