Hi Pete, regarding the time dependent impact on ED incidences, the effect of long term deprivation of DHT is not the same as what is observed in PFS. One is an absence of potent ligand which over time can obviously lead to physiological changes, and is often demonstrated with huge doses for prolonged periods in rats. This has been demonstrated to result in incomplete return of erectile function and several other observed physiological changes. However, PFS entails a bodily response to the depletion of ligand or inhibition of the AR which is seemingly a persistent epigenetic change in cellular homeostasis, entailing a altered cellular response to the presence of ligand. The latest literature review notes pfs as occurring in as little as a few doses, whereas we’ve often seen even one pill causing PFS. I think this is the situation for user LBV amongst others.
“Moreover, the finding that DHT increases inducible nitric oxide (NO) synthase (iNOS) from DPC suggests that iNOS and NO are downstream effectors of AR” (Androgens and androgen receptor action in skin and hair follicles, Ceruti et al 2017)