Stem cells is so fucking powerful that even HVI had been cure with it, I do not have any doubt that it is very possible that stem cell can fix PFS, but stem cell have many problem before get in the market to treat neurological conditions, like delivery method, differentiation in the type of cell that is need it, FDA approval, etc…
Epigenetics and Psychiatric Disease
https://www.sciencedirect.com/topics/neuroscience/trichostatin-a
3.3.3 Role of HDAC Inhibitors in TBI Pathology
HDAC inhibitors such as sodium butyrate (SB), valproic acid, trichostatin A, suberoylanilide hydroxamic acid, and so on have long been studied for their role in normalizing the deleterious consequences of environmental factors including addictive drugs and stress.101 Similarly, recent studies also show the neuroprotective effects of HDAC inhibitors via restoration of histone acetylation in the frontal cortex and hippocampus of TBI-induced animals.
Sodium butyrate : Sodium butyrate, the sodium salt of butyric acid, is a well-known HDAC inhibitor, and competitively binds to the zinc sites in class I and II HDACs. The administration of SB on the 14th day after CCI injury increases global histone acetylation in the hippocampus. In addition, SB also improves CCI-induced deficits in spatial learning and memory, as well as fear conditioning due to TBI.54
And there are a lot more information in this page
4 Likes
Have you tried taking butryic acid/sodium butyrate? If so, did it have any effect?
Don’t want to speak for Moonchild, but I believe he recovered 100%, and I believe he did try this.
1 Like
Are you aware of anyone else trying it? Seems like a very straightforward, easy and relatively low risk protocol to try, given the ease of buying this supplement.
2 Likes
I have ordered some. Unsure if it will help in the case of PAS, but I will let you know.
2 Likes
People always say HDAC would be about (de)methylation, when in truth it’s literally about (histone) deacetylation, which depending on issue can be just as “powerful” or relevant as methylation, as can phsophorylation, for example. Acetylation and methylation can be linked and take each other’s places, sometimes, I think, i.e. deacetylation is required for methylation to take place, and if HDAC (deacetylation) is inhibited, methylation usually cannot take place.
However, as usual, it’s not as straightforward or simple as that either, since HDAC inhibitors usually show a pattern of demethylation followed by hypermethylation… (E.g. Sodium Butyate as a HDAC inhibitor, or any others, you can read up studies and some will mention such patterns if they are detailed enough. Bacopa is a herbal HDAC inhibitor.)
By the way, the opposite of HDAC is HAT or Histone-Acetyltransferase - this is what causes deacetylation. This is quite common in herbs, and I think the protein p300 is an important factor in it (like SIRT1 might be in demethylation or possibly HDAC). So one can check for either p300 (also often mentioned to be inhibited by various options) or HAT or histone acefyltransferase, instead of HDAC, for interest’s sake. HAT inhibitors I already know: Curcumin, Quercetin, EGCG (mixed, seems to do nearly everything…), Schisandra…
By the way, I am sure HDAC inhibition (for acetylation) is a major factor of Bacopa’s positive effect on memory and mood, and might be behind some of the receptor regulation processes that get most of the attention. I am sure one will also feel “hollow” and more confused after taking high doses of a HAT inhibitor for a while (although it can also be useful to some extent sometimes). These effects are usually said (and I think felt) to just take half a day or so in their onset, by the way.
Just my personal sidenote on the topic, not sure how it will bring anyone further right now.
1 Like
Yes SAW, I still recovered 100%, I just comeback sometimes to responds email…
8 Likes
I tried using butyrate it made me feel foggy and disorientated also caused joint pains to become even worse, I believe it activates the androgen receptor and probably boosts testosterone. Demethylation through HDAC inhibitors isn’t as straight forward as genes can become methylated and demethylated with these diseases. I think it’s either a) cag repeat disorder which seems plausible due toxicity and failure of DNA repair or b) a conformational change to the protein structure of the receptors through epigenetic mechanisms. I have no idea how this can be reversed if it’s b; perhaps a pharmacological compound will have to be used to put enough stress on cells to adapt to a lower androgen environment and induce an epigenetic rewiring. Note: I think PFS could be an adaptation to a higher androgen environment that’s has put us in a state of permanent insensitivity
1 Like
Anyone is going to try this HDAC?
1 Like
It happened to me to when I use it, also with BHB, made me feel very tired, but I didn’t give up and continue using it both until I started feeling result, it didn’t happened overnigh.
Now I am 100 % recovered…
4 Likes
Moonchild, are you still advising to fast?
Thanks for sticking somewhat around!
1 Like
what is epigenetic therapy basically? can you explain?
Do 5ar inhibitors cause AR insensitivity? Maybe that is why I need a lot of testosterone to feel normal.
You can also do fasting, it is good for your general health and also it help me a lot before, it could be part of my recovery…
I remember that i did fasting while taking butyrate and BHB…
Good luck
1 Like
Cool, one more question: How much bhb and butyrate did you take per day?
I can’t find butyrate powder, only capsules. Is that correct?
There is no a magic pill on it, but I believe this could help
1-Give it time and don’t give up…
If you start to feeling tired, fatigue stick on it, it will get better and a few days, it happened to me when I started taking BHB…
2-Too much BHB will give you diarrhea (use only 1/2 TSP = 2.5 ml ) in 62 oz of water drink it during the day…7 days a week (Band: Bulksupplement )
3-2 pill of sodium Butyrate before bedtime (Brand: BodyBio )
4-Walk for 1 hour everyday
5-Eat healthy avoid processed food, also sugar and alcohol…
6-Try to get a good sleep
7-Avoid stressful situation
So far this is the most and lest complicate protocol that anybody can follow and it work…
7 Likes
I bought calcium magnesium butyrate by accident. That should be fine too? I’m already using BHB.
Try it, probably is going to work as the sodium butyrate, but if no, buy sodium butyrate, it was what I used…
Remember give it time, it will not work overnight…
About BHB: You can drink a glass of water with 2 grams of pure BHB before bedtime with Butyrate…
Avoid heavy meals late at nigh…
5 Likes
After 10 months I can say BHB or sodium/calcium butyrate are not the cure, at least for me.
I tried first a low dose, then increased it with no success at all.
I ate meat for some months (keto diet) even if I’m vegan, made me worse (but doesn’t mean anything, because I feel worse for no reason).
I tried not to eat for weeks, nothing.
I came to the conclusion that time is the only cure. I regret I was too reckless and impatient, it was a disaster for me to try new things.
Be careful when someone’s saying “I found a cure”, it can be a step closer to hell.
3 Likes