Allopregnanolone pill -- coming in 6-7 years

Therapeutic Efforts Pharmaceutical
#29

has anyone ever heard of this?

longecity.org/forum/topic/63 … periments/

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#30

Yeah you can get it on online pharmacies. It’s popular in continental europe as an anti-anxiety treatment.

I’m not holding out too much hope but will be interesting to see if theres anything effect. I do think it targets the right mechanism, its funny how often finasteride is used in studies to counteract it’s effects. But I think the doses required for it to be effective are an issue, since it’s pretty heavy on the liver. Ganaxolone is probably the real lifeline. Unfortunately I imagine that won’t be on the market for another 2-3 years.

I wouldn’t bother with GHB if I’m honest. Feels more neurotoxic than beneficial.

#31

I’ve read that Sodium Oxybate, the GHB, is actually produced in our bodies. I’ve read it’s not neurotoxic at all but the problem is getting the dosages right because apparently it is not a linear or logarithmic progression in the effect aas you increase the dosage, but rather something exponential. Bear in mind this was what I read yesterday in a blog on how to make your own GHB so this is by no means something I read in a scientific study.

Ganaxolone seems to be the real deal…

I live in europe but for my insomnia/anxiety I only got prescribed these:

  • anti depressives
  • benzodiazepines
  • buspirone
  • valproic acid

i have only tried the AD’s and the benzos…they’re not as useful for me as I thought they would be.

I had epilepsy crisis too when i was 12, and medicated 2 years on phenobarbital (OUCH…), so I want to try an AED for my insomnia/sleep. I’m going to a neurologist specialized in epilepsy and sleep on the 18th of December. I wish he’d prescribe me Pregabalin. I’ll suggest that and let you know…

I’ve been trying this homeopathic product Gelsemium Sempervirens 5CH because I had read on a sci study on mouses that it increases Allopregnanolone biosynthesis…well…it’s hard to say if it’s doing something or not. …

#32

Has anyone else here tried allopregnanolone ?

#33

Homeopathy is bullshit. Please stop wasting time and money on pseudo science.

#34

I also dont believe in it but i found SCIENTIFIC studies about this particular substance and it was 5 euros On the pharmacy that is 10 meters fromy office, so i bought it. I hope thats ok for you…

#35

There’s nothing scientific about the concept of homeopathy, regardless of what substance it is.

#36

Too bad then that this was a study published on pubmed where they measured allopregnanolone before and after administration of the compound, in mice…

#37

DannyFc, did you ever try Etifoxine?

#38

Is there a natural way -other than alcohol- to raise allo? Or get it to be produced etc I don’t know the exact word for it. I’ve just started to get muscle twitches and it’s driving me nuts!

edit: Found this: 4abettermemory.com/memory/hormon … in-health/

“…Allopregnanolone is a metabolite of progesterone which is produced in the body. Progesterone comes the master hormone pregnenolone, and pregnenolone is available in this country as a health food supplement. If you’ve attended one of my classes you learned of the importance of pregnenolone as well as the hormone it produces – DHEA, estrogen and testosterone in promoting brain health, and how these are dramatically reduced by age, but can be boosted with this simple supplement which costs less than $25…”

Sounded like a scam to me but is there any credibility? I’ve searched over forum and read some conflicting ideas.

#39

Etifoxine did not help me or do anything at all, I bought it from awake brain, I also have emoxypine but haven’t tried it yet

#40

Just ordered etifoxine- worth a shot.

#41

Another thumbs down for Etifoxine.

#42

Guys, there’s a direct precursor to allopregnanolone that you can buy called 5a-DHP. It’s supposed to be very effective and the reactions from pfs sufferers using it seem to be very positive. Check out this forum on it: swolesource.com/forum/post-f … a-dhp.html

I just ordered mine, takes awhile to get delivered though.

Here’s the link to the vendor idealabsdc.com/lab/

#43

I’m just looking at that site now.

Do you know if the 5a-DHP has to be injected ?

#44

No, it does not have to be injected.

You can use it orally or topically. Topically will give you a slower, smoother dosage. Oral will give a more powerful effect

I was hesitant to use it at first because it is a research chemical with a disclaimer on the site but I have been in a bad place this week and decided to give it a run at a very low dose topically.

#46

How did the 5a-DHP work for you guys?

#47

It did two things for me…Jack and shit…

#48

That’s a bummer, seems to help some and not so much others.

#49

What happened? Did it go well?