What was the does and brand of the T4 and NAC I might give it a shot
1 Like
After taking fin, I was unable to orgasm or ejaculate for a very long time, is that the issue you guys here are describing?
No our problem is a lack of sensation during orgasm. I can reach orgasm very quick if I want to (within 1-2 minutes).
1 Like
I think I may have had that problem as well, previously when I was able to ejaculate, I had very watery semen. But I donāt remember for certain as my problem was mainly being unable to orgasm or ejaculate initially.
I was able to fix it with TRT and arimidex, but Iām not sure if thatās the same problem you guys are dealing with. My estradiol was also 59 previously, I believe on a range of 10 to 50.
Hey man, i remember you had a temporary recovery period right? Did this issue resolved 100% when you had that period. I just need some hope these days, i need to believe this situation is not permanent and can be reversed as what it was before the poison we took. Some other details about other sexual issues would be good too thx.
Can dopamine agonists be the answer? It seems to be a temporary effect.
My libido and erections are 100% recovered. Sensivity is at 80-90%. But I still have shrinkage and orgasms should feel way better.
I only had one temporary recovery of my orgasm when I reduced my T4 and went into calorie deficit. This caused a drop in androgens and my AR in the brain area that controls pleasure was recovered. Worked only once.
1 Like
what you think helped you to recover ? have you been takin anything ?
Read my old posts in my profile.
I know this thread is ten years old, but I think I have been experiencing this lately. Iāve noticed that lately Iāve still been stroking through my orgasms when I masturbate. Iāve wondered why this is, and I think itās because I donāt really feel like Iāve orgasmed. Not that I used to have earth-shattering ones or anything, but lately I feel like Iāve only been feeling the tiniest bits of pleasure.
Do you guys with orgasming issues have high E2?
I recovered mine for 5 weeks in 2017. I took Mifepristone which blocks prog, cortisol and androgen receptors. When I came off of the drug I experienced about an 80 percent recovery in all of these sexual sides. Than I went back to baseline.
The theory that is that when I blocked my down regulated prog, cortisol and androgen receptors they up regulated in an attempt to react with prog, cortisol and testosterone. When the Mifepristone left my system my receptor sensitivity was now what they needed to be to react to hormones normally. Than the underlining issue (what ever that is) down regulated my receptors again. I look at PFS as a receptor sensitivity in balance. For some reason when we inhibit DHT and the neurosteriods our receptors go out of wack and canāt recover back to their normal way of functioning.
Just a theory obviously
1 Like
Thatās interesting because most theories here think that the receptors are upregulated
Yes I agree. Only problem with that why did Mifepristone give me a temp recovery back in 2017. Mifepristone blocks prog, cortisol and androgen receptors. So when you block receptors they are going to up regulate in an attempt to be able to react with their designated hormone. If my receptors are up regulated than you would think up regulating them more would make me worse.
I just finished my 6th cycle of Mifepristone since 2017 and I have yet to become worse from taking this drug. Itās no results or positive results.
Of course one explanation is that those of us who are sensitive to DHT inhibitors could result in up regulated or down regulated receptors. They could down regulate in response to the increase in testosterone and or the surge of DHT upon stopping the DHT inhibitor. They could up regulate in an attempt to try to react with the lower level of DHT and allopreg while on the DHT inhibitor
There is tons of evidence that suggests different cases of PFS based on how different people with PFS react differently to taking different things. If this is true the common theme still remains among us. Why do our receptors go so out of wack while on the DHT inhibitor and why donāt they recover.
Research is pointing towards abnormal regulation and reaction to the stress hormone cortisol as a cause of PTSD. In other words the GC receptors are out of balance resulting in either too much or too little cortisol getting released or not getting released causing the typical PTSD side of always feeling on edge
Some think that PTSD is similar to PFS or at least has a similar mechanism
Thatās what this feels like to me.
I got worse with taking creatine and tons of other amino acids last winter. I was doing fine in the first few weeks, improved me, but then i now getting slowly worse and worse. I had low semen volume issue, but my semen is now barely comes out and i have a bend on my penis. I really want to give up on life if things donāt resolve soon or later.
1 Like
Some feeling a little better on creatine and some getting worse on creatine further illustrates this point. Different cases. Like how optimally vitamin D levels make some people worse and some people better. Both examples are increasing our hormones. So it makes sense that if you had overly sensitive up regulated androgen receptors that increasing your T and DHT would make you feel worse. And the other way around if the androgen receptors are down regulated.
Receptor imbalance is the best way to put this theory.
All the symptoms you describe are the typical androgen deficiency symptoms despite either not being androgen deficient or correcting your androgen deficiency and getting worse or not getting better
It all seems like receptor imbalance that probable has vast complicated implications on other receptors that either down regulate or up regulate trying to correct the problem. All this is just theory obviously.
If Iām right finding a solution will first probable require us to find the common factor among us that results in our receptors becoming imbalanced in response to temporary inhibiting DHT
In my opinion I donāt see that happening from studies. Itās going to take a ton of us to do our own experiments and getting our own labs done to try to find what many have not been able to find yet for a long time
For example, I get better or at least do not get worse every time I block my prog, cortisol and androgen receptors with Mifepristone. I get worse every time my cortisol goes up.
How do I know this? From taking risks and spending tons of my own money doing my own experiments. What I have learned about my own condition is light years ahead of the studies
2 Likes
I took creatine before going to the gym, like I always used to, about 21 months ago (3 months into PFS) and it fucked me right up. So I am definitely an adverse effects from creatine person.
Around that time I had genital numbness, little sensation during ejaculation, etc, which have improved over time.
I have found that my sensitivity and orgasm and ejaculation sensation seem to increase on bulgarian tribulus cycles.
I recently interested in this theory. During an orgasm, the pelvic muscles around the prostate move rhythmically. But our pelvic muscles are not. The force to push out the semen is very weak.
Yeah! I think its hormonal related thoughā¦ because what else it can be?
You can experiment with yoga, pls do the pelvic floor yoga and see if you can feel the muscles. Lie down, and try to connect it. I posted a good yoga video on the big pelvic floor- pfs thread.
Hi, thanks for that link. Did you able to reverse this symptom? Even temporary maybe? I started kegels, donāt know what to try elseā¦