5 ALFA REDUCTASE TYPE 2 SYNTHESIZED

Therapeutic Efforts Pharmaceutical
#1

I read over the internet that Swiss labolatory synthesized 5 alfa reductase type 2 enzyme. Unfortunetely I cannot find this page right now.

If there is anyone who could make a theoritical hypothesis of what could be the possible positive impact of 5AR enzyme injections, if the cause of our problems would be associated with 5 alfa reductase type 2 deficiency.

I know that 5 AR should be present in every cell, and 5AR molecule is different from steroids, neurosteroids. So what would be the possible influance if these synthesized molecules whould be injected into the body.

Would it react the same as natural molecules, what would be its bioavailability. Would it possibly mass around with natural molecules.
Finaly what was the reason for this biosynthesis? Is it the synthesis for the potential 5 AR deficiency treatment…?

And first of all could anyone try to find out internet site of this molecular labolatory.

#2

Don’t you think you should get DHT tested before you come to such conclusions as you do?

I’m sorry but many men on this forum have perfectly normal DHT levels, including myself.

5-alpha reductase is not the problem here, it is only the cause. In my opinion 5-AR and DHT levels come back to normal in nearly all men who use and then quit using finasteride.

#3

Yes. But there is still a number of pepole whose hairloss does not resume despite quiting. I even regrew some hair long after I qiut Dutasteride. THis is the reason I suspect Dutasteride shot down my 5 alfa reductase.

I can’t test it in my country. DO you know of any clinic which do DHT test in Europe???

#4

I took a test in Finland, the sample went to Germany for analysis. It came back at 1.1 (0.6-3.3) months after quitting.

#5

So it definetely looks low. I think it is a good example that Finasteride is messing with 5 AR.

#6

Yes. The only problem is that I did not take blood tests before the treatment (I was not expecting these problems, so why would I) so I have no idea where my levels were before this. Based on my physique, skin, hairloss etc I would guess that my T and DHT were quite high.

#7

You might not do DHT test before. But you can definetely evaluate the level of hairloss/sebum that you were going through before the treatment and compare it to your current situation.

If it decreased significantly then your 5AR/DHT output is lower and that’s the case then…

Onni listen. It is great to have you here. Can you please give me the contact to this German Labolatory/Clinic that was doing your DHT test.
I have the same problem in Poland I have to send my blood sample somewhere to make the evaluation.

I need adres and/or telefon number.

Thanx on advance.

#8

I’m just throwing this out there, but what if the DHT that is in circulation (ie, showing up in test results) is being supplied by 5AR1, not 5AR2 if it were no longer working?

PS Majkellos: It’s “5-Alpha”, not “5-Alfa”. :slight_smile:

#9

Mew you might be right. Onni result looks to be semi-low, so it might be…

That’s why I prefere to focuse on hair condition. I had a very agressive MPB type. Now, loosing hair is something that I am not familiar with. In my case it might be even worse then Onni.

Ok.Alpha of corse, in Polish it’s alfa… I write pretty fast so there are a couple of mistakes every time I guess… cheers.

#10

My face used to be really oily: Only a few hours after a shower my T-zone (nose+forehead) would be all oily. Now I don’t need to clean my face for days and my skin is extremely dry. No zits either…I used to get acno no matter how good care I took of my face…so something has def. changed.

My hair looks ten times worse than before treatment. The texture is extremely dry and thin, and it’s impossible to manage. I really don’t look healthy now.

#11

So we are propably going through similar situation.

I also used to have oily skin. I produced loads of sebum only a few hours after shower.

I also was very skiny with a pure, healthy looking skin on my face.

Now. My skin is also dry. I think it looks a bit yellowish, with some strange redish spots on my nose and jowls. It is also not skiny any more, but fullfilled with water.

One day my hair looks dry and brown, but some other day they look more oily and black. I do not loose them as much as I was before the treatment.

I also gained some body fat. The whole situation remains 3 years.

If this is not due to the 5AR partial cell death, call me a rabit. But do not worry your blood test will show you that you are within range… what a f***n’ disaster.

Onni if you could give the adres to this German clinic/lab I would be greatfull.

#12

Hi. Yes, my face is also not only dry, but looks dull and without the form it used to have (others have noticed this too). It is also a bit yellow/reddish compared to my former nice complexion. People constantly think that I’m hung over or extremely tired - I am not. I have also gained over 15kg in a matter of months and I am all wobbly. This and the gyno is killing me and I am uncomfortable 24/7. Have you noticed anythingk weird with your body temperature or beard growth?

I do not know the name of the lab, I used the finnish firm Diacor (www.diacor.fi) and all their DHT-tests go to germany. How is it not possible to test for DHT in Poland? You could always email Diacor and ask for the name if this lab.

Yes, it seems that we are irreversably fucked. I can’t believe that I have even taken meds like MTX (also used for cancer patients) and have never had sides, and then get burnt so bad by some f’n hairloss pill.

#13

Thanks for this contact to Diacor. I will find out where they are sending these blood samples.

Onni I am almost sure, after such a long time (in my case) that these poisonous pills have partialy killed our cells. Cell death according to my knowledge seems to be irreversable.

I did not measure my body temperature for a very long time. My beard is much softer then it was before and I only shave twice a week…

You are right that there is propably no other drug that has an ability to kill cells responsible for such important things in our body. Even steroids does not provide such ability.

The question is if cells can regenerate…? According to my long term distaster it cannot and it is permanent.

#14

What cells do you mean? Isn’t it possible that your DHT has simply been permanently left on a lower level, hence making you feel like shit? I have been reading about these things for months and have no idea what the hell is going on anymore.

I read that you tried Dostinex too? I’m taking that aswell and am feeling a bit better. I just feel like a jackass having to take drugs for drug side effects

How old are you?

#15

DHT output is directly related to the 5AR activity which is present in cells.

If there is a decreased number of cells, if there were a partial cell death due to the drug abuse, then your DHT output might be limited. This is what I suspect.

Distinex have helped me a bit, but did not multiply my cells with 5AR molecules. That’s why it’s efect was limited I suppose.

My beard is softer, I only have to shave twice a week…

#16

Mine too, I can’t even hear or feel it “crack” when I shave and my T-levels are good shape as are yours. So we seem to be in the same boat.

#17

I realy wonder how is with your progesteron levels. If it is elevated welcome to the club…

From the theoritical backround if progesteron cannot be sufficiently converted to its metabolites (5alpha-nor-progesteron—>allopregnolon) it keeps cumulating because it still expects to be converted…

It you are 5 AR deficient, then the conversion will be limited and progesteron propably will cumulate.

Check this out.

PS: How long did you take finasteride?

#18

I will test my progesteron, I have tested pretty much everything else. What are the symptoms of high progesterone? Isn’t “decadick” caused by this?

I took fin for 4 months with a few sides and the worst came a few weeks after i quit, as if my whole body just crashed.

#19

Elevated progesteron makes “decadick syndrom” — exactly.

I had it due to the progesteron elevation, but it went away when I stopped drinking alcohol and reduced smoking. How do you feel about that?

I took fin for almost 5 years.

#20

Does it also elevate prolactin? As my prolactin was elevated, but E2 was low so I’m guessing something else elevated prolactin. I also understood that dostinex is used to fight progesteron gyno, so does it affect progesteron or only prolactin i.e. will dostinex affect my progesteron result?