Importantly, this paper about a “rebound” effect is strictly limited to hair follicles and hair growth parameters. It does not discuss anything related to adverse effects outside of hair growth. There’s no mention of androgens or receptors.
From the Conclusion:
The possibility of a “rebound effect” and hair follicle becoming “drug‐dependent” could not be fully appreciated with previous technologies used in trial protocols. There is some indication however that after 1 year off‐drug and re‐entering “on‐drug” period after drug interruption prevent complete regrowth of hair. Suggestive elements along facts unravelled during this pharmacodynamic study seem to support this “rebound phenomenon” and “drug dependency” hypothesis.
Regarding the use of the term “reflex hyperandrogenicity”: we can find lots of terms on the web or the forum that may or may not be useful, true or valid. For example I can search “flat earth” or “narnia” on the web and get many results, even though these are false or fictional.
If I search the forum for “keto”, “meditation” or “asparagus,” I get more than 50 results in each case. Does that mean each of these is relevant to PFS? I don’t think it’s been shown one way or the other.
I am open to any term, but my questions would be:
- What is the definition or hypothesis?
- What is the factual basis or rationale?
- How could it be verified?
I understand we’re not doing scientific research here on the forum, but if we’re talking hypotheses then I think these guidelines could help.