We all know this theory, but i want to write this again. I have talked with a guy who is currently fixing himself and many people. Regarding forum rules, i hope im not breaching any of it, read the forum guidelines before reading my message.
PFS: Upregulated AR’s and lack of neurosteroids. Studies confirmed this. Solution: Exegenous Androgens and HCG. Why: Any exegenous androgen supplementation will DOWNREGULATE the AR’s. And HCG will adress the neurosteroid issues, as we also know, especially from JoeKool’s case.
That’s why Moonman (partly) and @Ifoundacure recovered. Some cases here try mild- normal doses of androgens and give up. But they might have needed something stronger, like Trestolone to fully fix the AR issue. That’s it, very simple.
Let’s move on.
PAS: Downregulated AR’S.
https://pubmed.ncbi.nlm.nih.gov/7714084/#:~:text=The%20decrease%20in%20skin%20androgen,in%20the%20pathogenesis%20of%20acne.
https://www.sciencedirect.com/science/article/abs/pii/S0003277815000064#:~:text=Androgen%20receptors%20on%20keratinocytes%20and,and%20the%20production%20of%20sebum.&text=It%20is%20also%20suggested%20that,controls%20of%20the%20same%20age.
How to fix this. Kudos to Joe Palmer: Progesterone injections 50mg- subQ before bed daily. and HDAC inhibitors (Sodium Butyrate, NAC, Lithium Orotate.) to fix methylation issues and speed up the healing process+ ALA and L- Carnitine for more AR upregulation.
Alternative method for PAS: A guy named Olive, who supposed to be a doctor in U.S and currently treating PFS cases, suggested on raypeat- forum that L- Carnitine injections daily, i don’t remember the dosage right now, should fix PAS by upregulating the AR’s on the affected tissues. The dose was not huge, i will edit if i find the post again.
This is a weird day for me, i was sure to start TRT few hours ago but after talking with some people, my mind is changing, i think im going to try this theory first before TRT and Trest.
Because from my prior experiences too, my problem seems to be Downregulated AR’s… That’s why Proviron didn’t change a damn thing on me whereas it improved some PFS cases.
Now, i think we need more PAS cases to test this Progesterone theory. Im fed up with all of this, and will try it myself then.