Funny how everyone was dissing on my potential treatment then we’ve got lord and saviour Goldstein suggesting the very same treatments.
Daily use of low dose amphetamines is not neurotoxic. Meth however has been shown to be neurotoxic in doses of 10mg.
Meth allows free radicals to build up and oxidisation occurs. It does this because it blocks reuptake, releases wayyy more dopamine AND does it for a long time. This is why amp is also neurotoxic in high doses, blocks reuptake and releases (no where near as much dopamine which helps reduce free radical build up) and also not for a significantly long time.
The brain isn’t going to like receptors that reuptake blocked by stims that are releasing dopamine too much and too long, thats why cocaine is literally not neurotoxic. It’s because it only blocks reuptake mostly so it struggles to release the amount of dopamine required to exist for free radicals to build up. Also explains why amp and meth make you insanely focused and motivated but coke lacks that effect.
Neurotoxicity can be permanent if cell death occurs but all dopamine drugs lower dopamine levels for sometimes months after depending on how much you used them. How well you bounce back and how quick depends on the neurotoxicity produced.
Cocaine for example, super easy to bounce back from. Never noticed and demotivating effects from coke, with amp and meth comedowns make you sit at a wall staring doing nothing clear sign dopamine struggling to recover. Three month meth abuse took me 2 years recover from, 3 to really stop feeling the super harsh effects. Neurotoxicity mostly comes from binging though, sleep and you’ll reduce the harm you do ten fold.
It’s a little more complicated than I’ve laid out but it’s the general idea. Low dose amphetamine is a concern for the heart but not the brain, even meth has been shown to be neuroprotective at low doses for people who’ve had concussions. So it’s a very very complicated thing.
One thing I will say is meth fucks serotonin too. And that takes a LONG time to bounce back and is way more likely to be permanent. MDMA gave me the absolutely awful low serotonin symptoms when I abused it, I had to sleep with the lights on due to anxiety lmao. This is why rollsafe recommends once every 3 months for mdma but you can take drugs like coke weekly and so long as your heart doesn’t pack in you won’t end up an etard.
Btw all drugs are bad that’s why we’re here. This is a disclaimer so no one rants at me, I’m just offering my thoughts and what I’ve learnt spending years researching the mechanisms behind different drugs. It helps you understand why they produce the effect they do.
