Do we have normal level of P450 family enzymes?

As I am looking into it I am becoming convinced our P450 enzymes are no more normal. We need to investigate it. Maybe CYP3A4 and other P450 enzymes are permanently turned off.
P450 deficiency can affect vitamin D, Testosterone, DHT etc. Almost all of the drugs or substances we have used to cause PFS are P450 inhibitors.
These have been causing PFS like symptoms and all are inhibitors of P450 mainly cytochrome P450 (CYP) 3A4
Trigonella foenum-graecum (Fenugreek) : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621675/
ketoconazole: https://pubmed.ncbi.nlm.nih.gov/21235585/
Saw Palmetto (Betasitosterol ): https://pubmed.ncbi.nlm.nih.gov/17336049/
Curcumin : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770025/
Anastrazole (Arimidex): https://pubmed.ncbi.nlm.nih.gov/9152599/
Accutane: https://www.rxlist.com/accutane-drug.htm#interactions, https://pubmed.ncbi.nlm.nih.gov/15116059/
Metformin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205227/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978432/
ciprofloxacin , Fluoroquinolone : https://pubmed.ncbi.nlm.nih.gov/8894516/
Green Tea: https://pubmed.ncbi.nlm.nih.gov/27518169/

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from Wiki
[3] Symptoms of severe forms of PORD include ambiguous genitalia in males and females, congenital adrenal hyperplasia, cortisol deficiency, and Antley–Bixler skeletal malformation syndrome (ABS), while symptoms of mild forms include polycystic ovary syndrome in women and hypogonadism in men.

@headsup theorized that many of our problems are due to P450 inhibition.

Are there any supplements/medication that can fix p450 enzymes?

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At this stage it is a theory. We will have to go through some lab tests to find if we really are deficient in P450, if yes then which P450 enzymes?. The treatment option will come later if the theory is really proved true.

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I also feel Lyme disease, Celiac disease, IBS and some other allergies are linked together through the impairment of different enzymes of P450 family.

Here you go


Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate’s strong ability to chelate these elements.

I had undiagnosed celiac disease with daily gluten consumption during the time I took finasteride and developed PFS.

Alex50 can you still you use Gluten ? Or yourMaybe it has now intensified.

how your celiac has changed after pfs?