Just sent an email to the recruitment contact. Hopefully I can get in and not get the placebo dose. If it does nothing for pfs maybe it will at least help with depression from pfs. Will keep y’all updated if they respond to me.
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Did you tell them you have PFS? I think that would disqualify you. The only way to get in those studies is to have prior diagnosis of the diseases they are testing SAGE on.
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I did not say I have pfs
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Update, received this email from the contact at sage I think anyone else interested should apply to the study as well so that we have a greater chance.
Question: if I have very low levels of Allopregnanolone like one of the studies suggests, would boosting it from barely anything to whatever levels the medication achieves be too drastic of an increase?
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Hard to say what the results of that increase in allopreg would be, man. Intuitively, too much of anything can be harmful. But I suppose part of the study would be to find a therapeutic window for patients.
I assume they will build dose gradually.
The worst thing from getting too much allo at once is that you become sedated and fall asleep.
They did this with their PK studies and found ~60mg a day of allo was enough for most people to feel sedated.
that email didnt even say anything. are they going to reply back to you or something?
After completing the survey at that link they sent me this email. So I’m hoping they find a testing site for me but if not I urge anyone else willing to try this to apply as well. Witchita Falls is a 5 hour drive from me and I just couldn’t do that twice a week.
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what happened to the location in Austin? filled up i guess?
That’s what I’m confused about. Either that or the agency that forwarded my information sent it to the witchita office by mistake.
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Baclofen is a Gaba-B agonist that raises neurosteroids. Might want to look into that before the other drugs because it is:
- available
- doesn’t mess with androgens according to literature available now
yeah please email them to clarify. would be BS if you can just get it in austin lol
thank you sir. have you tried this?
edit: a google search just spouted a bunch of withdrawal complaints…
Yeah I’ve been taking it on and off for a while, and I didn’t have any problems when I was taking it twice or thrice a week. Can’t say it’ll be the same for you, but this stuff really helped my mental sides at some point and my sleep as well.
I will note that I was on it and a benzo for a period of two weeks, and had some pretty bad withdrawals, and while I cannot rule out the baclofen contributing to it, I believe it was mostly the benzo and PFS in general. So I’d recommend just not taking it consecutively if you decide to.
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have you had emotional blunting and brain fog? if so, does it eliminate? or just reduce it? id love to be able to just be able to make progress in meditation. dunno why i cant anymore
Yeah dude. Baclofen helped with that. A friend and I were trialing it together and we both experienced big benefits mentally, but I’d go into it expecting nothing. I don’t know how to explain it, it didn’t take anxiety away the way benzos do (where it’s like you just don’t care), it helped with symptoms in the way that felt like it wasn’t a drug. Emotions and stuff just felt more normal. Not completely normal, but much better.
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have you tried NSI-189? Apparently a user here claims it makes him feel normal emotionally. anyways thanks for the heads up, ill check it out
Nah I haven’t. That’d be pretty great though, there are times I return to some degree of emotional normalcy but completely normal sounds like a dream.
I wish I could find something for cognition too. I don’t feel anywhere near as quick as before and my near eidetic memory is gone so that’s pretty shit.
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Hope baclofen works out if you decide to try it, and if so, report your experience here.
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