???
Tzinkman’s article talks about AR overexpression in rats and the inverse U-shaped effect.
Nowhere does he say that’s the cause of PFS. The point of the study was to investigate the effect, which is good. But doesn’t mean it’s what’s causing PFS.
So how are you so sure that “damaged receptors” are what’s causing PFS?
Well, I can’t be so sure truthfully, because there’s no hard studies on it yet, but based on the upregulation of them and increase in density that is my hypothesis.
I’ve noticed a lot of improvements with some of my symptoms.
In your view, would it be possible for receptors to be repaired at least somewhat for some people?
Yeah, they could be. Especially with human growth hormone. Look into that.
But for some people, make no doubt this is a persistent condition that can not improve for upwards of 20 years,
hi, guys,
I’ve had a very stressful week at work. The truth is that I’m having a hard time keeping my job (I’ve been at it since February and not being able to leave work…I think the stress might make it difficult for me to recover)
What I’ve noticed this week:
- The skin all over my body is like rubber.
- The first week and a half I was better about the erections but it has gotten worse (I don’t know if it’s the same anxiety)
-Dry skin is exactly the same and I haven’t started any protocols yet. - I’ve had wrinkles on my hands
- The “old man” face doesn’t get any better. I’d even say the symptoms have worsened by leaving finasteride
-It’s weird, I’ve seen some hair growing on my forehead. But it’s still flaky and dry on the scalp.
What do you recommend? I had thought of buying collagen peptides, BCAA and do not know if to include some supplement that enhances growth hormone.
Tomorrow I’m going to do the first post-finasteride tests. I prefer that there be a hormonal alteration so that these symptoms can be explained. The endocrinologist told me I might have hypogonadism
1 Like
I would say the time is the best healer in the beginning and implementing supplements so early can miss out the time as a healing factor.
Are you still using oral minoxidil? Minoxidil is known for causing wrinkles and dry skin
Ask your endocrinologist to prove his hypogonadism theory by doing labs. As victims of this drug that poisoned us, we need absolute proof, and that can come by way of lab results. Hopefully, what affected us is detectable and measurable, otherwise we won’t be believed.
Hi, guys.
I come to you with news. I finally got results for my blood test. It is still pending confirmation of DHEA and DHT levels. But so far I have obtained something very interesting.
In view of this I would appreciate it if you could help me see what has happened in my body
Pre Finasteride Test:
TSH 1.02
FREE T4 1.09
Testosterone 7.04
Post Finasteride test:
FSH 4.04 mUI/ml (1.5 - 12.4)
LH 5.88 mUI/ml (1.7 - 8.6)
17-Beta estradiol 51.60 pg/ml (11.3 - 43.2) ***
Progesterone 0.35 ng/ml (0.05 - 0.149)
Prolactin 9.69 ng/ml (4.04 - 15.2)
Intact Parathormone 46.60 pg/ml (15 - 65)
Testosterone 8.08 ng/ml (2.49 - 8.36)
Free Testosterone 130.10 pg/ml (54.7 - 190.63)
Delta-4 Androstendiona 2.23 ng/ml (0.6 - 3.1)
ACTH 22.40 pg/ml (7.2 - 63.3)
cortisol 14.00 ug/dL (4.82 - 19)
25-HIDROXI VITAMINE D 15 ng/mL ( >30)
HDL Cholesterol 50 mg/dl ( >55)
Hydroxyprogesterone 17-alpha
IGF-I (Somatomedin C) 162.00 ng/ml (109 - 257)
Insulin 5.62 µI/ml (2.6 - 24.9)
Serum SHBG (Sex hormone 50.30 nmol/l (18.3 - 54.1)
binding globulin)
Thyroid Profile
Anti Microsomal TPO <9 IU/ml (Inf. 34) Negative
TSH 0.87 µUI/ml (0.4 - 4.5)
Free T4 1.16 (0.7 -1.9)
Anti Thyroglobulin (TG) 10.90 IU/ml (Inf. 115) Negative
High levels of progesterone (x3), estradiol, low vitamin D and HDL and testosterone slightly higher than before starting finasteride
What do you think? Are they typical of pfs?
After seeing my blood tests my IGF1 values seem normal. I really don’t know what steps to take from now on.
I would like to at least regain the elasticity of the skin and the loss of subcutaneous fat in the face. I have especially dry and wrinkled skin on my hands and feet since I left finasteride.
Do you recommend it in my case too? I’m having a very bad time and lately I’m only thinking of killing myself.
I got news for you guys.
I was with an endocrinologist yesterday who specializes in PFS. He recommended me to start with a treatment to be able to revert the symptoms, however I don’t trust it completely and reading experiences of the forum I don’t know if this will be a good treatment. The treatment would consist of testosterone injections every 21 days (but I don’t think that’s reliable knowing that I have high testosterone)
The regime would be:
- Testosterone injections 250mg every 21 days (5 in total)
- injections of follicle-stimulating gonadotrophin (FSH) and luteostimulating gonadotrophin every 21 days (HMG LEPORI)
Tamoxifen 20mg daily
cialis 5mg daily
bupropion 150mg
I’m actually quite doubtful about the treatment. I think it’s been a short time since I left treatment and I don’t know if this could make things worse. I told the doctor several times that I didn’t understand about injecting testosterone with high levels…
1 Like
Your test is already near the upper range. What is the point of getting the test shot?
1 Like
I don’t understand it very well either. He told me that the idea was to reverse the whole process “backwards”. I’m going to ask for a second opinion, since I see that it’s quite far from the stories I’ve read in the forum. In other words, it would be better to wait for the moment.
I got another blood test result today and of course it is also wrong … it gives me a very high value. The worst thing of all that in my case the endocrines do not know how to interpret it
Hydroxyprogesterone 17-alpha: 2.61 (0.05-1.6)
Dr. Erwin Goldstein could always give you a second opinion. I am skeptical of these doctors that pretend to know so much about PSSD, PFS, PAS. If it were that easy then this forum would have found out the solution long ago.
4 Likes
Would you be comfortable sharing the name of the doctor? There currently aren’t really clinical PFS specialists insofar as researchers with the greatest insights into the condition all say much the same thing: we don’t know definitively why it’s happening and more research is required. I doubt any doctor cognizant of the existing literature on the condition would be positing treatments to reverse the symptoms (I believe doctors like Goldstein acknowledge that they’re just trying traditional endocrine therapies in the hope something sticks). You are right to be highly sceptical of the “treatment” he has proposed. For more on why increasing your androgens exogenously might not be the best approach
1 Like
I finally refused to do that kind of treatment. If you want to know about the doctor I can send you an MP, however from my impression I do not recommend it.
Recently, I told him about my doubts, and he proposed a different treatment: HCG every month and clomid with tamoxifen diary in order to restart HPTA. This approach sounds better.
On the other hand I comment that my case is evolving very badly. I have been suffering for a few weeks with very strong pain in the penis, un flaccid state feels hard and I feel also the muscles in the pelvic area are very soft. The skin symptoms have not improved and I still have very dry skin (I don’t think this symptom will ever get better).
I have repeated the tests a few days ago and I have been surprised: testosterone and estradiol is still higher than in the last tests.
Testosterone 9 (2.49 - 8.36) previous was 8
estradiol 65 (<40) previous 51
The only thing that has improved is the progesterone which is already within the range.
If you want I can share my last complete analysis. My theory is that my body is still functioning as if the finasteride were still in my body. I believe there is a clear relationship between Blood test and my worsening.
1 Like
It’s much more likely that your AR and ER are silenced, so even with exogen TRT, you can’t see improvements.
In my situation, TRT worsened my situation.
1 Like
Did you check your Test level pre-TRT ? i think people with a test level in the 600s range shouldn’t use TRT
Yes, my pre-finasteride testosterone levels were lower (7). I find it very curious that when I stopped the medication and repeated it a month, they were at 8 and now three months later at 9.
I suppose in my case it would make sense to try clomid or some aromatase inhibitor with HCG. I’ve seen several such recoveries. However, I think that might further decompensate testosterone.
I don’t know what protocol to follow, maybe one option would be to go natural and use a DIM supplement.