Brain damage and epigentic changes


#1

I thought this was pretty interesting. Maybe someone smarter than me can interpret it. It discusses how TBI can cause epigentic changes and also other bad stuff


#2

Interesting. I guess that’s why Dr. Mark Gordon treats PFS like Traumatic Brain Injury.


#3

Gordon helped me but you can do the same thing with a few hundred dollars for the supplements. Clomid and testosterone and needles…He costs a fortune and labs are through the roof just to tell you that your hormones are all back to normal but you are far from normal

You are looking at about 5k for all the testing and supplies. And supplements Gordon charges a fortune to write a testosterone prescription


#4

I know, Goldstein cost a fortune too. My family is helping me out but I feel bad. The spinal cord stuff I might have going on and genital scarring is something I couldn’t do on my own. But the medications part I could have done I guess. I mean it’s good to have someone working with you and all but it kills me that we need these specialist and that most doctors have no clue.


#5

Yeah those guys who dont take insurance like Gordon and Goldstein are Hollywood doctors for the stars…Just the testing from Gordon is around 1800 he does telemedicine and you send your blood samples to Florida he uses one lab there.

So you don’t have to fly out there…The phone constellation is good he goes over everything with you and you get a report but only so much they can do…This type of chemical brain trauma to the brain and nervous system is largely irreversible in my opinion other than time healing at least you didnt get the physical symptoms I jumped from 160lbs to 260lbs.


#6

Damn that is a lot of money. Well I do have some physical stuff like peyronies symptoms, shrinkage, and dry, thinning skin and hair. I have actually lost weight though. I can’t taste food and I don’t get hungry anyway.


#7

It’s crazy how different all of symtoms are. I’m in great physical shape, but I literally can’t see straight. Living life in some sort of bubble.


#9

Guys stop scaring yourselves shitless reading this stuff… it’s not gonna do you any good. If it was brain damage, people wouldn’t experience temporary recoveries. Not to mention that I’ve greatly improved my own visual and neurological side effects, which are/were very similar to those of @Mcbbould and @Devolution.


#10

Great post, definitely worth reminding each other of the capacity for near instantaneous recovery.


#11

10 posts were split to a new topic: Recovery from Genital Numbness and weak Orgasms


#16

Epigenetic changes following TBI include DNA methylation, chromatin posttranslational modification, and micro ribonucleic acid (miRNA) regulation of gene expression variation. These epigenetic changes and mechanisms might not only be limited to the cell nucleus but also impact the function of mitochondria and neuron recovery processes.1 Metabolism of essential amino acids can alter gene expression after TBI, which is one potential mechanism of secondary injury. For example, ethionine metabolism provides methyl groups to DNA and histone methyltransferases to epigenetically regulate gene expression, and TBI can alter the methionine metabolism to affect cellular function in multiple organs and systems.38

Epigenetic changes following TBI may have implications for outcome,1 recovery, and therapy of TBI39; they can lead to devastating neurological disabilities that impair cognition, memory, movement, sensation, or emotional function.40 Enormous heterogeneity exists within TBI, and it depends on the severity, location, and whether the injury was focal or diffuse. These epigenetic changes might not only be limited to the cell nucleus but also impact the mitochondria, and such changes have important implications with regard to TBI recovery.1 However, predicting outcome following a TBI is challenging and cannot be made based solely on clinical presentation and radiological findings, since patients with comparable injuries may have variable outcomes. Therefore, the post-TBI genetic influences on outcome have attracted recent attention. Many genetic variations have been documented after TBI, including changes in neurotrophic factors, cytokines, nitric oxide (NO) syntheses, and tumor proteins such as TP53. Alterations in gene transcription for pathways related to DA transmission after TBI have also been reported.41,42 For DA neurotransmission, variants linked to DA D2 receptor (DRD2) and ankyrin repeat and kinase domain (ANKK1) genes were found in some individuals with different cognitive recoveries following TBI. Therefore, genetic variation in DRD2 and influences on post-TBI DA transmission may have important implications for cognitive recovery after TBI.43

The role of genetic factors in the interindividual variability observed in TBI has been examined in predicting functional and cognitive outcome following brain injury.44–46 Therefore, not only gene expression alterations associated with mild and repetitive TBI in combat veterans and professional athletes have been studied47,48 but also numerous genes have been implicated in the pathophysiology and outcome following moderate to severe TBI.49 A growing body of literature has been devoted to genes involved in TBI, including those that influence the extent of the injury (e.g., pro- and anti-inflammatory cytokine genes), those that affect repair and plasticity (e.g., neurotrophic genes), and those that affect pre- and postinjury cognitive and neurobehavioral capacity (e.g., catecholamine genes).50 In addition to single-nucleotide polymorphisms that reside in coding sequences and influence expression and protein production, gene expression may be altered without altering the DNA sequence by means of DNA methylation and chromatin modifications. Moreover, the role of epigenetic mechanisms in injury has been explored.51 For example, genes with biological function clustered to immune responses were significantly upregulated at 4 days after injury, but not at 1 day.52

My guess is most of the sides come from the following neuro inflammation in the brain…And Genes…Another guess is that the lowering of dht and upregulation AR in the brain and resulting return of DHT is a tramatic brain injury…


#17

Yes this could also explain the grace period before the “crash.” I wonder how damage could be so quick for some - like myself - with only a few pills. Most of people who have it the absolute worst - perception issues and derealization - get it after only a few pills. @axolotl what do you think about the article I posted in the OP?


#18

This also caught my attention…TBI has several possible outcomes and can affect many systems in the body…

For example, ethionine metabolism provides methyl groups to DNA and histone methyltransferases to epigenetically regulate gene expression, and TBI can alter the methionine metabolism to affect cellular function in multiple organs and systems.

I could only guess that the quick reaction for some could be an auto immune response in the brain…


#19

Better version


#20

I agree with him, I understand somethings wrong but we didn’t get smashed in the head with a brick im sure it’s not comparable


#26

Hey all can we try and keep this forum on topic. Created the thread to talk specifically about epigentic brain damage


#27

I’ve split those posts out into this topic:


#28

Another very likely scenario is it’s an enzyme dis order affecting various systems in different individuals…Different Gene’s could be affected altering enzymes that play a crucial role in metabolism…