PLEASE try it. Every time you have tinnitus your dopamine receptors are messed up and put you even deeper to the ground. I’ve been where you are with Tinnitus (search my posts for this).
Just this one last try…i wouldn’t insist so much but your problems are much the same with mine.
I’ve been doing the methylation protocol for just three days now and have felt horny the past two which is very rare for me since I busted dat nut yesterday. The downside is I’ve had a bout of brain fog that took me back to when I had first PFS crashed. It seems only one of my heads can work correctly at any given time
BrongFogBoy, I had to slowly titrate up in dosing. I started with a crumb of B12 a crumb of a B-Complex and had to drink coconut water because of low potassium.
I know others have the same experience.
thanks for the resopnse, I’ve been taking b12 and b-complex for awhile now with no issues, I think it’s the NAC so I’m experimenting with that dosage and will add some potassium. How have you been feeling / progressing?
Ah! Yeah, this thread doesn’t endorse NAC.
I did titrate up so I can handle NAC. I do like to take a tablet before an after a drink. It reduces the hang over effect for me.
if Adrenal are affected , fixing cortison only will not the issue as many hormones are affected.Maybe bovine or sheep adrenal glandular can give more improvement.
The methylation protocol called for glutathione, as I understand it has to be taken as NAC because regular glutathione doesn’t really get absorbed. Do you know what the consensus is on supplementing the glutathione?
A bath with magnesium sulphate (epsom salt) restore the glutathione.
affected people also excrete large amounts of a compound called 5-oxoproline in their urine (5-oxoprolinuria). This compound builds up when glutathione is not processed correctly in cells.
Somebody tested on this?
Nope, but i just been yesterday to my blood analysis clinic and the lady told me to come in the morning because there was another person i. The morning and he didnt know anything about gluthatione sah and same…and others
I’m eager to get my functional methylation pathway tested but it seems you needs a doctor’s orders. How do you guys approach your doctor to get this tested ?
Hey, from the notes i took from phoenix rising forum and amy yasko’s book, these can help you:
Names are in portuguese but you’ll see they are almost the same… Thebapproach is:
1-get an insurance
2-get a fubctional medicine doctor to prescribe it or order them yourself through the insurance
Good luck
Serum:
Urine:
Thamks xptriado. I ordered test below and 23andme. Now I just need to find a doc to sign off on the methylation panel
Haven’t read through this entire thread yet but I have a question and a comment.
First, what glutathione form are we talking about? Glutathione (GSH) or Glutathione disulfide (GSSG)? I am guessing we are talking about the reduced form (former) rather than the oxidized form (latter).
I’m no expert on glutathione. All I know is it is a powerful antioxidant. This theory on low glutathione and the pathogenic origins of finasteride-syndrome make sense.
Glutathione (GSH) is a tripeptide that contains L-cysteine, L-glutamic acid and glycine. It is the smallest intracellular protein thiol molecule in the cells, which prevents cell damage caused by reactive oxygen species such as free radicals and peroxides. Glutathione exists in reduced (GSH) and oxidized (GSSG) states.
Reduced glutathione (GSH) is a major tissue antioxidant that provides reducing equivalents for the glutathione peroxidase (GPx) catalyzed reduction of lipid hydroperoxides to their corresponding alcohols and hydrogen peroxide to water. In the GPx catalyzed reaction, the formation of a disulfide bond between two GSH molecules generates oxidized glutathione (GSSG).
Glutathione reductase (GR) recycles GSSG to GSH with the simultaneous oxidation of β-nicotinamide adenine dinucleotide phosphate (β-NADPH2).
In healthy cells, >90% of the total glutathione pool is in the reduced form (GSH). When cells are exposed to increased levels of oxidative stress, GSSG accumulates and the ratio of GSSG to GSH increases. An increased ratio of GSSG-to-GSH is an indication of oxidative stress.
So it is formed by amino acids. GSH is converted to GSSG via Gpx. Then , GRx recycles GSSG back to GSH. According to mainstream science, you should have higher ratio of GSH to GSSG. Finasteride somehow impairs GPx and the GRx enzymes. So in theory you’d have more GSH at first, but then you have poor glutathione recycling…so, I wonder if taking more glutathione, cysteine, would be beneficial…
https://www.nature.com/articles/s41598-019-42251-5
In the study above, reducing glutathione actually resulted in better cancer therapies. The cancer cells themselves used glutathione as an antioxidant protectant against apoptosis. It’s interesting how under certain circumstances something is good and can mean life, and in others it is bad and can mean death.
For those of you supplementing glutathione, have you noticed a worsening of inflammation? If the viral or pathogenic theory is correct, I would wager that you would experience an onslaught of worse symptoms, followed by improvements.
Why followed by improvements?
I think that introducing glutathione could cause detox symptoms. Basically, as you jumpstart the detoxification pathways you will mobilize a lot of toxins and pathogens out of the body. I don’t think you will feel very good. You should experience inflammation if glutathione is working properly.
Similarly, if one goes off of finasteride, one will feel like shit depending on how long one has been on it for. That’s because in essence you are doing the same thing (up-regulating glutathione and restoring the innate immune response).
Remember, finasteride actually increases cortisol, an immunosuppressant, as well as reduces glutathione. So while it prevents the removal of toxins and metals, it also allows these thing to gain access in the first place. For those of us who had viruses or pathogens beforehand, this could mean that finasteride just let those things run unchecked.
This is why we could all be experiencing lots of “autoimmune” symptoms. I posted in the past about autoimmune and about copper/zinc status. I personally think all of these theories are driving at the same thing but are just different mechanisms of explanation.