Propably the bed news…
Progesteron usually elevate prolactin, so it also elevates cortisol. Progesteron is related to prolactin and mostly cortisol.
Dostinex fight prolactin (should help you), but does not to much to progesteron itself.
Elevated autosomal progesteron seems to be an effect in cell mutations. This is what my endocrynologist said.
Oh dear. My cortisol was elevated aswell. Will have to test this to confirm. If my E2 was in check, the gyno, dick changes and others might have much to do with this. Will keep you posted, I have an endo appointment 8.1
E2 has nothing to do with it. My E2 was brilliant as you might see in the hormon test section.
Elevated progesteron is a 5 AR deficiency symptom because, as I prevously said, It elevates while cannot be further converted via 5AR.
But propably we would not sentence Merck for this, because non of the endocrynologists focus on this phenomenon, and the role of progesteron in male subject is under estimated and not well understood.
The problem starts when it comes to the 5AR cellular death, but for doctors it’s sience fiction, propably more understandable for sientists who will not help us.
But it definetely shows what actually we are dealing with. Decadick is a direct feedback of this imbalance.
Nevertheless, Merck will take your DHT test and will argue in a court that it’s ok… that you are perfectly ok, within range, and they have no idea why progesteron is high or beyond range…
Muth****ers are well prepared to sell this shit on the market. You won’t bite them.
I think it would be quite easy to get Merck in trouble as undocumented sides such as extreme depression and anxiety are not documented sides and can be medically proven, and could lead to horrible consequences and the drug in fact does so much more than just halt hair loss.
Have you had any improvement in your case? If I’m going to be like this for many years, the future is not looking very bright
I have no answer for us.
I have this problem for 3 years. Due to this very long period of time, I am affraid this is permanent and is associated with cell death/mutation.
If my body self recovery program did not work, then it seems that I propably have insufficient number of tools to activate this self-recovery process…
I can imagine that pushing cells in a constant manner can result in a permanent cellular distruction/mutation, but I have no idea how anybody could produce/sell a drug that has, even a minor ability to do so… especialy when it comes to a silly hair treatment.
What is this “decadick” you guys are talking about?
I for one did have elevated progesterone, and yes eliminating drug or alcohol intake helps with that.
I also had a little bit of higher prolactin…
I will have to get new blood tests done to show where I am right now.
Welcome to the club… have you even tried to logicaly figure out why your progesteron is elevated hah?
Majkellos,
What is this? I looked it up and it does not exist. Suggest you take a look at page 3 for a diagram of the conversions inhibited by Finasteride:
blackwell-synergy.com/doi/pd … 06.00053.x
I understand you are concerned about elevated Progesterone being an issue, I have read that it can operate as a 5AR inhibitor itself. But of course, Progesterone is also a valuable hormone that catalyzes the 5AR reduction to the neurosteroid Allopregnanolone, which is very important.
If you are concerned about your elevated Progesterone levels, have you discussed this with your doctors? What have they said about it?
I would highly recommend backing your points up with scientific studies… otherwise this is all just speculation in the eys of the medical community. No offense, but it’s important you are able to prove your claims if you plan on trying to get treatment.
Also, have a read through this – Dut inhibits Progesterone 5AR reduction as well (no surprises there): sciencedirect.com/science?_o … a0875f1d4b
Yes there is a 5-alpha dihydroprogesterone insted of 5 alpha nor progesteron. Yes you are right about that.
Hey I just remembered, dutasteride has a much, much, much longer half-life than finasteride does, and persistent side effects of dutasteride are actually legitimately recognized within the medical community (unlike finasteride).
So you very well might be having problems getting the drug’s effects out of your system and getting your DHT back up. Once again though, blood tests would be very important for something like this.
I don’t know if this is possible, but you might want to try looking for ways to detox yourself or get dutasteride out of your system. Normally dutasteride takes over a year to be metabolized by the liver (no joke) while finasteride only takes like 2 days or something.
I would think it would be beneficial for you if you could get tested on how much dutasteride is still in your blood, but I don’t even know if such tests exist.
If low DHT is in fact the case with you, you might want to ask your doctor for a prescription to proviron.
Proviron is synthetic DHT and continued use would likely shutdown the HTPA via negative feedback, resulting in low T… exactly the situation nobody wants. But do your research…
Mew. I forgot to ask you. Do you still suffer hairloss or it does not resume any more or is slowed down? How about you sebacious gland supply?
Listen Mew. I was popping Dutasteride once a week providing 0,5 mg capsule.
One 0,5 mg of Dut only inhibits just as much DHT as Finasteride. One 0,5 mg gelatine capsule does almost nothing to 5AR type I, because the volume of DHT inhibition is being build over time. One single capsule has no ability to radicaly inhibit type I of 5AR.
After 2 months with this dutasteride treatment system, I woke up one day with a total lack of energy/libido/ etc.
This is propably the reason why our experience despite the fact I used dutasteride instead of Fin, are much more similar then you might actually expect.
I have a total practicaly 100% compatibiltity with Onni sides who used finasteride for the short period of time.
I was providing Proviron treatment and as in many other cases it made all my sides much worse. I also used Clomiphen, Unidest (testosteron)… it all got my situation much worse.
I wonder how it is possible especialy with a potent DHT analog Proviron. Have you got any idea why is that?
Hairloss slowed down for approximately 8 months after quitting the drug but picked up slowly from that point on. Between 14-18 months off it picked up the pace considerably.
I am now losing my hair at a fast rate, however sebaceous gland activity remains low. I rarely get pimples anymore. I also used to have an overactive, itchy scalp (heavy dandruff/seborrheic dermatitis).
Since Finasteride, I have no more sebum buildup and my scalp is never itchy anymore. In other words, similar to the results guys get with Accutane, it seems skin 5AR/sebaceous gland activity has been decreased… not surprising to me.
Refresh my previous post please…
If your sebacious glands and hairloss slowed down we are on the same boat then, together with Onni.
Last time I had a full sebum/hairloss output when I was sick to have sex… with blowing my pents instrument between my legs… It was 3 years ago… Things have changed then…
Our androgen expression is somehow limited. I bet it has something to do with a low 5AR activity, as in my theory.
The oily face-thing is weird. As said, my face used to be very oily and I had to wash my hair every day due to oil. Acne (especially in the back) was an issue too. Now I never get pimples and my body and scalp is extremely dry…so something has definitely changed. The face thing was the first thing I noticed after starting fin…which took under a month to happen. Don’t know if it is due to crashed T or DHT levels…or both.
Can anything be done to seborrheic dermatitis? My derm gave me a mild antibiotic and a cortisol lotion, but they don’t seem to help
DUT is a potent inhibitor of 5AR both types I and II. It inhibits up to 95%-98% of Type II, not sure how much it inhibits Type I (which is present in the brain) but it is significant. One capsule of DUT is much more powerful than Finasteride.
DUT also has a MUCH longer halflife than Fin. Fin halflife is 6-8 hours, DHT returns to baseline approximately 7-14 days later, but can take up to ~ 30 days due to slow-offrate of 5AR enzyme regeneration. DUT haflife is something like 4 MONTHS.
Like I said before, Proviron is synthetic DHT, a steroid, and would likely shutdown the HTPA via negative feedback, thus decreaseing Testosterone. Unless you were using TRT at the same time, you would likely have issues due to HTPA surpression of endogeneous Testosterone.
Were you self-treating or did you follow a protocol under the care of an endocrinologist/doctor? If self treating, bad idea. If under a medical professional, perhaps the dosages/timing were incorrect or treatment not sustained long enough. Or perhaps the form of testosterone you used wasn’t good for you (gel vs shots).
Are you sure that one single Capsule of Dutasteride 0,5 mg is more potent then Finasteride 1mg??
I thought that DHT suppresion is built in time with Dutasteride.
Even Glaxo claim that Dutasteride both DHT supression/half life increases due to the treatment period.
Hormonal therapy was provided directly under endocrinologist control.
Yes, of course. I think you need to do some more research…
Both Finasteride and Dutasteride build up to a steady state in terms of their levels in the bloodstream over many days/weeks with continued use, but DHT surpression begins immediately.
Without specific details of your protocol (dosages, type of medicine (gel, injectable etc), timing of use (every day, every week etc), etc) nobody will be able to provide any quality feedback, only speculation.
Anyway, if you are concerned about defective 5AR, my advice to you is get your 5AR metabolites AND these hormone ratios checked, as noted here:
propeciahelp.com/forum/viewtopic.php?t=761
propeciahelp.com/forum/viewtopic.php?t=1079 (4th post down, including screenshot)
Here’s the deal: You can BELIEVE what you want, but without actual conclusive testing and proof, it is all speculation… unfortunately. I myself will be requesting the above tests next time I see a doctor, and bringing those materials to assist me in proving it IS possible to test 5AR activity.
Good luck.
I wonder if you will succed in geting 5AR genes test.
I heard from my endocrinologist that it costs houndred of thousand dollars.
Mew, would it be also possible for you to search for the potenial medical studies according the problems with regaining DHT after Dutasteride treatment. If there already is a medical backround (as you claim) for such phenomenon, have they actually found the reason how it might possibly happen. Do they know the mechanism??
All that I know is that the medical community consider Dutasteride as a very safe drug… kind of funny… don’t you think?
I am concerned about my DHT situation especially due to misteriously elevated progesteron. it is 50% above the range and there is a high propabilty that it cannot be converted further. That’s why it gets accumulated.
If you consider other options than that, please do inform me.
I am a bit shocked that a single dutasteride capsule is much more potent the Finasteride. On the other hand would it make a difference if most of us suffer almost similar long term side effects…
I also wonder how much time have passed by since you stopped popping Fin…? I stopped with Dut almost 3 years ago, and I don’t think it is still present in my body biochemistry…
Have you got any contact to Dr. Crisler (tests for 5AR activity) or can you help me to find one?