I wouldn’t say I have massive fatigue. I have way less energy than before. If I exercise then there is a good chance that I am way drained the next day. I’m way weaker than before.
I guess saying “I am always drained” is a lot more accurate for me than saying “I have chronic fatigue”.
At the same time though, neurological issues is an issue; brain fog, memory, etc.
If you look at the guidelines for what is CFS or ME, Fatigue is the highest indicator at 95%, but nuerological issues is also up there.
LabCorp
Not sure. Get a few more pathogen tests done and then start a treatment plan. Most likely anti-virals.
AIDS patients actually respond to Androgens. That’s the big issue here. I do believe that activation of the androgen receptor is a competent of the innate immune response. So who knows.
At the same time though, pathogens (especially EBV and CMV) can cause androgen resistance through the following mechanism…
[i]The molecular mechanisms by which the Th1 pathogens are able to disable the body’s hormonal pathways are very clear. As patients accumulate a Th1 bacterial load, substances created by the pathogens begin to block the Vitamin D Receptor, slowing the innate immune response.
When the VDR is block by pathogens substances or 25-D it can no longer transcribe an enzyme (CYP24A1) that is supposed to keep the body’s level of 1,25-D in the correct range. At the same time, the cytokines released by the Th1 pathogens over-activate an enzyme called CYP27B1. CYP27B1 controls the amount of 25-D converted into 1,25-D. When the enzyme is produced in greater quantities, more 25-D is converted to 1,25-D. Both processes described above cause 1,25-D to become elevated in patients with chronic disease.
Unfortunately, when 1,25-D reaches a high enough level it is able to bind the body’s other nuclear receptors. The nuclear receptors are essentially the receptors that control the body’s hormonal pathways – the alpha/beta thyroid receptors, the androgen receptor, the progesterone receptor, the estrogen receptor etc. In his latest BioEassy paper, Dr. Marshall gives the exact affinities of 1,25-D for many of the nuclear receptors and shows that at high levels it is able to bind them quite easily.
When 1,25-D binds these receptors, it displaces the metabolites that are meant to be in the receptors under normal conditions, metabolites that allow the hormonal pathways to run correctly. So when 1,25-D displaces these metabolites the patient experiences hormonal havoc. Essentially every hormonal pathways is affected, especially in people who are very sick.[/i]
mpkb.org/home/pathogenesis/vitamind/metabolism
