Align (1Billion CFU) was the one. I used it for about 3 weeks. I’d like to assume that I didn’t suffer pelvic inflammation except for the occasional soreness in pelvic muscle/joints but this is probably due to heavy leg workout. My understanding is that Interleukin-8 (IL-8) induces neutrophil migration to sites of infection (or inflammation). Please correct me if I’m wrong.
That said, I mostly experience symptoms such as stuffy nose (probably from swollen turbinates.), headaches, and eczema/skin itchiness.
“Proinflammatory interleukins (IL-1β, IL-6, and IL-8) are elevated in patients with allergic rhinitis and have been shown to promote the activation of immune cells as well as to enhance expression of receptors for cell adhesion molecules (eg, selectins, integrins).19These events, along with IgE synthesis and eosinophil/basophil priming, collectively contribute to inflammation, venous engorgement, nasal hyperreactivity, and symptoms of allergic rhinitis, including congestion”
I’ve had several CBC labs done and Eosinophils count was elevated possibly indicating allergy. I wonder if Neutrophils count can be used as an indicator for IL-8 abnormalities. My high Eosinophils count (along with allergy symptoms) instigated after being on BioGaia L. Reuteri (histamine producing strain) alongside high consumption of beef liver (High Vitamin A content). It feels as if L. Reuteri was able to colonize my gut OR high Vitamin A (hypervitaminosis) was inducing increased immune reactions. I ate a lot of beef liver because I had high Vitamin D level, which I initially thought may have depleted liver retinol.
Both Vitamin D and Vitamin A appear to posses immunomodulatory properties.
Allergic reactions hit the adrenal hard resulting in Adrenal insufficiency. This is from AdrenalFatigue.org:
"Adrenal function plays an important role in allergic reactions. Most allergies involve the release of histamine and other pro-inflammatory substances (substances that produce inflammation). Cortisol, one of the primary hormones produced by the adrenal glands, is a strong anti-inflammatory (a substance that reduces inflammation). In fact, the amount of cortisol circulating in the blood is a key factor in controlling the level of inflammatory reactions in the body. For this reason, healthy adrenal function plays an important role in mediating the histamine release and inflammatory reactions that produce the symptoms experienced with allergies.
When the adrenals are fatigued, it is more difficult to produce the additional amounts of cortisol necessary to adequately counteract the inflammatory allergic reactions. People going through times of adrenal fatigue may notice that they seem to have more allergies or their allergies seem to get worse. Conversely, the more histamine released, the harder the adrenals have to work to produce enough cortisol the more fatigued they may become. It is therefore not surprising that people with food and environmental allergies commonly tend to experience adrenal fatigue as well. This can set up a vicious cycle of reduced cortisol allowing histamine to inflame the tissues more, leading to deepening adrenal fatigue as well as to bigger allergic reactions.
Actively supporting your adrenal glands and eliminating or reducing your exposure to foods and other substances that cause allergic or sensitivity reactions can help break this cycle as well as strengthen adrenal function. Food allergens can interfere with daily functioning and become a profound stress on your adrenals, so it is important to track down and eliminate these food sensitivities and allergies in order to both decrease your allergy load and promote adrenal health."
I’m aware that adrenal fatigue is not recognized by the scientific bodies but this goes perfectly in line with my n=1 case. Normalizing inflammatory cytokines based on your individual findings to restore adrenals is the way to go.
