@Jaime, @Dubya_B, @awor
Thank you. I know that my best course of action is just to wait it out and not take anything else presenting any risk. Except I thought about trying GHB before the cordyceps and that would’ve been safer. I thought about going to the doctor today, but I don’t want to be ridiculed and emotionally hurt again by him and really, what he could do but to prescribe benzos to me which I’m paranoid of taking due to its long-term carcinogenic risks.
Having PFS is a lonely enough battle, but to be dramatically worsened by taking Weird Shit on top of it is just too much to bear. I could use the morale to temper the crushing loneliness of what I’m going through. It’s hard not to catastrophize when the ability to sleep itself is gone.
It’s also stressful to be kept in the dark and if having a rough idea of what might be going on even if it’s just a wild ass guess would ease my mind for just for a minute or two, I’ll take it.
I know how valuable everyone’s time is but if anyone has any meaningful input to this I’ll appreciate it. I found this from the first study:
When infused into the MPOA, cordycepin, an adenosine analog that
decreases cytoplasmic accumulation of mRNA, blocks the ability of TP
to reinstate or maintain sexual behavior in castrated male gerbils. These
data, like those of Quadagno e? al. (1976), suggest that T activates male
sexual behavior by altering gene expression in the MPOA. Cordycepin
also counteracts T’s metabolites. Thus it does not impair mating simply
by preventing T metabolism. Nor does it act by destroying MPOA cells
since mating resumed when cordycepin infusions ceased. In other cell
types, cordycepin preferentially affects polyadenylation (Brawermann,
1976; Darnell et al., 1971; Sawicki et al., 1977). Hence’T may activate
male sexual behavior by inducing synthesis of polyadenylated (poly-A+)
If direct inhibition
of translation contributed to, or even accounted for, cordycepin’s effects
on male sexual behavior, the data would still be compatible with the
hypothesis that T promotes mating via synthesis of mRNA. However,
they would also be compatible with the hypothesis that T acts cytoplasmically, for example, by affecting polypeptide chain initiation or
elongation. Similarly, they would support the hypothesis that T affects
transcription of tRNA and/or t-RNA, rather than, or in addition to, mRNA.
The latter possibilities also arise because cordycepin affects these processes
It later concludes cordycepin inhibits sexual behavior in gerbils by blocking polyadenylation of poly-A+ mRNA. It’s not clear whether or not cordcepin itself is a 5ari, I think it’s suggesting it’s not a 5ari but maybe the other constituents in the pills I took could be. Seems like its antiandrogenicity is due to blocking mRNA transcription.
Thank you so much. So you recovered to baseline after those grueling weeks?