Excellent observation @Finfina . I’ve noticed similar pattern with HGH. I experimented with low dose (1 IU/D) with and without cortisone in the past.
HGH + Cortisone: improved sense of well-being + increased libido + leaning effect.
HGH solo: Literally felt like I was on nothing & increased fatigue! My TSH went up from 1.2 to 2.2 and experienced symptoms of hypoglycemia (low blood sugar). I was surprised as to why HGH didn’t produce the same results I had the first time around. Found out later that Cortisone is necessary in my case. So, my simple anecdote (n=1) made me believe I’ve potential adrenal insufficiency syndrome.