according to these FREE papers
besides sensitizing leydig cells, the androgen/estrogen receptor, cAMP/cGMP + a bunch of the steroidogenic genes doxazosin modulates key enzymes that among other things decrease pregnenolone AND progesterone levels
*this obviously affects signalling which we are interested like
– pregnenolone > - allopregnenolone > - agonism at gaba receptors (which is elevated on PSSD - PFS users)
– progesterone > + estrogen receptors & - crossover with the AR(helps with the negative feedback and libido)[1][2][3]