Accutane recovery, then Finasteride crash

Welcome to our community. Please fill in the following template as a way of introducing yourself, and helping others to understand your background and situation.

Where are you from (country)?


How did you find this forum (Google search – if so, what search terms? Via link from a forum or website – if so, what page? Other?)

Googled "propecia side effects"

What is your current age, height, weight?

24, 6’ 3", 165lbs

What specific drug did you use (finasteride, dutasteride, saw palmetto, isotretinoin/Accutane, fluoxetine, sertraline, citalopram, leuprorelin, etc…)?

Accutane then Finasteride

What dose did you take (eg. 1 mg/day, 1 mg every other day etc.)?


What condition was being treated with the drug?


For how long did you take the drug (weeks/months/years)?

1 day

How old were you, and WHEN (date) did you start the drug?

December 5th, 2019

How old were you when you quit, and WHEN (date) did you quit?

December 5th, 2019

How did you quit (cold turkey or taper off)?


How long into your usage did you notice the onset of side effects?

A few hours after the first pill

What side effects did you experience that have yet to resolve since discontinuation?

Check the boxes that apply. You can save your post first, then interactively check/uncheck the boxes by clicking on them. If your symptoms change, please update your list.

[x] Loss of Libido / Sex Drive
[x] Erectile Dysfunction
[ ] Complete Impotence
[x] Loss of Morning Erections
[x] Loss of Spontaneous Erections
[x] Loss of Nocturnal Erections
[ ] Watery Ejaculate
[ ] Reduced Ejaculate
[ ] Inability or Difficulty to Ejaculate / Orgasm
[ ] Reduced Sperm Count / Motility

[*] Emotional Blunting / Emotionally Flat
[x] Difficulty Focusing / Concentrating
[x] Confusion
[x] Memory Loss / Forgetfulness
[ ] Stumbling over Words / Losing Train of Thought
[ ] Slurring of Speech
[x] Lack of Motivation / Feeling Passive / Complacency
[ ] Extreme Anxiety / Panic Attacks
[x] Severe Depression / Melancholy
[x] Suicidal Thoughts

[x] Penile Tissue Changes (narrowing, shrinkage, wrinkled)
[ ] Penis curvature / rotation on axis
[ ] Testicular Pain (temporary)
[ ] Testicular Shrinkage / Loss of Fullness
[x] Genital numbness / sensitivity decrease
[ ] Weight Gain
[ ] Gynecomastia (male breasts)
[ ] Muscle Wastage
[ ] Muscle Weakness
[ ] Joint Pain
[ ] Dry / Dark Circles under eyes

[ ] Prostate pain
[x] Persistent Fatigue / Exhaustion
[ ] Stomach Pains / Digestion Problems
[ ] Constipation / “Poo Pellets”
[x] Vision - Acuity Decrease / Blurriness
[ ] Tinnitus (ringing or high pitched sound in ears)
[ ] Hearing loss
[ ] Increased hair loss
[ ] Frequent urination
[ ] Lowered body temperature

[ ] Other (please explain)

What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug?

I have been taking maca root powder, cacao powder, vitamin D, Calcium D-Glucarate, Bile Acid and psilocybin mushrooms (1 4 gram trip every 5 days)

If you have pre or post-drug blood tests, what hormonal changes have you encountered since discontinuing the drug (please post your test results in the “Blood Tests” section and link to them in your post)?

Anything not listed in the above questions you’d like to share about your experience?

Tell us your story, in your own words, about your usage and side effects experienced while on/off the drug.

Hi everyone,

This is my first post. So, about 13 months ago I started Accutane, I believed the doctor when she said it would be safe even after hearing the stories, so I underwent this treatment and it was effective at getting rid of my acne however it caused extreme fatigue, depression, loss of libido, loss of mind-penis connection, and emotional blunting. These were gradual effects so I did not think much of it at the time and I was also attributing a lot of it to work stress and assumed the side effects would subside after I got off the drug. Looking back on it, I did have work stress but this caused major changes in personality. Towards the tail end I feel like my work performance suffered and I became someone no one wanted to be around. I had zero energy all the time, and was therefore never ready to help. While before this I was full of energy and ready to help everyone. After realizing this I thought it best to quit this job and take some time to recover my mind and body, I continued my job for three months after quitting Accutane but could barely make it through the day and still felt a disconnect from my emotions and libido. So I decided to quit and focus on recovery. I was eating healthy, exercising, not masturbating, and then taking vitamin D, Calcium D-Glucarate and Bile Acid.

This protocol was doing me great benefit, but I still felt disconnected from my emotions and libido, so I decided to start “psilocybin” therapy. I have prior experience with mushrooms, and I believe they can have a profound healing effect on the body and mind (there are also studies that prove this). So I began taking 4 grams of psilocybin mushrooms every 4-5 days for 2 months. I felt like my brain and body had been completely reset. Each trip I tried to feel my emotions and sexual energy again. It felt like my brain was re-finding these emotions again for the first time. I was having memories of my emotions and sexual experiences going back to my childhood. At the end of these two months, I was feeling great, recovered and unstoppable which leads me to the next chapter.

I liked the idea of keeping my hair, and because I felt 100% healthy again I decided to try another prescription drug for hair loss (huge mistake). If you ever feel healthy DO NOT ever compromise your health with any drug! But the risks seemed small and I thought I could recover if anything went wrong.

I got the drug online, $5 for 30 pills, at least it was cheap. It arrived but was left unopened for about a week as I was aware of some of the side effects and was still debating if it was even worth it. However, I eventually thought since I am feeling so good and I was very in tune with my body, I could test half a pill and see if I notice any effect, so without much thought I cut a pill in half and swallowed it, at night. Soon after I thought this whole idea was kind of stupid, because I am really not planning to take this drug every night for the next ten years and my hair loss is not that bad anyway.

I went to sleep and woke up after a few hours after very poor sleep. I noticed brain fog, like my head was cloudy, dizzy and spinning but didn’t think much of it. I watched some porn and noticed my libido and erections were very strong, stronger than normal. I understand this was from the increase in testosterone. My mental clarity felt off, but everything else seemed to be working normal. The second night came and I decided already not to take another pill although I was feeling relatively fine, so I went to sleep and noticed that I slept for only about 5 hours.

I was a little worried but not so much as I understand the drugs effects are strong and take at least a couple days to start wearing off. So I waited it out, but the symptoms seemed to be staying pretty consistent for about a week. Brain fog, insomnia, increased sexual drive. I decided to watch porn while I waited for this drug to wear off, as I did not feel productive doing much else. I probably shouldn’t have done this, I was masturbating a lot about 3 times a day and by the 7th night I experienced multiple cold chills running through my body, I woke up early morning feeling horrible and then experienced the CRASH, within a few minutes, it seemed as my life force was completely drained. I felt empty of emotions and libido and also started experiencing horrible anxiety and severe depression, I stayed in bed all day and did not eat. I had a horrible sleep filled with nightmares, and my penis was completely dead.

Then when I got up the next day, my boss from the job I quit called me. Some other people recently quit, so they wanted me back and were willing to pay double my salary. In my mind I knew this was great news, but I could not get happy due to my severe lack of emotions, disconnect with reality and generally feeling like shit. However, I called my boss back on Thursday and accepted the offer, hoping to God I could recover in a few days, before starting on Monday. I did not and my condition barely improved. I had zero libido, intense brain fog, severe depression, insomnia, anxiety, fatigue and suicidal ideation. I pushed through it, but ended up leaving early on Wednesday because I was getting no work done. I spent the next week recovering because it was thankfully Christmas break. I went back to my post Accutane protocol of eating healthy, exercising, not masturbating, and taking vitamin D, Calcium D-Glucarate and Bile Acid and mushrooms every 5 days. Things were still horrible when I returned from break on January 2, so I called in sick on Jan 2nd, 3rd, 4th. I just went in today, and was actually able to get a bit of work done, but this was most likely due to having taken 25mg of modafinil this morning. The mental sides do seem to be getting better, but my libido is about 20% and I am still experiencing insomnia (can’t sleep for more than 3-4 hours at a time), no spontaneous erections, weak erections, and my penis also seems to be in a constant cold state (hard flaccid) and lacking sensitivity.

Anyway that is my story thus far and log, my plan is to stay on the protocol I had post-Accutane and hopefully my condition will slowly improve. I do strongly recommend the mushroom protocol as I think it had the most rewarding results (If you are new to mushrooms I would recommend 1 gram every week, then slowly increase dosage as necessary). If you live in the US/Europe you can order the shrooms online and have it shipped to your door. I recommend everyone try this. Since taking propecia on December 5th, I had 4 mushroom trips. The first trip was absolutely horrible but each trip does seem get better and afterwards it does feel like it is kickstarting the healing process.

Fuck this drug.




UPDATE (Day 40):

Brain fog has greatly improved, however depression, anhedonia and no libido still persist.

Still battling insomnia, can only sleep 3-4 hours at a time (valerian root seems to work best so far for sleep issues).

Penis shrinkage/sensitivity seems to be improving, and sensitivity seems to be minimal but better than it was 2 weeks ago.

I keep skipping days of work because when I first get up in the morning depression and anxiety seem to be at its worst, and my sleep is usually so horrible the night before I have the effects of sleep deprivation. I may have to quit my job soon and sell my car to support myself, as I recover. Wish me luck guys, I am praying for all of you out there.


Glad to hear you are improving!!! Any idea what specifically helped the brain fog?


I noticed a most immediate improvement from these three supplements, not taken together necessarily.

  1. Iodine
  2. Maca and cacao powder drink
  3. Phenibut

I also seem to be very clear headed and don’t need much supplements during the day if I can just get high quality sleep the night before and for that I use 5-HTP and Valerian Root at night, which reduce the fog the next day.

Then just avoiding caffeine, as it gives me horrible fog shortly after the initial high. Then also avoiding blood sugar spikes from sugary foods.

Doing all these in conjunction seemed to get the fog under control.

Be careful with 5-htp, I took it for 9 days and it gave me all the symptoms of PFS permanently …

1 Like

@Iso_fin_doubledamage sorry to hear that you’re struggling so much with work. Sleep and fatigue are big problems for me too.

Around 40 days in, I had reduced my working hours considerably. I’m not sure how I would have coped if I’d had to just keep working. Perhaps you should think about doing less, rather than just stopping outright. Could you speak to someone and explain your difficulties, hopefully with the outcome being either more flexible or less working hours?

If you sell your car, what happens when that money has gone?

Thanks Greek,

I already reduced my hours to part time but its still a struggle. Can I get disability if I quit my job due to this syndrome? If not, I was planning to sell my car which would give me about 3 months to live on, then after that I will hopefully be in a healthier state and I could reapply somewhere else. If I still cannot, I can go live off my family for another 3 months, and again hope that after that I will be healthy enough to get another job.

By the way, I live in Northern California, and was wondering if you know if there is a list anywhere on this site of Doctors that specialize with PFS? I also have family in Southern California.


UPDATE (Day 41):

Took NSI-189 and going to continue taking 50mg once a day for help with anhedonia and depression. I have used this before post-Accutane, and it did seem to help with emotional blunting and depression.

Sorry to hear that you’re already on reduced hours and struggling. By around 90 days I was just about able to get through a normal working week again. It’s still hard but sometimes things are almost back to normal for me. I can’t tell what makes for good or bad days yet. I hope you see some improvements soon.

Re: disability, I don’t know if that’s a possibility but hopefully it won’t come to it.

There are some doctors listed on the foundation website - you might like to look up who might be able to help with getting your condition recognised for the purposes of receiving disability payments but I honestly don’t know how that might go when the syndrome isn’t formally recognised. The survey we are launching soon will help with recognition, when the time comes it will be important that everyone fills it out.

I don’t know about specific doctors but I believe there’s a guy in San Diego on the list. I would advise you to be cautious if you’re short on money. I’ve read that at least some of these doctors don’t take medical insurance and that they are expensive. On top of that is the problem that there is no guaranteed effective treatment at this time. Some people here seem to have had success with some treatments.

At least one of the doctors will give a ten minute Skype consultation which could help you find out if you could diagnosed as then eligible for disability payments.

So when you had emotional blunting from accutane, the shrooms alone helped your recover? If yes, how soon were they helping you? It seems as though they are not helping you as much currently when it comes to the emotional blunting from finasteride.

also, have you noticed anything from the NSI-189 yet?

@Northern_Star this guy’s taken NSI-189 and claims it helped him in the past FYI

Hi lakehouse,

Mushrooms seemed to help pull me out of depression that I entered because of Accutane, without it I am unsure I would have snapped out of it by myself and make some improvements to get better. Then with continual use I noticed an accumulation of overall positive effects, well-being. A lot of trips were very emotional, crying etc. I would equate one mushroom trip to months worth of psychotherapy. In general I think mushrooms are greatly beneficial for anyone’s mental health, and especially depression.

As for NSI-189, I have been taking it the past 3 days and noticed a big improvement with my depression, anhedonia and emotional blunting. It was an immediate improvement, I would say about an hour after taking it I felt 100% back to normal mentally, if it wasn’t for the lack of libido. I was surprised. I am definitely going to continue taking this as it seems to make a huge difference in terms of depression and anhedonia, and hopefully the effects will last.

Thanks Greek for this information, I will check this out. Seeing a doctor is a last resort as I know there is no known cure and I am short on money. Because I am only 45 days since quitting, I am still hoping for a natural recovery, things do seem to be improving very slowly. Next week I am going to try to push myself to go back to work at least 15 hours a week, otherwise I feel like I may lose this job. Thanks again for your support.

How is your situation at the moment?

Just a funny side note, I took this before. And it seems like I can not take it for to long or else my emotional responses to situations become more and more childlike. The drug is suppose to grow new neurons in your hippocampus and it really does feel like that starts happening if you continue taking this for weeks. You would think this would be a good thing but let me tell you, it is a very strange experience to have child like emotional responses to situations when you are a fully grown adult, HAHA. My brother also took this drug, and noticed a similar effect.

Oh wow! Didn’t realize you were only ~45 days out from onset. You have a good chance at significant natural recovery, going by past anecdotes of victims of this condition. My 2 cents is to leave it alone and forego treatments in these early days, even if that means forcing youself through work days and general day-to-day activities for a few months. However you decide to handle this, it’s good to hear you are improving.


sorry im confused now, so I will ask these questions.

When you got emotional blunting from accutane, what helped you get your emotions back?

also, do you get insomnia from nsi-189?

@Iso_fin_doubledamage Do you think the mushrooms are what helped your fog? Mine is highly visual and it sucks. Looking for some options that are not totally dangerous

Both psilocybin and nsi-189 helped bring back my emotions. If I keep taking nsi-189 it does begin to give me insomnia after about the third day.

Sorry for the late response.

In terms of percentage how much better are you?

No offense intended when I ask this but the percentage scale isn’t really helpful is it? It’s so perceptual that my 90% might be quite different to yours.

It might be better to ask more direct questions. If I tell you I’m at 80%, what does that mean for libido, sleep, etc?

I think we should leave the percentage scale behind.

Disagree. I want to see progress for a specific symptom in this context - emotional blunting.