NASs, particularly ALLO and pregnanolone, are reportedly decreased in both the cerebrospinal fluid (CSF) and the plasma of untreated patients with major depressive episode.13,14 Antidepressant treatment with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine, also used to treat anxiety disorders, normalized the ALLO and pregnanolone content of the CSF, and there was a correlation between improvements in symptoms and increase in CSF levels of ALLO and pregnanolone.
It seems that those with depleted levels of neuroactive steroids in their plasma and cerebrospinal fluid (which it seems like we all might have, based on the abstracts from the February conference) are treated with one of two different SSRI’s: Fluvoxamine or Fluoxetine (Prozac). There are no reports of Fluvoxamine use on this site, and few of Fluoxetine use. It seems like those who took Fluoxetine at a very low dose reported improvements in mental sides. Is this something we should consider and/or something you have tried and can offer advice?