Seems like cortisol management is very important, but there are people who got no benefit from supplementing it. Maybe their dosing was off or they didn’t do it for long enough. Another “one size doesn’t fit all” puzzle regarding PFS.
Did anyone buy this publication sciencedirect.com/science/ar … 6014000831?
Keen to share with my endo at next appointment if anyone has it.
I don’t have it, but this is the study they released in 2013. Would be nice if they offered course of action regarding all this mayhem.
No doctor would rightfully do this, because we’d all line up and beg them to try, but after publishing an article on this, it would give us all hope if the authors theorized potential therapies that could help us. If only someone here had access and could pick their brains. So how to right these altered levels?
I believe this was the preliminary Italian study that led to the present study on PFS launched at the University of Milan by the same group of researchers. The Uni of Milan study is trying to explain the root cause of this condition. It is the most promising study to date, although the north american studies, and all other studies for that matter, will play a critical role in solving this puzzle.
Has anyone brough this study to the foundation’s attention? or the Italian or American researchers?
Well, does anyone have their contact?
Here are the contacts listed in the studies:
Baylor College study: Dr.Mohit Khera (mkhera@bcm.edu)
University of Milan: Dr. Guido Cavaletti (roberto.melcangi@unimi.it)
Brigham and Women’s Hospital (Harvard): Dr. Shalender Bhasin (sbhasin@partners.org)
Sadly, we all know that 5ar fails to return to baseline. I hope once these current studies are complete researchers move on to actually figuring out how to increase / repair our enzymes. Unfortunately, there is no money involved for big pharama that’s why no treatments have been discovered
There is money for geneticist to figure out how to produce 5ar. There is a rare genetic disorder of deficiency of 5ar.
Perhaps they can turn on the gene to produce natural 5ar again in the body. This is years away but may be possible because of the advancing tech.
The last thing we want is artificial 5ar. They can already make synthetic enzymes but we should try to get the real thing.
It doesbt seem to be just a problem of 5ari, as much as it is a consequence
Lets wait for Baylor, the AR signaling pathway seems broken
What a coincidence. I have had the same conclusion that our P450 enzymes are doomed. and they found rifampicin and was seaching and got this thread. Have you tried rifampicin?
Adding fuel to the fire here – I took Goldenseal, which is an inhibitor of CYP3A4, and I felt a lot worse very quickly. Felt like a mini-crash.
If I’m correct the Ketonozole shampoo I crashed from also inhibits CYP3A4
You probably crashed from the SP in the shampoo, tho anything is possible.
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But how do we do that? Would love some advice esp if you’re feeling better mate!!
Does it seem that sulforaphane and St. John’s wort can be useful?
For what purpose? Have you searched the forum to find other people’s experiences? St John’s Wort is very well known and freely available.
My first thought would be: unlikely. If it was helpful, we’d all know about it, surely?
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Sulforaphane is found in broccoli and cauliflower. Both plants are hybrids, thus you will never find wild versions, only farmed.
You mentioned creatine elsewhere, but rather than patchy post, I’ll condense here. Creatine is one of the amino acids, building blocks, found in meat. Anyone who eats meat takes it in naturally. I suppose the other amino acids balance it out. Interestingly, raw meat has more creatine than cooked meat, and cooked meat has more creatinine than raw meat. See the 1st paragraph under the “Results and discussion” column: https://pmc.ncbi.nlm.nih.gov/articles/PMC8292545/ I ate raw meat for 10 years, never had a problem with it, but @OZEPH was infected with parasites his first time.
As for st johns wort, I like the taste, especially freshly picked. Pills don’t taste good. I believe in chewing food, not swallowing it whole. We are not snakes; they swallow their food whole. Digestion begins in our mouth, not stomach. If I must use herbal pills of whatever sort for whatever reason, I chew them, and similarly, I open capsules and pour the contents in my mouth, and discard the cellulose/gelatin material. Pills and capsules hit me stronger this way. Chewed meat will digest easier than meat swallowed whole, you see.
Around the 7-9 month mark, I used st johns for a few months, skipping days here and there. Helpful for mood, but sexual function was nonexistent at the time anyway. Some say it gave them PSSD because of its serotonin effects. On occasion, I will use it as a spice in food or drink mix recipes with damiana, no problems. The 2 yellow flowers are so pretty. I want them in my yard, and although damiana grows in my region, it is not native. St johns wort is native to my region, meaning it will be better for the environment and be easier to grow.
St Johns wort:
Damiana:
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