Dont be surprised if dopaminergic drugs stop working due to this effect
Love this post
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In terms of dopamine receptors and dopamine levels, I tested my DNA and it was confirmed I have a recessive homozygous gene that makes me have low receptor amount and dopamine release.
I too have issues waking up and getting going in the morning, along with other low dopamine symptoms.
I would not be surprised if we all tested this gene and we are similar. The 5AR inhibitors pushed us to the limit and messed up our neuro chemistry.
We have to find ways to increase our dopamine receptors. Exercise is one way to do this. Not sure of any other safe ways to do this.
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I canāt confirm this through literature, perhaps @axolotl can answer in more detail.
But, in one way or another Androgen and/or the AR activates or potentiates Dopamine response.
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Anyone here tried taking Provigil/Modafinil? I get good results from it for mood. I also get good results on mood from Amisulpride at low doses, where it functions as a D2 agonist.
Due to pfs ? youre right! im using mucuna prurien (l-dopa) since pfs and it changes nothing !
I can only speak from my personal experience and say that life can be very hard, it can constantly knock you down one punch after another. In the past 5 months my nanny past away, Iāve lost two friends to cancer and a close family member tried to commit suicide.
Iām very sorry to hear what your step sister is going through as I wouldnāt wish cancer on anyone, itās a truly awful disease.
Iāve been working the last 5 months, getting payed minimum wage with emotions I canāt get much joy from, I come home everyday and just sit there hoping to enjoy playing a game or whatever, most of the time I just get bored or canāt get immersed in anything.
Trying to function in work when I find it extremely hard to think with the brain fog is a constant challenge, Iāve just been drinking coffee and energy drinks to keep me at some sort of cognitive level, probably not the best idea but sure it helps me think a little easier.
I canāt feel what sex is like because my gentiles have been desensitized from antidepressants the past 5 years. My vision makes doing tasks difficult and its extremely hard to work when everything is blurry and looks like a faulty signal, with the amount of static engulfing everything around me, things donāt actually look real to me.
I could go on and on about different things and how each day is a challenge, but one thing Iāve learned about myself dealing with all this is that Iām resilient, no matter how bad things get I seem to get somehow be able to just keep trudging forward , maybe itās the hope that advanced tech or Ai will eventually find solutions and make life more enjoyable again, maybe itās because I want to see what happens and not end my story prematurely, maybe itās because I care for the people around me, I donāt exactly know what it is but I very much want to live, I didnāt at first with all this but I certainly donāt want to die.
All I can say to you is that there are a lot of us in bad situations, but weāre all in this together as a team, we need to support one another and keep fighting, without people fighting and trying to do the best they can, this forum wouldnāt even exist and none of us would have the slightest idea whatās wrong and probably feel extremely alone. We at least know thereās a lot of us and I do think there is an end to this if we just hang on.
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Provigil does help my mood and motivation. Makes me feel more like my old self. I get more done, am more open to taking appropriate risks, and feel better. Only downside is it takes so long to wear off I have trouble falling asleep that night and canāt do heavy cardio while on Provigil.
@Devolution thatās the best post Iāve seen on here in a long time. It represents and attitude we should all be trying to mirror and itās certainly given me some motivation during an extremely tough time Iām currently going through. Stay strong man.
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How much do you take? I take 5mg at rise.
its not your task to save me but im thankful! i just cant cope with this any longer. When im realistic it seems so freaking complicated to solve our problem. Modern medicine is not so far many of us might believe. i see it every day.
We donāt know what the problem is. Once we put the herbs down and get organized to stimulation actual scientific interest in our situation then weāll learn what the issue is and acquire a treatment for it. No need to sit around speculating worst case scenarios. Just get the science done.
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Has anyone tried caber for their dopamine issues.
I used Caber, but didnāt work
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50-75 mg/day, but I donāt take it every day. You mean 50 mg? I didnāt know you could get modafinil in doses that small.
Use the search function my friend!
There was much talk of dopaminergic substances on this site in the past. Results varied.
Sorry, yeah, half a pill or less. Maybe the optimal for me is 1/3rd, so around 30mg.
why i cant read what you wrote to me ?
The only realistic way to boost dopamine is throught sex hormones. Estradiol regulates emotions thought oxyticin and kisspeptin. T boost dopamine.
- Being in love is a hormonal phenomenom.
- motivation from T
- bounding from E2
That video isnt going to work. But i agree that fasting is nice
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