Androgen receptor overexpression and sensitivity to hormones reversed by epigenetic therapy that restores Pur-α to a transcriptional repressor complex of AR deregulated in HRPC

Ok thanks @Northern_Star

Yes but look for those that are pure B-HYDROXYBUTYRATE.

I read his thread, but not just his treat, I researched it, Methylprednisolone is a potent LPS and TNF-alpha inhibitor.
In a research it found to activate a silenced 5-alpha R2. I can send you the link if you are interested.

:face_with_raised_eyebrow:

4 Likes

Why ?
Something like this https://fr.iherb.com/pr/Primaforce-BHB-Beta-Hydroxybutyrate-Patriot-Pop-8-9-oz-255-g/79489

You’re goint to try ? If yes, which one, link ?

@Xorack Yes that seems to be a good one, but what I do not like is that have natural flavor.
But yes that it is dude.
I took 15 pills yesterday, split 5 5 5. I have the best sleep in years, but guys don rush yet, let me finish the whole bottle, I will update you in 3 days.

2 Likes

He meant thread obviously, doesn’t discredit what he’s saying because of autocorrect

Just a light-hearted moment.

1 Like

@ Lostinaustin, It is OK there is not justification for my bad English, bur I will love to read anything from Greek in another language, and I will say the same just a light-hearted moment… lol

Alas, you won’t get the chance. I can only speak English with confidence.

I’m sorry if I offended you, it was not my intention.

1 Like

Well I speak, read and write two language, and I am trying to learn a third one.
My English is not perfect, but it is good enough for me to communicate.
Corrections do not offend me at all, it is all the way around.
The only confidence that I care is when I am going to fuck…lol

2 Likes

My eyes are peeled. Which brand do you use? Are you on a regular or keto diet? I’ve been reading about potential safety concerns about taking exogenous ketones and the only thing that I’ve found is that it can temporarily prevent you from losing weight as your body’s natural ketone production is disrupted. But long term effects are unknown.

Here’s a comprehensive list of ways to inhibit TNF-alpha:

It’s a selfhacked article though, so take with a grain of salt.

2 Likes

I just bought a bottle of 60 pills in Amazon for $14, make sure that is only B-hydroxybutyrate with not flavor or others ingredients.
I am finishing the whole bottle today (I stated 3 days ago, 60 pills in 4 days, split 5 5 5 at day, the last 5 I keep it before bed time) , I sleep incredible good since i started 3 day ago.
B-HYDROXYBUTYRATE is a TNF-ALPHA inhibitor also LPS inhibitor and it is a potent HDAC inhibitor.
I believe that dosage and timing + what do you eat during the protocol can impact on the outcome, I prefer to fasting as a part of the protocol to keep inflammation low as possible, so it going to help to keep LPS low.

4 Likes

Have you consulted with an expert to know if superdosing exogenous ketones like that is safe at all? I believe you when you say you are experiencing incredibly great sleep and that makes me excited but I am also quite alarmed. Isnt it dangerous to try to improve our condition by so non-specifically shutting down such a general mechanism in the body. We also don’t know if that part of the pathway is the root cause of the gene dysregulation.

Let’s say its working and it’s targeting the right genes but wouldn’t what you’re doing (in the way of inhibiting HDAC) have systemic and genotoxic effects? Some chemo drugs act as HDAC inhibitors, they target one cancer but often have the undesired effect of provoking other cancers. Correct me if I am wrong.

It is safe, I am not concerned at all, I finished today a bottle of 60 pills in 4 days, and I order another one.
After Finasteride I am not afraid to any drug, there are not more dangerous drug out there than Fin and we took it.
Don’t worry, just wait, if I don’t die and get cure then you can take, give me a month or so I will keep you posted.

1 Like

Any source for this?

Bro, Google you will found out like I did.

1 Like

There is literally no one who has superdosed BHB like that that I’ve found online and I have not found any long term studies on taking supplemental exogenous ketones, as if such a thing even existed before the whole keto fad started. Do you mind linking to some sources?

Bro, I just too my last 7 pills and I ready to sleep, tomorrow I will send you some links.
If we still alive after talking Fin, I don’t have any doubt that taking an ultra high dosage of ketones will do anything worse.

2 Likes