5AR fails to return to baseline levels!I found PFS on pubmed

[xptriado]

@iwillrecover2016

There is money for geneticist to figure out how to produce 5ar. There is a rare genetic disorder of deficiency of 5ar.
Perhaps they can turn on the gene to produce natural 5ar again in the body. This is years away but may be possible because of the advancing tech.
The last thing we want is artificial 5ar. They can already make synthetic enzymes but we should try to get the real thing.

It doesbt seem to be just a problem of 5ari, as much as it is a consequence
Lets wait for Baylor, the AR signaling pathway seems broken

[spstriken]

@xptriado

There was a guy recovering with Rifampicin

Rifampicin (RIF) is a potent inducer of CYP3A4 !!!

I think CYP3A4 is connected to vitamin D!!!

I THINK THIS ENZYME IS DOWNREGULATED IN THE ONES WITH LOW VITAMIN D!

Finasteride uses this enzyme as a substrat but also “Importantly, finasteride itself is metabolized by CYP3A4, suggesting that high-dose finasteride might prevent its own metabolism (27).”
propeciahelp.com/forum/viewt … f=8&t=2703

What a coincidence. I have had the same conclusion that our P450 enzymes are doomed. and they found rifampicin and was seaching and got this thread. Have you tried rifampicin?

[M_C]

Adding fuel to the fire here – I took Goldenseal, which is an inhibitor of CYP3A4, and I felt a lot worse very quickly. Felt like a mini-crash.

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human...

[AaronF]

If I’m correct the Ketonozole shampoo I crashed from also inhibits CYP3A4

[nw0ordeath]

You probably crashed from the SP in the shampoo, tho anything is possible.

[JustTrynaMakeIt]

But how do we do that? Would love some advice esp if you’re feeling better mate!!