Check this out… https://academic.oup.com/jcem/article/89/7/3313/2844310
Thank you @doomed80 I’m getting some tests done via a gastro so will see what that brings they organised an abdominal CT scan which I had last week. Waiting on a stool analysis, unsure what they’re testing and some bloods
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Brilliant! Nice find @surviveplz 
“Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFα, IL-1β, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10.”
I knew beforehand that Testosterone acts an anti-inflammatory because as I said I’ve experimented with testosterone + corticosteroid (both are anti-inflammatory) and had 100% recovery. I stopped Testosterone because it’s: 1. For life (i.e. commitment), 2. Testicular shutdown & 3. Fertility issues. Testosterone suppresses the immune system and this is a known effect.
However, exogenous testosterone doesn’t necessarily target the root cause of the problem since after stoppage, symptoms may resurface. My take now is to remove factors that are causing excess inflammation and gut dysbiosis is a major player here. Finesteride is said to cause dysbiosis probably through changing enzymes or hormones or other peculiar ways.
Need to find the source of inflammation. I read some of your earlier posts, regarding histamine, im currently trying to figure out if this is an issue in me and started taking ketitofen drops daily… im on carnivore also
Prosatitis, urine infection, eczama they are not coincidence.
I have also done some work for maybe executing FMT. It is looking very unlikely that here in Finland that can be done. So if any idead for a clinic, would be welcome 
You’re truly a fighter bro @Finfina Keep powering through and hopefully this year puts an end to this misery. There’re hot discussions on Reddit regarding FMT clinics. I was reading on this for a long while. Current clinics are mostly located in Sweden, U.K, Australia and I think Florida. Donor screening is crucial and it’s best to find someone who’s closely related and is living in the same household and share similar lifestyle/diet without history of antibiotics and other microbiome altering drugs. Opinions are divided on whether or not antibiotics/laxatives are necessary prerequisite to FMT success.
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Guys, do you think that testing:
IL-1beta , IL-6, IL-8, IL-10, IL-12, TNF-alfa
And:
TH1/TH2/TH17 balance,
Would be useful for us?
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It depends. In case of systemic inflammation of course you can detect some abnormalities in plasma. I have been tested for IL-6 in plasma, but the results was ok. I personally think most of us have a deal with some sort of neuroinflammation, especially those who have mental sides. In that case CSF testing for cytokines must be performed, and this is not a common thing. Nevertheless, the results of such a test will be invaluable.
Yes I think it would be useful to look at these markers or to check.
IL-10
IL-8
IL-12
It would be expensive out-of-pocket though unless you can get a Drs approval for possible insurance coverage.
Has anyone else apart from me experienced post-fin alopecia barbae or this dotted pattern on your palms that fluctuates randomly by any chance?
I had a stool test done by Genova Diagnostics and it showed my fecal secretory IgA (which measures inflammation) to be off the charts. Normal range is anything below 885 mcg/g and mine was 1,267 mcg/g. Also showed I had candida overgrowth. This was 5 years ago so hopefully it’s improving slowly cause I’ve been on carnivore for a year (was cheating with hot sauce until a few weeks ago though). Not sure if the gut / inflammation has anything to do with the root cause but it certainly doesn’t help that our immune system is over activated and attacking the gut.
Not the beard but the dots in the palm. looks realy strange sometimes i wonder what it is?
Did you get them checked?
Because of the extensive damage to one side of my face I had a dermal filler in what was to be the beginning of many treatments. Afterwards I noticed a fuller look across the collapsed upper brows and didn’t feel any adverse effects initially. . Later in the day I started to get very strong bone pain especially around the legs which isn’t unusual. I began to feel very fatigued, I’m normally wired. Then in the evening I started to get upper mandible pain which is a first for me, it was also sore to the touch. I slept better than normal maybe 5 hours in total but woke covered in sweat a few times. Today the 2 nd day I feel extremely weak even dryer than normal, can hardly see out of one eye and a general worsening in other areas. This all suggests to me that my immune system has reacted to the derma filler. I’ve had rheum since aged 14 and know how it feels when the immune system is attacking the body. Even though its targeting different areas of the body in convinced more than ever that Pfs is at least in part autoimmune.
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Excellent observation @LazarusRy
I too had dermal filler done twice this year to correct mild facial imbalances. The injector used hyaluronic acid based filler, which according to several studies is very bio-compatible. However, I’ve noted immune system reactions (excess inflammation) after each session. Symptoms included fatigue, irritability/depression, poor sleep, reduced libido, night sweats, joints pain, etc. I was actually searching around for first-hand experiences to confirm my suspicion.
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@doomed80 I had fillers approx 7 years ago for scarring before Pfs ramped up and they lasted 2 years I’m worried that they’ll degrade quickly because of where I am now. Are the benefits still visible even though I appreciate you only had them recently. Regards laz
It depends on the filler type. I’ve experienced with both Juvederm voluma and Belotero volume. They’re of denser hyaluronic acid formulation and would last about a year on paper. I had 1ml injected each time and notice that I needed less with subsequent procedures. Yes, results are quite visible and I’m a happy camper. Soreness/Inflammation usually settle after a few weeks for me. @LazarusRy
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My results show leukocytes in urine as well, but the doctor said nothing about that. maybe because there was no range in the report hence no red flags raised. Doctors hardly spend 30 seconds screening blood work results, so they just look into the out of range column. I wish the doctor I see was a computer, it would not miss this.
Doctors are programmed to look for emergencies, not improving quality of life. By definition, we are “hypochondriacs” to them.
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